DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and Abca12

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_780419.2	Gene:	Abca12 / 74591	MGIID:	2676312	Length:	2595	Species:	Mus musculus

Alignment Length:	1791	Identity:	372/1791 - (20%)
Similarity:	662/1791 - (36%)	Gaps:	377/1791 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 DKIVDFENCNDMRIHA----ASEHYLASVCF---------RNVDESLNGLPTVLNFAIIMPSELR 177
            |:|...:...:|...|    .|.....||.|         |..|.....||.::.:.|.|..:.
Mouse   925 DRIQASDTVEEMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKVSLPPIVRYTIRMSLKT- 988

  Fly   178 NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTDYMGEGFVPLQYHISMQFL--------RATA 234
                       .:||..:...:......:...:....|..|:.||..|....:        :..|
Mouse   989 -----------AQTTRSIRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEVA 1042

  Fly   235 SKVEKLPKVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILN 299
            .:|:.:|.....:    .|.|.|  :..|:.:::::.::..:......:|.|::|.....:|::.
Mouse  1043 VQVQAVPYPCFMK----DNFLTS--VSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMG 1101

  Fly   300 ASATLQMAAWFFNVFTHFLITSLLITILLKI-----EWNGATAAVNKCPWPILLCFLISYGCSVT 359
            .::.....||........|:|..::.::||.     :.||.          ||..:...|..||.
Mouse  1102 VNSCSHFFAWLIESIGFLLVTIAILIVILKFGNILPKTNGF----------ILFLYFSDYSFSVI 1156

  Fly   360 SLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDGPDVFYGFATVLLCNVSFSRGL 421
            ::..|::.....:.:|.::..:|:::...|   |::.::.||....||..    ||...:||...
Mouse  1157 AMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIKVFMS----LLSPTAFSYAS 1217

  Fly   422 SKIFYIEDYTLGVTIGKYMFYRVSKSD---FGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLAIR 483
            ..|...|:..:|:. .:.|:....:.|   ||           .:.|.:||..|   .||::|..
Mouse  1218 QYIARYEEQGVGLQ-WENMYKSPVQDDTTSFG-----------WLCCLILADSF---IYFFIAWY 1267

  Fly   484 VKN---------------LLKKYHATRSAVGRLKR-------------QIPEVSFSKTSAEAL-- 518
            |:|               :|..|...|.....:|.             |....|.||||.:..
Mouse  1268 VRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIMMQNTNPSASKTSPDCAFP 1332

  Fly   519 -------------IEFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTR 570
                         :...||.:.|.:.| .|:::.||.|.|.:.:|||.|.:||:|.|.||.|...
Mouse  1333 SNIEPEPKDLQVGVALHGVTKIYGSKT-AVENLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFG 1396

  Fly   571 PKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLR--GLSKTEAKLEAKA 633
            ...|.|::.|.:|.|......||..:.|.:..||:.|...:||:....::  ..:||:...|.|.
Mouse  1397 ATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKR 1461

  Fly   634 LLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKK 698
            .|:...|.......|..|:.|.:|.|....|..||:::||||:|..|:|.......:.:|...|.
Mouse  1462 TLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKT 1526

  Fly   699 NRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF--------GNEKCS 755
            .|:|..::::...|..::|||..|.:|.|:..|:...|.....:.|.|.:.        .|..|.
Mouse  1527 ARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICD 1591

  Fly   756 FKDVYAFMATFIPEIEMDSILADCASFLV------KHKYHTELINLIENLARLKNDLNVYSFEIH 814
            ...|.|.:.:.:||..:..   |....||      ..|.....::|:..|.:....||:..:.|.
Mouse  1592 TVAVTAMIQSHLPEAYLKE---DIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGIS 1653

  Fly   815 ECSIDDILASLYTRDKS-----TLE------FGQP---GLQT---LLASRQQSAKRRFIIPTM-- 860
            :.:::::..:| |:|..     :||      .|.|   |..|   |..|......|...:.|.
Mouse  1654 DTTVEEVFLNL-TKDSQKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSE 1717

  Fly   861 ------YLLEELRQLLIA----DTRNWFLPILKLTLPSLVVVWTLSM----------------PY 899
                  .||:::..:||.    ..|||...|.::.||.:.|...:.:                |.
Mouse  1718 KLEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATAMGLGTLRDSSNSYPEIMISPS 1782

  Fly   900 FWHNCRQPG-HITFPMSDHG-----------DGIIL-------MQKDTLDSELLVASEMYAKVGV 945
            .:....|.. :..|..|..|           |.:.|       ::||.| .:...:.|.....||
Mouse  1783 IYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVCLNTSDLQCLKKDDL-GKWNTSGEAIDNFGV 1846

  Fly   946 TEVDKTVD---------------ITTFIYNYEYK---NSLLSDA-------------------DI 973
            ......|.               .:..|||...|   |.|::.|                   |:
Mouse  1847 CSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLITTANHFVQKRYGGWSFGMKLTNDL 1911

  Fly   974 ---MEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNS--LAVAFIDGDA-------------GIKV 1020
               :.||..:....:|.::.:..|:.|..| .:||:  |.|...:.||             |::.
Mouse  1912 RFDVTAVPDNRTLAKVWYDPEGYHSLPAYL-NSLNNFLLRVNMSEYDAARHGIIMYSHPYPGVQD 1975

  Fly  1021 ELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTI 1085
            :.:....|.|..|.....:.||.:..||       |:..|...|.|.::.     ::.|:|:...
Mouse  1976 QEQATISSLIDILVALSILMGYSVTTAS-------FVTYIVREHQTKAKQ-----LQHISGIGVT 2028

  Fly  1086 VLIVAFLIYELLVVLLAL-FPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMP 1149
            ...|...||:::..|:.: |.|.:..||........:|:...|:.::....|....:.:|..:..
Mouse  2029 CYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLFH 2093

  Fly  1150 ISDMPFV-YLKVLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPFYALLHNLMRIASISEKI 1213
            .:.|.|: |:.|.|.:.:..:|.::|........||.....|:.        ..|.||..|..:
Mouse  2094 ETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELIS--------ETLKRIFLIFPQ- 2149

  Fly  1214 WLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLV---VVWISIFIFLKSHMVK 1275
             .|....:.|.|......:.:.....:...|.:.:..|..:::.||   .::..:.:.:...::|
Mouse  2150 -FCFGYGLIELSQQQAVLDFLKAYGVEYPSETFEMDKLGAMFVALVSQGTMFFLLRLLINEWLIK 2213

  Fly  1276 RRPRQPKYF---WDSDPDSKYDQNILHIMEPSELENTWIHEKSRVST------LERNHIESKALH 1331
            :.    :.|   :.|.|          |||..:.:.....|:.||.:      |.:.|..:|...
Mouse  2214 KL----RLFFRKFTSSP----------IMETVDEDEDVRAERFRVESGAAEFDLVQLHRLTKTYQ 2264

  Fly  1332 VEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRI-ISSKTVPFK 1395
            :.|..:.     |:.:|...:...:...:.|.||.||:.:.|.:.|...||||.| |.:|:....
Mouse  2265 LIHKKII-----AVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSGSLG 2324

  Fly  1396 SKDLDSCHMVGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLS 1460
            ..|..| .:|||..||.....|:|:.|......|:....:...:....||.:...|..|:..|.|
Mouse  2325 HVDSHS-SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKDTVHKLLRRLHLMAYKDRSTS 2388

  Fly  1461 ICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYST 1525
            :||.|..::||..:||:....::|||:|.:.:|..|:|.:..||.:..:...|:|.| |.:....
Mouse  2389 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWRIISEEVQNKCSVILT-SHSMEEC 2452

  Fly  1526 PAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTT 1588
            .||  |:|.:.......||..:.::..:...:   ..::||..     :..|..|..|..:....
Mouse  2453 EALCTRLAIMVNGRFQCIGSLQHIKSRFGRGF---TVKVHLKN-----NKVSMETLTKFMQLHFP 2509

  Fly  1589 GTLLRHKH---QEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRI 1650
            .|.|:.:|   .|:....|           .|.:.|:|
Mouse  2510 KTYLKDQHLSMLEYHVPVT-----------AGGVANIF--------------------------- 2536

  Fly  1651 VDTLHRNKQ--DFYSFSVSQPSVNSVFLSIHR-QKS 1683
             |.|..||.  :..:|.|||.::..||::..: |||
Mouse  2537 -DLLETNKTALNITNFLVSQTTLEEVFINFAKDQKS 2571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	121/521 (23%)
		ABC_subfamily_A	519..737	CDD:213230	66/219 (30%)
		P-loop_NTPase	1330..1517	CDD:422963	52/187 (28%)
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468	56/295 (19%)
		NosY	<1108..1269	CDD:224196	40/189 (21%)
		ZnuC	1346..1570	CDD:224046	67/224 (30%)
		ABC_subfamily_A	1350..1565	CDD:213230	66/215 (31%)
		ABC2_membrane_3	<1913..2174	CDD:289468	55/283 (19%)
		CcmA	2253..2567	CDD:224054	86/367 (23%)
		ABC_subfamily_A	2254..2477	CDD:213230	62/229 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010