Protein Alignment CG43672 and ABCA1

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_850354.2
• Gene: ABCA1 / 818768
• AraportID: AT2G41700
• Length: 1882
• Species: Arabidopsis thaliana
• Alignment Length: 2040
• Identity: 414/2040 - (20%)
• Similarity: 731/2040 - (35%)
• Gaps: 545/2040 - (26%)

  Fly     9 FCLLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAE-LLEFSWSSLI 72
            |..::.||:..:..:..|....::||.:..|.|:.:|:..|:.:.......:.: ::|      :
plant     8 FKAMLRKNWLLKTRHPFVTSAEILLPTIVMLLLIAVRTRVDTTIHPAHSNIDKDTVVE------V 66

  Fly    73 GKIQE----RRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVD--F 131
            ||...    ...|:...:.:|          :||||:::..  ..|.|.| .|...|.::|.  |
plant    67 GKGNSPSFPEVLKLLLAEGDF----------LAFAPDTDET--NNMIDIL-SLKFPELRLVTKIF 118

  Fly   132 ENCNDMRIHAASEHYLASVC--FRNV-DESLNGL-------PTVLNFAIIMPSELRNYEDTWIGD 186
            ::..::..:..|.||  .||  .||. :..:.|.       |.:.:::|       ....||...
plant   119 KDDIELETYITSAHY--GVCSEVRNCSNPKIKGAVVFHEQGPHLFDYSI-------RLNHTWAFA 174

  Fly   187 SWKETTTLMDRDVAEEDEFDEDGYT----DYMGEGFVPLQYHISMQFLRATASKVEKLPKVVMR- 246
            .:....::||.:....::.:....|    .|...||:.||..:. .|:...:.:...||.....
plant   175 GFPNVKSIMDTNGPYINDLEMGINTIPTMQYSFSGFLTLQQVVD-SFIIFASQQNNDLPLSHSNL 238

  Fly   247 ----RFNENPNVLLS-------------------EGIGTSVV-LLILLGFMFPVTILTTLIVEER 287
                || |.|..|.|                   :.|..||: ||.||||:||::.|.:..|.|:
plant   239 SSALRF-ELPWTLFSPSVIRMVPFPTREYTDDEFQSIVKSVMGLLYLLGFLFPISRLISYSVFEK 302

  Fly   288 ELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLK---IEWNGATAAVNKCPWPILLC 349
            |...|..|.::.....:...:||......|.:.|.:||....   .:::..|         ::..
plant   303 EQKIREGLYMMGLKDEIFHLSWFITYALQFALCSGIITACTMGSLFKYSDKT---------LVFT 358

  Fly   350 FLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFATVLLCN 414
            :...:|.|...|..::::...|::.|:.:..:.::....|..:..:   :...:.......||..
plant   359 YFFLFGLSAIMLSFMISTFFTRAKTAVAVGTLTFLGAFFPYYTVND---ESVSMVLKVVASLLSP 420

  Fly   415 VSFSRGLSKIFYIEDYTLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFW 479
            .:|:.|.......|...:|:     .:..:.::..|:          :.|..||.|:.::..|..
plant   421 TAFALGSINFADYERAHVGL-----RWSNIWRASSGV----------SFFVCLLMMLLDSILYCA 470

  Fly   480 LAIRVKNLLKKYHATR--------SAVGR----LKRQIP-----------EVS--------FSKT 513
            |.:.:..:|.:.:..|        ...||    |:.:||           ||:        |...
plant   471 LGLYLDKVLPRENGVRYPWNFIFSKYFGRKKNNLQNRIPGFETDMFPADIEVNQGEPFDPVFESI 535

  Fly   514 SAE--------ALIEFRGVWQKYSN---STYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYG 567
            |.|        ..|:.|.:.:.|::   :...|..:.|.:|..::::|||||.:||||.|.||.|
plant   536 SLEMRQQELDGRCIQVRNLHKVYASRRGNCCAVNSLQLTLYENQILSLLGHNGAGKSTTISMLVG 600

  Fly   568 RTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAK 632
            ...|..|:..:.|.:|:|...|..|...:...:..||.||.|.:||...:.|:|:.:...|....
plant   601 LLPPTSGDALILGNSIITNMDEIRKELGVCPQHDILFPELTVREHLEMFAVLKGVEEGSLKSTVV 665

  Fly   633 ALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQK 697
            .:...:.|.|...|||..|:.|.:|.|....|..|.::::|||:|..|:|.....|.:.||...|
plant   666 DMAEEVGLSDKINTLVRALSGGMKRKLSLGIALIGNSKVIILDEPTSGMDPYSMRLTWQLIKKIK 730

  Fly   698 KNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLII-------------- 748
            |.|.|..|:::...|..:.|||.:::.|.|:..|:...|.......|.|.:
plant   731 KGRIILLTTHSMDEAEELGDRIGIMANGSLKCCGSSIFLKHHYGVGYTLTLVKTSPTVSVAAHIV 795

  Fly   749 ------------FGNEKCSFKDVYAFMATF---IPEIEMDSILADCASFLVKHKYHTELINLIEN 798
                        .||| .|||...|.:..|   ..|||      .|    :|:......|:.||:
plant   796 HRHIPSATCVSEVGNE-ISFKLPLASLPCFENMFREIE------SC----MKNSVDRSKISEIED 849

  Fly   799 LARLKND--------LNVYSFE-----IHECSID------DILASLYTR---------DKSTLEF 835
                 :|        ::|.:.|     :..|::|      ||..|..|:         .||::
plant   850 -----SDYPGIQSYGISVTTLEEVFLRVAGCNLDIEDKQEDIFVSPDTKSSLVCIGSNQKSSM-- 907

  Fly   836 GQPGL----------------------------------------------------QTLLASRQ 848
             ||.|                                                    :.|...|.
plant   908 -QPKLLASCNDGAGVIITSVAKAFRLIVAAVWTLIGFISIQCCGCSIISRSMFWRHCKALFIKRA 971

  Fly   849 QSAKR-------RFIIPTMYLLEEL---------RQLLIADTRNWFLPILKLTLPSLVVVWTLSM 897
            :||.|       :||||.::||..|         .|..|..|..:|.|:|........:.:.||:
plant   972 RSACRDRKTVAFQFIIPAVFLLFGLLFLQLKPHPDQKSITLTTAYFNPLLSGKGGGGPIPFDLSV 1036

  Fly   898 P-------YFWHNCRQPGHIT---FP-----MSDHGDGIILMQKDTLDSELLVASEMYAKVGVTE 947
            |       |......||...|   ||     ::|..|.    ...||...||..||..
plant  1037 PIAKEVAQYIEGGWIQPLRNTSYKFPNPKEALADAIDA----AGPTLGPTLLSMSEFL------- 1090

  Fly   948 VDKTVDITTFIYNYEYK-NSLLSDADIMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAF 1011
                  :::|..:|:.: .|:|.|....:    .::...||.|....|..|..: ..:::..:..
plant  1091 ------MSSFDQSYQSRYGSILMDGQHPD----GSLGYTVLHNGTCQHAGPIYI-NVMHAAILRL 1144

  Fly  1012 IDGDAGIKVEL--EVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFI---WSIPLLHMTLSRDG 1071
            ..|:..:.::.  ..||.:....:|.| ::|.:..  |..::..|.||   :::|::.   .|:.
plant  1145 ATGNKNMTIQTRNHPLPPTKTQRIQRH-DLDAFSA--AIIVNIAFSFIPASFAVPIVK---EREV 1203

  Fly  1072 RYNYVELIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAA 1136
            :..:.:||:|:..:...::..:::.:..   |||...|:|.|:
plant  1204 KAKHQQLISGVSVLSYWLSTYVWDFISF---LFPSTFAIILFY---------------------- 1243

  Fly  1137 CVFSLNILITIMPISDMPFVYLKVLLAYSLGI------LVYIAVKELRPFTNPNTAHFLLLDFHP 1195
             .|.|...|.|...  :|.|.:  ||.|.|.|      |.:.       ||..:.|..::|..|.
plant  1244 -AFGLEQFIGIGRF--LPTVLM--LLEYGLAIASSTYCLTFF-------FTEHSMAQNVILMVHF 1296

  Fly  1196 FYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLL-- 1258
            |..|:  ||.|:.:...|...:....|..:.:    ...|..|..|.        |..:.||.
plant  1297 FSGLI--LMVISFVMGLIPATASANSYLKNFF----RLSPGFCFSDG--------LASLALLRQG 1347

  Fly  1259 --------VVVW------------ISIFIFLKSHMVKRRPRQPKY------FWDSDPDSKYDQNI 1297
                    |..|            .|||.||.:..::..|.|...      :|         ||:
plant  1348 MKDKSSHGVFEWNVTGASICYLGLESIFYFLVTLGLELMPVQKVMSFSIGEWW---------QNL 1403

  Fly  1298 LHIME---PSELENTWIHEKSRVST---------LERNHI-----ESKALHVEHLSVFF------ 1339
            ....:   .|..|.........:||         .||:.:     ::..|::::|...:
plant  1404 KAFKQGAGSSSTEPLLKDSTGAISTDMEDDIDVQEERDRVISGLSDNTMLYLQNLRKVYPGDKHH 1468

  Fly  1340 GLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSG-RIISSKTVPFKSKDLDSCH 1403
            |.|.|::.:.|.|...:.....|.||.||:..|..:.|..||:|| ..|..|.:....|.:.. |
plant  1469 GPKVAVQSLTFSVQAGECFGFLGTNGAGKTTTLSMLSGEETPTSGTAFIFGKDIVASPKAIRQ-H 1532

  Fly  1404 MVGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLK 1468
             :||..|.....:.:|:.|..:|..||:...........|:....|.|.|:........|.|..:
plant  1533 -IGYCPQFDALFEYLTVKEHLELYARIKGVVDHRIDNVVTEKLVEFDLLKHSHKPSFTLSGGNKR 1596

  Fly  1469 RLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDL-RRRGHSIIYTCSDTAYSTPAL--RM 1530
            :||:.||::.|..:::||:|.|.:|.|::|.|..:|..| .|.|.:.:...:.:.....||  |:
plant  1597 KLSVAIAMIGDPPIVILDEPSTGMDPVAKRFMWDVISRLSTRSGKTAVILTTHSMNEAQALCTRI 1661

  Fly  1531 ATLSYPGIAVIGEREEMQQNYYSSYYM---------------------------VETRIHLAEL- 1567
            ..:....:..||..:.::..|.:...:                           .:.|..|.:|
plant  1662 GIMVGGRLRCIGSPQHLKTRYGNHLELEVKPNEVSNVELENFCQIIQQWLFNVPTQPRSLLGDLE 1726

  Fly  1568 ---------------GSPIDFDSQSTE------AKEDRAGTTGTLLRHKHQEFSAAFTDS----- 1606
                           .|.|....:..:      ..|.|..|....|..:...|....::.
plant  1727 VCIGVSDSITPDTASASEISLSPEMVQRIAKFLGNEQRVSTLVPPLPEEDVRFDDQLSEQLFRDG 1791

  Fly  1607 -------ADRW----KYLKLCGVIENVFPHAIIKNVSFPRVCFWLS-SHMYPMSR----IVDTL- 1654
                   |:.|    |:..|...|::.||.|..|:      |..|| .:..|...    :.|..
plant  1792 GIPLPIFAEWWLTKEKFSALDSFIQSSFPGATFKS------CNGLSIKYQLPFGEGGLSLADAFG 1850

  Fly  1655 ----HRNKQDFYSFSVSQPSVNSVF 1675
                :||:.....:|:||.::.::|
plant  1851 HLERNRNRLGIAEYSISQSTLETIF 1875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	119/510 (23%)
		ABC_subfamily_A	519..737	CDD:213230	68/220 (31%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	53/194 (27%)
ABCA1	NP_850354.2	rim_protein	<204..1684	CDD:130324	343/1617 (21%)