DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and abca1a

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_001296394.1	Gene:	abca1a / 558924	ZFINID:	ZDB-GENE-031006-12	Length:	2268	Species:	Danio rerio

Alignment Length:	2011	Identity:	400/2011 - (19%)
Similarity:	723/2011 - (35%)	Gaps:	591/2011 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GKIQERRAKMASKQRNFTTNVFIPD-IRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDF----- 131
            |..:|.|.|:    .||..|....| :|.....|::|....      .|||.:|.::.|.
Zfish   419 GMWEEMRPKI----WNFMENSEEMDLVRTLLQNNASARFFN------AKLSGTEWRVEDVSRFLS 473

  Fly   132 ENCNDMRIHAASEHYLASVCFRNVDE------------SLNGLPTVLNFAIIMPSELRNYEDT-- 182
            ::..|.|.|..:  |.....|...|:            :|:.|..|.|...::...:|..:|.
Zfish   474 KSSEDTRPHGTA--YTWREVFNETDQAIQTISRFMECVNLDKLEPVANEERLVNKSMRLLDDRKF 536

  Fly   183 WIG----DSWKETTTL---------MDRDVAEEDEFDEDGYTD------------YMGEGFVPLQ 222
            |.|    |....|:.|         ||.|..|.....:|||.|            |:..||..||
Zfish   537 WAGIVFPDMQSNTSDLPLNVNYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDLRYIWGGFTYLQ 601

  Fly   223 YHISMQFLRA-TASK------VEKLP----------KVVMRRFNENPNVLLSEGIGTSVVLLILL 270
            ..|....:|| |.||      ::::|          :|:.|                |:.|.:.|
Zfish   602 DVIEHGIIRALTGSKEKTGVYIQQMPYPCYVDDIFLRVMSR----------------SMPLFMTL 650

  Fly   271 GFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGA 335
            .:|:.|.|:...:|.|:|...:..::|:.....:...:||.:.....||::.|:.::||:.
Zfish   651 AWMYSVAIIIKGVVYEKEARLKETMRIMGLDNGILWLSWFISSLIPLLISAALLVLILKMG---- 711

  Fly   336 TAAVNKCPWP---ILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALPLL------ 391
                |..|:.   ::..||.|:.........|:::...|:.:|.....||:..|.||.:
Zfish   712 ----NLLPYSDPGVIYLFLSSFAVVTIMQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQ 772

  Fly   392 -----SKKELLSDGPDVFYGFATVLLC-------NVSFSRGLSKIFYIEDYTLGVTIGKYMFYRV 444
                 ..|.::|....|.:||......       .:.:|..||.....:.|.|..:|...:|
Zfish   773 NYVGFGAKIVVSLLSPVAFGFGCEYFALFEEQGVGIQWSNLLSSPMQEDSYNLTTSICLMLF--- 834

  Fly   445 SKSDFGIFVPIVCFYVQTIFCTLLAM----IFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQI 505
                ..:...::.:|::.:|.....:    .|.....:|..       :|...|.|.....|...
Zfish   835 ----DSVLYAVMTWYIEAVFPGQYGIPRPWYFPFTKSYWCG-------EKCGWTTSVPSNRKENA 888

  Fly   506 PEVSFSKTSA--EALIEFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGR 568
            ..|...:..|  :..:....:.:.|||....|..:||..|.|::.:.||||.:||:|.:.:|.|.
Zfish   889 EAVCIEEEPAHIDPGVYIENLMKIYSNGKVAVDGLTLGFYEGQITSFLGHNGAGKTTTMSILTGL 953

  Fly   569 TRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKA 633
            ..|..|..|:.|.:|.|......:|..:...:..||:.|.|.:|:.|.:||:|||..:.|.|.:.
Zfish   954 FPPTSGTAYIQGKDIRTDLNAIRQNLGVCPQHNVLFSMLTVEEHIWFYARLKGLSAEKVKSEMEQ 1018

  Fly   634 LLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKK 698
            ::..|.|.....:..|.|:.|.:|.|....||.||:::||||:|..|:|.......:.|:|..::
Zfish  1019 IVMDLGLPHKRTSRSNQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRQ 1083

  Fly   699 NRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLII----FGNEKCSFKDV 759
            .|:|..::::...|..:.|||.::|.|||...|:...|...|...|.|.:    |.....|.:..
Zfish  1084 GRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKDFDLSASSCRTS 1148

  Fly   760 YAFMATFIPEIEMDSILADCAS---FLVKHKYHTEL--INLIENL-------ARLKNDLN----- 807
            .:.::.....::.|..:::.:|   ....|:..|..  |:||.|:       |||..||.
Zfish  1149 SSTVSYSKGSLKKDDSVSESSSDAGLGSDHESETTTIDISLISNVIFKHVPTARLVEDLGHEITY 1213

  Fly   808 VYSFE----------IHECSIDDILASL----YTRDKSTLE------------------------ 834
            |..:|          .||  |||.|..|    |....:|||
Zfish  1214 VLPYESAKDGAFVELFHE--IDDRLTDLSISSYGISDTTLEEIFLKVAEDCGVDAETSDGTLPAR 1276

  Fly   835 ------FGQPGLQTLL-----------------ASRQQ-----------------SAKRRFIIPT 859
                  ||..  |:.|                 .||:.                 |.||:..:..
Zfish  1277 RNRRHAFGDH--QSCLKPFTEDDFDFNDSEGDPESRETDWLDGADGKGSYQVKGWSLKRQQFVAL 1339

  Fly   860 MYLLEELRQLLIA-DTRNWFLPILKLTLPSLVV----VWTLSMPYFWHNCRQPG----------H 909
            ::     ::||.| .:|..|  ..::.||::.|    |::|.:|.|.   :.|.          .
Zfish  1340 LW-----KRLLYARRSRKGF--FAQIVLPAVFVCIALVFSLIVPPFG---KYPSLALEPSMYEEQ 1394

  Fly   910 ITF-----PMSDHGDGIILMQKDT-------LDSELLVASEMYAKVG---VTEVDKTVDITTFIY 959
            .||     |...|.:.::...||:       .|.:...:.....|.|   |.||.::::......
Zfish  1395 FTFISNDAPEDRHTNRLLDALKDSPAYTDQCTDGKNTASRSCPIKDGEWLVPEVTESIEAIFLNG 1459

  Fly   960 NYEYKN---------------------------------------SLLSDADIMEAVIFSNVQI- 984
            |:..:|                                       ..||..:|.:.::.:..||
Zfish  1460 NWSMENPSPLCECSCEGRKKMLPECPPGAGGLPPPQIKVTHDETLQNLSGRNISDYLVKTYAQII 1524

  Fly   985 -EVLFNTKW---------------PHTAP--DSLAQALNSLAVAF-------------------- 1011
             :.|.|..|               ....|  |.|..|::.:...|
Zfish  1525 GKSLKNKLWVNEFRYGGFSLGARNTQALPPGDELTDAISHIRSRFSLESGTAADRFLGSLSTFIR 1589

  Fly  1012 -IDGDAGIKV------------ELEVLPFSTI-------------------HTLQL------H-- 1036
             :|.:..:|:            .|.|:..:.:                   |.|.|      |
Zfish  1590 GLDTNNNVKIWFNNKGWHSIGSFLNVMNNAVLRANLPPGLDRSKFGINAFNHPLNLTKEQLSHVA 1654

  Fly  1037 LNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELLVVLL 1101
            |.....|::.:.|:.|...|:.:..::.:...|..:..:::.|:|:...:..:|..::::...::
Zfish  1655 LMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPFLYWLANFVWDMCNYIV 1719

  Fly  1102 ALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFVYLKVLLAYSL 1166
               |..:.:|                ::|.|...|.|.|.|:.:..:         |.:|..:|:
Zfish  1720 ---PATLVII----------------IFVCFQQEAYVSSTNLPVLAL---------LLLLYGWSI 1756

  Fly  1167 GILVYIAVKELRP----FTNPNTAHFLLLDFH----------PFYALLHNLMRIASISE---KIW 1214
            ..|:|       |    |..|:||:.:|...:          .|...|.....|..|::   .::
Zfish  1757 TPLMY-------PASFFFKIPSTAYVVLTSVNILIGINGSVSTFVLELFGSNEIGGINDILKNVF 1814

  Fly  1215 L-----CSDRQIYETSVYADQCNTIPNCCDDDAQE-FYHLRYLCCVYLLLV-----------VVW 1262
            |     |..|.:.:         .:.|....||.| |...|:...:...:|           |::
Zfish  1815 LIFPHFCLGRGLID---------MVKNQAMADALERFGENRFRSPLAWDMVGKNLFAMAIEGVIF 1870

  Fly  1263 ISIFIFLKSHM-VKRRPRQPKY--FWDSDPD-SKYDQNIL------HIMEPSELENTWIHEKSRV 1317
            .||.:.::... :|.|....|.  ..:.|.| ::..|.||      .|:|..:|  |.::::.:
Zfish  1871 FSITVLIQYRFCIKARSLSTKLKPIGEEDEDVARERQRILGGGGQTDILELRQL--TKVYKRKQ- 1932

  Fly  1318 STLERNHIESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPS 1382
                                    |.|:..:...:...:...:.|.||.||:...|.:.|....:
Zfish  1933 ------------------------KPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLTGDSVVT 1973

  Fly  1383 SGR-IISSKTVPFKSKDLDSCHM-VGYSAQEFQTMQLMTILETWDL--ILRIRRSKQISFRAEAT 1443
            ||. .::..:|   ..::|..|. :||..|......|:|..|..:.  |||....|::
Zfish  1974 SGEAYLAGNSV---LTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEV------- 2028

  Fly  1444 KLCKI-------FGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSML 1501
              ||:       .||.||...:....|.|.:::||..:||:....::.||:|.|.:|..::|::.
Zfish  2029 --CKVADWGIRKLGLMKYVDKAAGSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRALW 2091

  Fly  1502 HIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHL 1564
            :.|..:.:.|.|::.| |.:.....||  |||.:.......:|..:.: :|.:...|.:..|:..
Zfish  2092 NCILSIIKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFRCLGSVQHL-KNKFGDGYTIILRVAG 2154

  Fly  1565 AE--LGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAI 1627
            |:  |...::|..:.         ..|:.|:.||:..
Zfish  2155 ADPRLEPVMEFIERE---------LPGSTLKEKHRNM---------------------------- 2182

  Fly  1628 IKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSIHRQKSNKD 1686
                    :.:.|||.:..::||.:.|.:||:..:  .:||||.:::.||::..:.:|::|
Zfish  2183 --------LQYQLSSSLTSLARIFNILSKNKEQLHIEDYSVSQTTLDQVFVNFAKDQSDED 2235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	118/492 (24%)
		ABC_subfamily_A	519..737	CDD:213230	68/217 (31%)
		P-loop_NTPase	1330..1517	CDD:422963	45/197 (23%)
abca1a	NP_001296394.1	rim_protein	1..2233	CDD:130324	398/2007 (20%)
		ABC_subfamily_A	904..1122	CDD:213230	68/217 (31%)
		ABC_subfamily_A	1919..2139	CDD:213230	56/260 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920