DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir31a and Grik4

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	699	Identity:	156/699 - (22%)
Similarity:	264/699 - (37%)	Gaps:	158/699 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLLISMFILILAAGEGEIIPSMEESVVTNF------VKSLVKTKQAIVFSCLFKD----FKEISL 56
            |..:|..||:.||..| ::.:....:.||.      :.|||..:..|:...:|..    |:|.|
Mouse   220 NASMSHTILLKAAELG-MVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFS- 282

  Fly    57 ALMRINQFVSVVNLNQSYSLTSILTRENYARTSVMVNARCSGSSELLFEASENRYFNKTYQWFLW 121
                       .:||||:       :||.........|.   ||.|||:|             ::
Mouse   283 -----------QSLNQSW-------QENCDHVPFTGPAL---SSALLFDA-------------VY 313

  Fly   122 GVDLEVQSL--------FPLNLNYVGPNAQITYVNETADGY----------AYWDIHSKGRHLKS 168
            .|...||.|        .||:..    :|||.....:...|          .:.:.:|||:  :|
Mouse   314 AVVTAVQELNRSQEIGVKPLSCG----SAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ--RS 372

  Fly   169 NLEINLIATLINDTLNIARDIFHLQSIDFRGQFN---GLTLRG---ASVIDKEDIISNEQIESIL 227
            |..:.:        |...|:.|  |.|   ||::   ||::..   ||.|......:...:.:||
Mouse   373 NYALKI--------LQFTRNGF--QQI---GQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTIL 424

  Fly   228 SRPTKDAGVAAFIK-YHYELLG----------LLRE-----RFNFTVNFRNSRGWAGRLGNTTFR 276
            ..|      ...:| .|.|:.|          :|:|     |||:.:.......:.....|.|:
Mouse   425 ENP------YLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTW- 482

  Fly   277 LGLLGIVMRNEADIAASGAFNRINRFAEFDTIHQSWKFETAFLYRYTSDLDTHGKSG--NFLSPF 339
            .|::|.::..:||:|.:|......|....|..........:.|||    :....:.|  :||.||
Mouse   483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR----VHMGRRPGYFSFLDPF 543

  Fly   340 SDRVWLFCLLTLGAFSIIWVLFEIIDYKILRIRVNSQKLEHLNQKSSVICIKTTCIERILQ---- 400
            |..||||.||...|.|.  |||.:            .:|......|...|.:..|...:.|
Mouse   544 SPGVWLFMLLAYLAVSC--VLFLV------------ARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   401 -----TFGACCQQGLDPNPVDRSVRFLVMTLFLFSLVMYNYYTSSVVGGLLSSSDQGP-STVDEI 459
                 ..|...|||....|...|.|.:....:.|:|::.:.||:::...|.....:.| .:||::
Mouse   595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDL 659

  Fly   460 TASPLKISFEDI--GYYKVLFRESQNRSITRLIEKKLSSSRSLNELPIFSHIEDAVPYLKAGGFA 522
             |....|.:..|  |.....|:.|:.::..|:.....|...|:    .....|:.:..:....:|
Mouse   660 -ADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSV----FVKSTEEGIARVLNSNYA 719

  Fly   523 FHCEVVDAYPVISEYFDANEICDLREVSGLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVER 587
            |..|     ..::||:.... |:|.::.||::.:.....:...|.:.:.|..|:...||...:|
Mouse   720 FLLE-----STMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLE- 777

  Fly   588 ILRRRQIKKPAC--QSLYTVYPVSLSGVLPGFVILICGFGASLLLLCLE 634
            ||:|:..:...|  :..:....:.:..:...||:||||...::.:..||
Mouse   778 ILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	49/227 (22%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	54/236 (23%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	90/406 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910