DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and abca3b

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	1870	Identity:	386/1870 - (20%)
Similarity:	708/1870 - (37%)	Gaps:	387/1870 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FCLLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSLIG 73
            |.||:|||:.:||...||.::.:.||::.|..|:.:|.
Zfish     7 FGLLLWKNYIQQKRQILVTLVEIALPLLFSAILIVLRQ--------------------------- 44

  Fly    74 KIQERRAKMASKQRNFTTNVFIP-----DIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDFEN 133
            |:.......|:..::|..|...|     .:::|:.|.:.:.::::..|....|......:..||.
Zfish    45 KVSFTNYPNATHYQSFPLNGLPPLLCYQQLQLAYVPANASVVQQIAQDVQQNLQSCIKNVRGFET 109

  Fly   134 CND----MRIHAASEHYLASVCFRNV----DESLNGLPTVLNFAIIM-----------PSELRNY 179
            ...    ::....|...||::.|.:.    ||.   ||..:::.:..           .|||...
Zfish   110 EEQFEEFVKTDPESGKILAAIVFEHPFSHDDEP---LPLQVSYHLRFTYSPRNAPAREKSELNPN 171

  Fly   180 EDTWIGDSWKETT--TLMDRDVAEEDEFDEDGYTDYMGEGFVPLQY----HISMQFLRATASKVE 238
            .|.    .|...:  .|.......|......|...|..|||:.:||    .|.|.:.|:.|..:.
Zfish   172 NDM----DWHTLSLFPLFQMPGPREQHDPHGGTPGYYREGFLQVQYAVDRAIMMAYNRSAAMALF 232

  Fly   239 KLPKVVMRRFNENPNVLLSE---GIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNA 300
            ...:|::.|| ..|..:...   .|...:.||::|.|.:....:...:|:|:|...:..::::..
Zfish   233 DQTQVLLSRF-PYPAFIYDVFILAIQNQLPLLLVLSFTYTALNIVRAVVQEKERKLKEYMRMMGL 296

  Fly   301 SATLQMAAWFFNVFTHFLITSLLITIL--LKIEWNGATAAVNKCPWPILL-CFLISYGCSVTSLI 362
            |..|..:|||...|....|:...:|:|  :|:..|||....:.   |.|: .||:.:..|..:..
Zfish   297 SNWLHWSAWFLMFFLFLSISIFFVTVLFCVKVSPNGAVLTYSD---PTLVFVFLLVFAISTINFS 358

  Fly   363 ILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDGPDVFYGFATVLLCNVSFSRGLSKI 424
            .:::....|:.||......|:.|..||   |..:.:|||....|    :..|:.||:.:.|...|
Zfish   359 FMISVFFSRANVAAAAGGFIYFLSYLPYVFLWPRYDLLSHAQKV----SACLISNVAMAMGAQLI 419

  Fly   425 FYIE-------------------DYTLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAM 470
            ...|                   |::|...||..:.       ..:...:|.:||:.:|.....:
Zfish   420 GMFEGKGTGIQWHNLFEAVTVDDDFSLAQVIGLLLL-------DALLYGLVAWYVEAVFPGEYGV 477

  Fly   471 IFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAEALIE--------------F 521
              ....||:       :|..|..:...|..||.:..|....|.|....:|              .
Zfish   478 --PQPWYFF-------ILPSYWCSSPRVAFLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRL 533

  Fly   522 RGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQ 586
            ..|::..:.|...|:|:|||::.|::..|||||.:||:|.:.||.|...|..|..|::|::|...
Zfish   534 AKVFKVGNKSKEAVRDLTLNMFEGQITVLLGHNGAGKTTTLSMLTGLFPPSSGRAYINGYDICQD 598

  Fly   587 RKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDL 651
            .....::..:...:..||..|.|.:||:|.::|:|..:.:...|...::|.|.|||........|
Zfish   599 MALIRRSLGLCPQHDVLFDNLTVREHLLFYTQLKGYPREKIPGEVDRIIRILNLEDKRNAKCKTL 663

  Fly   652 TIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIA 716
            :.|.:|.|....|..|.:::|:||:|..|:|.......:.|:..:|:.|:|..|::....|..:.
Zfish   664 SGGMKRKLSIGIALIGDSKVVMLDEPTSGMDPSARRATWDLLQGEKRGRTILLTTHFMDEADLLG 728

  Fly   717 DRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCAS 781
            |||.:::.|:||..|:...|.......|.::|..:..|:..::...:..::|:..::|......|
Zfish   729 DRIAIMASGELQCCGSPLFLKNKYGAGYHMVIVKDAFCNVSEITRLVHMYVPDATLESSAGAELS 793

  Fly   782 FLVKHKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQ---PGLQ-- 841
            :::..:..:....|...|...:::|.:.|:.....:::::...:.....|:|:...   |.||
Zfish   794 YILPKESTSRFELLFAELEMNRDELGIASYGASVTTMEEVFLRVGKLVDSSLDIQAIQLPALQYQ 858

  Fly   842 -----------------------------TLLASRQQSAK----RRFIIPTMYLLEELRQLLIAD 873
                                         |:::....:.|    .|..:...|.:...|.|.  .
Zfish   859 HERRSHDWTMDDSSSISGMTDVTDFTDSCTMISEDGSNIKLNTGARLYMQQFYAMFLKRALY--S 921

  Fly   874 TRNW------FLPILKLTLPSLVVVWTL----SMPYFWHNCRQPGHITFPMSDHGDGIILMQKDT 928
            .|||      ||..|..|:.:|||..:|    |.|......:|.|....|::
Zfish   922 WRNWKVMVAQFLVPLIFTVLALVVARSLPSSHSSPQLRLALKQYGQTHVPVA------------- 973

  Fly   929 LDSELLVASEMYAKVGVTEVDK-----TVDITTF----IYNYEYKNSLLSDADIMEAVIFSNVQI 984
            :::.....:.:.|::..|::..     ..:||.|    :||.:.:....::..::.|. |.:..:
Zfish   974 VEANAGPLASLLAEIYTTQLPSQNAIAAPNITDFSEYVLYNAQREGGAFNEHCVVGAA-FRSSDV 1037

  Fly   985 EVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASC 1049
            ...||.:..||...:|....|:|.......:|.|:...:.:|.:...|.|..|:........|..
Zfish  1038 IGYFNNQGYHTPATALMLVDNALFKLLAGPNASIQTGNDPMPRNVSETAQSQLSESQTGFAIAIN 1102

  Fly  1050 LSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIFFH 1114
            |.:....:.|...|.:...|..:..:|:.::|    |.:..|....||
Zfish  1103 LMYGMASLASTFALLLVSERSVKSKHVQQVSG----VYLTNFWFSALL----------------- 1146

  Fly  1115 WDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFVYL-----KVLLAYSLGILVYIAV 1174
            |||     |:.....::.::...|||:...:....:.|:.|:.|     .:.|.|.:..|...|.
Zfish  1147 WDL-----INFLLPCLLMLVVFRVFSVKAFVAQNHLVDVLFLLLLYGWAVIPLMYLMSFLFSTAA 1206

  Fly  1175 KELRPFTNPN----TAHFLLLDFHPFYALLHNLMRIASISEKIWL-----C---SDRQIYETSVY 1227
            ......|..|    ||.||.:.......|  ||:.::.:.:|::|     |   |..:.|:....
Zfish  1207 TAYTRLTIFNIISGTATFLAVTIMTIPEL--NLLHLSHLLDKVFLIFPNYCLGMSFTEFYQNYEM 1269

  Fly  1228 ADQCNTIP---NCCDDDAQEFYHL---------------RYLCCVYLLLVVVWISIFIF------ 1268
            ...|.:.|   ..|     ::|::               |:|..:.|..||..|.:|:.
Zfish  1270 ITFCTSSPLAKYIC-----KYYNITYQMNYFSMEEPGVGRFLVALSLQGVVFIILLFLIELRCIR 1329

  Fly  1269 LKSHMVKRRPR---------QPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNH 1324
            |..::.:||.:         ||:     |.|...::.  .::|...:..:.:.....|..|.:.:
Zfish  1330 LLLNLCRRRKKALLLAEEALQPE-----DRDVAEERK--RVLECQPVVESMVGSPLVVQELSKMY 1387

  Fly  1325 IESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSG-RIIS 1388
            ...::|            .|:..:...|.:.:...:.|.||.||:...|.:.|..:.:|| ..|.
Zfish  1388 SGGQSL------------LAVDRLSLAVGKGECFGLLGFNGAGKTTTFKMLTGDESITSGDAFID 1440

  Fly  1389 SKTVPFKSKDLDSCHMVGYSAQEFQTMQLMTILETWDLILRIRR-------------SKQISFRA 1440
            ..::....|.:.  ..:||..|....:..||..||..:..|:|.             .:.:....
Zfish  1441 GYSILTDVKKVQ--QRIGYCPQFDAVLDHMTGRETLSMYARLRGIPEKYVTACVENVLRSLLLEP 1503

  Fly  1441 EATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIH 1505
            .|.||.:.:             |.|..::||.|:||:....:|.||:|.|.:|.|::|.:...|.
Zfish  1504 HADKLVRSY-------------SGGNKRKLSAGMALIGGPPVIFLDEPSTGMDPVARRLLWDAIT 1555

  Fly  1506 DLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYM-----VETRIH 1563
            ..|..|.:||.| |.:.....||  |:|.:.......:|..:.::..:.|.|.:     |||.:.
Zfish  1556 RTRESGKAIIIT-SHSMEECEALCTRLAVMVNGQFKCLGSPQHLKSKFGSGYTLLAKVRVETELE 1619

  Fly  1564 LAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEF-SAAFTDSADRWKYLKLCGVIENVFPHAI 1627
            .::|....|| .:||        ..|:||:.:||.. ....||....|  .::.||:|..
Zfish  1620 ESDLQLFKDF-IEST--------FPGSLLKDEHQGMVHYHLTDKTLTW--AQVFGVLETA----- 1668

  Fly  1628 IKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFYSFSVSQPSVNSVFLS 1677
                                        :.|.....:.|||.|:..||||
Zfish  1669 ----------------------------KEKYSIEDYCVSQISLEQVFLS 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	125/504 (25%)
		ABC_subfamily_A	519..737	CDD:213230	65/231 (28%)
		P-loop_NTPase	1330..1517	CDD:422963	46/200 (23%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001	23/114 (20%)
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	360/1728 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020