DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir31a and grin2b

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_017948700.2	Gene:	grin2b / 100490580	XenbaseID:	XB-GENE-949327	Length:	1449	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	95/519 - (18%)
Similarity:	170/519 - (32%)	Gaps:	191/519 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLISMFILILAAGEGEIIPSMEESVVTNFVKSLVKTKQAIVFSCLFK--DFKEISLALMRINQFV 65
            |.||:.||.......:..|:|:.:|:      ||.|...:....:.:  ||..:.     :...|
Frog    10 LKISLIILFYMGCYAQKHPNMDIAVI------LVGTTDEVAIKDVHEKDDFHHLP-----VTPRV 63

  Fly    66 SVVNLNQSYSLTSILTR---------------------ENYARTSVMVNARC--------SGSSE 101
            ::|.:|:| ...||:||                     |..|:....::.:.        .|||.
Frog    64 ALVTMNES-DPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSM 127

  Fly   102 LLFEASENRYFNKTYQWFLWGVDLEVQSLFPLNLNYVGPNAQITYVNETADGY----------AY 156
            ::.:..|...|      |.:|..:|.|:...||            :.|..|.|          .|
Frog   128 IMADKEEASMF------FQFGPSIEQQASVMLN------------IMEEYDWYIFSIVTTYFPGY 174

  Fly   157 WDIHSKGRHLKSNLEINLIATLINDTLNIARDIFHL-QSIDFRGQFNGLTLRGASVIDKEDIISN 220
            .|..:|   ::|.:|.:.:...:       .::.|| .|:|                |.:..|.|
Frog   175 QDFENK---VRSTIENSFVGWEL-------EEVIHLDMSLD----------------DNDSKIQN 213

  Fly   221 E----QIESILSRPTKDAGVAAF-IKYHYELLGLLRERFNFTVNFRNSRGW------AGRLGN-- 272
            :    |...||...||:.....| :.:...|.|     :.:|        |      ||....
Frog   214 QLKKLQSPVILLYCTKEEATYIFEVAHSVGLTG-----YGYT--------WIVPSLVAGDTDTVP 265

  Fly   273 TTFRLGLLGIVMRNEAD---------------IAASGAFNRINRFAEFDT----IHQSWKFETAF 318
            ..|..||:. |..:|.|               .|||...:..|...:..:    |.:|..:|...
Frog   266 AEFPTGLIS-VSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCYNIQESRVYEAHM 329

  Fly   319 LYRYTSDLDTHGKSGNF------------------------LSPFSDRVWLFCLLTLGAFSIIWV 359
            |.||..::...|::.:|                        :..:.||       :|.....:|.
Frog   330 LKRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDR-------SLKMKYYVWP 387

  Fly   360 LFEIIDYKILRIRVNSQKLEHLNQKSSVICIKT---TCIERILQTFGACCQQGLDPNPVDRSVR 420
            :||:..        ||:  ||.::..|::.::.   ..:|.:....|.|.:..:   |..:.:|
Frog   388 VFELYP--------NSE--EHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTV---PCRKQIR 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	4/20 (20%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	77/431 (18%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	6/42 (14%)
		NMDAR2_C	837..1449	CDD:402274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910