Protein Alignment CG43672 and Abca1

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_038965774.1
• Gene: Abca1 / 313210
• RGDID: 631344
• Length: 2263
• Species: Rattus norvegicus
• Alignment Length: 2023
• Identity: 392/2023 - (19%)
• Similarity: 710/2023 - (35%)
• Gaps: 594/2023 - (29%)

  Fly    37 SSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSLIGKIQERRAKMASKQRNFTTNVFIPDIRVA 101
            ||..:..:|:..||...|..  .|.:|....|::     |:..|.:|....         |::
  Rat   429 SSQEMDLVRTMLDSRGNDQF--WERKLDGLDWTA-----QDIMAFLAKNPE---------DVQ-- 475

  Fly   102 FAPNSNAALRRLMGDALGKLSMSEDKIVDFENCNDMRIHAASEHYLASVCFRNVDESLNGLPTVL 166
             :||.:....|   :|..:.:.:...|..|..|.::                   ..|..:||.:
  Rat   476 -SPNGSVYTWR---EAFNETNQAIQTISRFMECVNL-------------------NKLEPIPTEV 517

  Fly   167 NFAIIMPSELRNYEDTWIGDSWKETT-------------TLMDRDVAEEDEFDEDGYTD------ 212
            .. |....||.:....|.|..:...|             ..||.|..|.....:|||.|
  Rat   518 RL-INKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRAD 581

  Fly   213 ------YMGEGFVPLQYHISMQFLRA-------TASKVEKLP----------KVVMRRFNENPNV 254
                  |:..||..||..:....:|.       |...|:::|          :|:.|
  Rat   582 PFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFLRVMSR-------- 638

  Fly   255 LLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLI 319
                    |:.|.:.|.:::.|.::...||.|:|...:..::|:.....:...:||.:.....|:
  Rat   639 --------SMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLV 695

  Fly   320 TSLLITILLKIEWNGATAAVNKCPW--PILLCFLISYGCSVTSL-IILMTSAMRRSRVAMVMAPI 381
            ::.|:.|:||:.        :..|:  |.::...:|....||.| ..|:::...|:.:|.....|
  Rat   696 SAGLLVIILKLG--------DLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRTNLAAACGGI 752

  Fly   382 IWILLALPLLSKKELLSDGPDVFYGFA----TVLLCNVSFSRGLSKIFYIEDYTLGV-------- 434
            |:..|.||.     :|......:.||:    ..||..|:|..|.......|:..:||
  Rat   753 IYFTLYLPY-----VLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFKS 812

  Fly   435 ---TIGKYMFYRVSKSDFGIFV-PIVCFYVQTIF-------------CTLLAMIFENNAYFWLAI 482
               ..|..:...||...|..|: .::.:|::.:|             ||         ..:|..
  Rat   813 PVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCT---------KSYWFG- 867

  Fly   483 RVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVVQD-ITLNVYAGE 546
              :.:.:|.|...|..|..:..:.|   ..|..:..:..:.:.:.|.:...|..| :.||.|.|:
  Rat   868 --EEIDEKSHPGSSQKGASEICMEE---EPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQ 927

  Fly   547 VVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLD 611
            :.:.||||.:||:|.:.:|.|...|..|..|:.|.:|.::.....:|..:...:..||..|.|.:
  Rat   928 ITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIRQNLGVCPQHNVLFDMLTVEE 992

  Fly   612 HLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWE-KTLVNDLTIGQRRVLQFLCAFAGGNQIVILD 675
            |:.|.:||:|||:...|.|.:.:...:.|...: |:..:.|:.|.:|.|....||.||:::||||
  Rat   993 HIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILD 1057

  Fly   676 KPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRML 740
            :|..|:|.......:.|:|..::.|:|..::::...|..:.|||.::|.|||...|:...|...|
  Rat  1058 EPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQL 1122

  Fly   741 NESYRLIIFGNEKCSFKDVYAFMAT-------------FIPEI-----------EMDSILA---D 778
            ...|.|.:..      |||.:.:::             .:||:           |:..::|   |
  Rat  1123 GTGYYLTLVK------KDVESSLSSCRNSSSTVSCLKKVVPELPAAGQSGGRGGEVQRLVALTQD 1181

  Fly   779 CASFLVKHKYHTELINLIENLA--------------------------RLKNDLNVYSFEIHECS 817
            .::.....:.|.....|:|::.                          || :||.:.|:.|.|.:
  Rat  1182 VSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRL-SDLGISSYGISETT 1245

  Fly   818 IDDILASL---------------------------------YTRD---------------KSTLE 834
            :::|...:                                 :|.|               ::.|.
  Rat  1246 LEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDLDPESRETDLL 1310

  Fly   835 FGQPGLQTLLASRQQSAKRRFIIPTMYLLEELRQLLIA-DTRNWFLPILKLTLPSLVV----VWT 894
            .|..|..:......:..:::|:.    ||  .::|||| .:|..|  ..::.||::.|    |::
  Rat  1311 SGMDGKGSYQLKGWKLTQQQFVA----LL--WKRLLIARRSRKGF--FAQIVLPAVFVCIALVFS 1367

  Fly   895 LSMPYF----------W-HN-----------------------CRQPGHIT-------------- 911
            |.:|.|          | :|                       .:.||..|
  Rat  1368 LIVPPFGKYPNLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPNTPCL 1432

  Fly   912 -------------------------------------------FPMSDHGDGII---LMQKDTLD 930
                                                       .|:...|.|.:   ..::.|.|
  Rat  1433 VGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTAD 1497

  Fly   931 ----------SELLVASEMYAKVGVTEVDKTVDITTFIY---------------NYEYKNSLL-- 968
                      |:.||  :.|.::....:...|.:..|.|               :.|..|::.
  Rat  1498 ILQNLTGRNISDYLV--KTYVQIIAKSLKNKVWVNEFRYGGFSLGVSDSQALPPSQEVNNAIKQM 1560

  Fly   969 ---------SDAD--------IMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFID--- 1013
                     |.||        .|..:...| .::|.||.|..|.....|....|::..|.:.
  Rat  1561 KKLLKLTKDSSADRFLSSLGRFMTGLDTKN-NVKVWFNNKGWHAISSFLNVINNAILRANLQKGE 1624

  Fly  1014 --GDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYV 1076
              ...||......|..:.....::.|.....|::.:.|:.|...|:.:..::.:...|..:..::
  Rat  1625 NPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHL 1689

  Fly  1077 ELIAGMPTIVLIVAFLIYELL-VVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFS 1140
            :.|.|:..::..::..::::. .|:.|...:.|.:.|.....:..:|:.:.::.::      ::.
  Rat  1690 QFICGVKPVIYWLSNFVWDMCNYVVPATLVVIIFICFQQKSYVSSTNLPVLALLLL------LYG 1748

  Fly  1141 LNILITIMPIS---DMPFVYLKVLLAYSL--GILVYIAVKELRPFTNPN--------------TA 1186
            .:|...:.|.|   .:|.....||.:.:|  ||...:|...|..|||..              ..
  Rat  1749 WSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKFNDINDILKSVFLIFP 1813

  Fly  1187 HFL----LLDFHPFYALLHNLMRIAS---ISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQE 1244
            ||.    |:|.....|:...|.|...   :|...|....|.::..:|..
  Rat  1814 HFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG---------------- 1862

  Fly  1245 FYHLRYLCCVYLLLVVVWISIFIFLKSHMVKRR--PRQPKYFWDSDPDSKYD-QNILH------I 1300
                     |...||.|.|....|::...||.|  |..     |.|.|.:.: |.||.      |
  Rat  1863 ---------VVFFLVTVLIQYRFFIRPRPVKARLPPLN-----DEDEDVRRERQRILEGGGQNDI 1913

  Fly  1301 MEPSELENTWIHEKSRVSTLERNHIESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANG 1365
            :|..||  |.|:.:.|                         |.|:..|...:...:...:.|.||
  Rat  1914 LEIKEL--TKIYRRKR-------------------------KPAVDRICVGIPPGECFGLLGVNG 1951

  Fly  1366 TGKSVLLKTILGIYTPSSGRIISSKTVPFKSKDLDSCHMV----GYSAQEFQTMQLMTILETWDL 1426
            .||:...|.:.|....:.|..:.:     |:..|.:.|.|    ||..|.....:|:|..|..:.
  Rat  1952 AGKTSTFKMLTGDTAVTRGDALLN-----KNSILSNIHEVHQNMGYCPQFDAITELLTGREHLEF 2011

  Fly  1427 --ILRIRRSKQISFRAE--ATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDD 1487
              :||....|::....|  ..||    ||.||.....|..|.|..::||..|||:....::.||:
  Rat  2012 FALLRGVPEKEVGKVGEWAIRKL----GLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLDE 2072

  Fly  1488 PFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQN 1550
            |.|.:|..::|.:.:....:.:.|.|::.| |.:.....||  |||.:.......:|..:.: :|
  Rat  2073 PTTGMDPKARRFLWNCALSIIKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFRCLGSVQHL-KN 2135

  Fly  1551 YYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKL 1615
            .:...|.:..||                      ||:...|  ...|||...
  Rat  2136 RFGDGYTIVVRI----------------------AGSNPDL--KPVQEFFGL------------- 2163

  Fly  1616 CGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSI 1678
                  .||.:::|......:.:.|.|.:..::||...|.::|:..:  .:||||.:::.||::.
  Rat  2164 ------AFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF 2222

  Fly  1679 HRQKSNKD 1686
            .:.:|:.|
  Rat  2223 AKDQSDDD 2230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	120/499 (24%)
		ABC_subfamily_A	519..737	CDD:213230	65/219 (30%)
		P-loop_NTPase	1330..1517	CDD:422963	47/194 (24%)
Abca1	XP_038965774.1	rim_protein	1..2238	CDD:130324	392/2023 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920