Protein Alignment CG43672 and Abca4

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_063138015.1
• Gene: Abca4 / 310836
• RGDID: 1309445
• Length: 2312
• Species: Rattus norvegicus
• Alignment Length: 2054
• Identity: 409/2054 - (19%)
• Similarity: 723/2054 - (35%)
• Gaps: 560/2054 - (27%)

  Fly    49 DSNMRDYSIRAEAELLEFSWSSLIGKIQE----RRAKMASKQRNFTTNVFIPDIRVA--FAPNSN 107
            ||..||.:...:.....|. :|||..::.    :.|..|:|.......:|.||...|  ...|:|
  Rat   352 DSTRRDPTYSYDKRTTSFC-NSLIQSLESNPLTKIAWRATKPLLMGKILFTPDSPAARRLLKNAN 415

  Fly   108 AALRRLMGDALGKLSMSEDKI-----VDFENCNDMRIHAASEHYLASVCFRNVDESLNGLPT--V 165
            :....|  |.:.||..:.:::     ..||....|.:...:..:.....|.|......|:.|  :
  Rat   416 STFEEL--DRVRKLVKAWEEVGPQIWYFFEKSTQMAVIRDTLQHPTVKDFINRQLGEEGITTEAI 478

  Fly   166 LNFAIIMPSELRNYEDTWIGDSWKETTTLMDRDVAEEDEFDE----DGYTDYMGE---------- 216
            |||....|.|  |..|......|::...:.||.:...:::.|    |.:..|..|
  Rat   479 LNFFPNGPRE--NQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYDDEVQLTQRALSL 541

  Fly   217 --------GFV-PLQY--------HISMQFLRATASKVEKLPKVVMRRFNENPNV---------- 254
                    |.| |..|        |:..: :|.....|||..|:..|.::..|..
  Rat   542 LEENRFWAGVVFPDMYPWTSSLPPHVKYK-IRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIW 605

  Fly   255 --------LLSEGIGTS--------------------------VVL------LILLGFMFPVTIL 279
                    ::.:||..|                          ::|      .::|.:::.|::.
  Rat   606 GGFAYLQDMVEQGIVRSQTPAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMT 670

  Fly   280 TTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPW 344
            ...||.|:||..:..||....|..:....||.:.|:...::..|:|:.:   .:|.....:. |:
  Rat   671 VKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTLFI---MHGRILHYSD-PF 731

  Fly   345 PILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP--------------LLSKKE 395
             ||..||:::..:......|.::...::.:|...:.:|:..|.||              |.:...
  Rat   732 -ILFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTADLKTTVS 795

  Fly   396 LLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTLGV---TIGK-------YMFYRVSKS--- 447
            |||   .|.:||.|..|  |.|          |:..||:   .|||       :.|....|.
  Rat   796 LLS---PVAFGFGTEYL--VRF----------EEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLL 845

  Fly   448 DFGIFVPIVCFYVQTIF----CTLLAMIFENNAYFWL-----AIRVKNLLKKYHATRSAVGRLKR 503
            |..:: .::.:|:..:|    .|.|...|.....:||     :.|.:..|:|.......:
  Rat   846 DAALY-GLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEI----- 904

  Fly   504 QIPEV------SFSKTSAEALIEFRGVWQK------YSNSTYVVQDITLNVYAGEVVALLGHNAS 556
            :.||.      ||.:.....|:.  ||..|      ...|...|..:.:..|..::.|.||||.:
  Rat   905 EDPEYPEGMNDSFFERELPGLVP--GVCVKNLVKVFEPGSRPAVDRLNITFYENQITAFLGHNGA 967

  Fly   557 GKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRG 621
            ||:|.:.:|.|...|..|.:.:.|.:|........::..:...:..||..|.|.:|::|.::|:|
  Rat   968 GKTTTLSILTGLLPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKG 1032

  Fly   622 LSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRT 686
            .|..||:||.:|:|....|.........||:.|.:|.|....||.|.:::|:||:|..|:|....
  Rat  1033 RSWEEARLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSR 1097

  Fly   687 SLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGT--VKKLC-----------R 738
            ...:.|:|..:..|:|..::::...|..:.|||.::|:|:|...||  ..|.|           :
  Rat  1098 RSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRK 1162

  Fly   739 MLN-ESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYH------------T 790
            |.| :|.|....|...|:.|...|.....:.||..:.:|......|....||            .
  Rat  1163 MKNIQSQRCGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVECIGQ 1227

  Fly   791 ELINLIEN--------------LARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEF------ 835
            |||.|:.|              |.....||.:.||.|.:..:::|...:....:|..:|
  Rat  1228 ELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSESGSKFVGGTQQ 1292

  Fly   836 -------------------------------------GQPG--------------------LQTL 843
                                                 |||.                    :|.|
  Rat  1293 KREHTGLRHPCSAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGARLILQHVQAL 1357

  Fly   844 LASRQQSAKR-------RFIIPTMYL--------------------------------------- 862
            |..|...|.|       :.::|..::
  Rat  1358 LVKRFHHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQFTFFSMDEPN 1422

  Fly   863 ---LEELRQLLI--------------------ADTRNWFLPILKLTLPSLV--VVWTLSMPYFWH 902
               ||.|..:|:                    .:..:|..|.:...:..|.  ..||.:.|....
  Rat  1423 NEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPNITHLFQKQKWTAAHPSPAC 1487

  Fly   903 NC-RQPGHITFPMSDHGDGII-----------LMQ-------------------KDTLDSELLVA 936
            .| .:...|..|....|.|.:           ::|                   :.:|.|:..|.
  Rat  1488 KCSTREKLIMLPECPEGAGGLPPPQRIQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVN 1552

  Fly   937 SEMYAKVGVTEVDKTVDITTFIYNYEYKNSLLSDADIMEAV-------------------IFSNV 982
            .:.|.  |::...|..||.   .:.|.....|||...|..|                   :.:..
  Rat  1553 EQRYG--GISIGGKLPDIP---ISGEALVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLETKD 1612

  Fly   983 QIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDA-----GIKVELEVLPFSTIHTLQLHLNIDGY 1042
            .|:|.||.|..|.....|..|.|::..|.:..|.     ||.|..:.|..:.....::.:.....
  Rat  1613 NIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRDPEEYGITVISQPLNLTKEQLSEITVLTTSI 1677

  Fly  1043 DLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGM-PTIVLIVAFLIYELLVVLLALFPI 1106
            |.:.|.|:.|...|:.:..:|::...|..:..:::.|:|: ||...:..||
  Rat  1678 DAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFL-------------- 1728

  Fly  1107 NIAVIFFHWDLL---MDSNIHIYSVYVMFIIAACVFSLNI--LITIMPI---SDMPFVYLKVLLA 1163
                    ||::   :.:.: :..:::.|...|...:.|:  |:|::.:   :.:|.:|....|
  Rat  1729 --------WDIMNYAVSAGL-VVGIFIGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFL- 1783

  Fly  1164 YSLGILVYIAVKELRPFTNPNTA-----------HFLLLDF----------HPFYALLHNLMRIA 1207
            :.:....|:|:.....|...|::           :.:||.|          .|.:.|...|:.:|
  Rat  1784 FDVPSTAYVALSCANLFIGINSSAITFVLELFENNRMLLRFSATLRELLIVFPHFCLGRGLIDLA 1848

  Fly  1208 SISEKIWLCSDRQIYETSVYA---DQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFL 1269
             :|:.:          |.:||   ::.:..|...|...:....:.....||.||.:: |....||
  Rat  1849 -LSQAV----------TDIYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLL-IQHHFFL 1901

  Fly  1270 KSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEH 1334
             :..:....|:|.:  |.|.|         :.|          |:.||.:   ...:|..|.:..
  Rat  1902 -TRWIAEPAREPVF--DEDDD---------VAE----------ERQRVMS---GGSKSDILKLNE 1941

  Fly  1335 LS-VFFGLKA-AIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKS- 1396
            |: |:.|..: |:..:...|:..:...:.|.||.||:...|.:.|..|.:||    ..|:..||
  Rat  1942 LTKVYSGSSSPAVDRLCVGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSG----DATIAGKSI 2002

  Fly  1397 -KDLDSCHM-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSL 1459
             .::...|. :||..|......|:|..|...|..|:|..........|....:..||..|.....
  Rat  2003 LTNISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLA 2067

  Fly  1460 SICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYS 1524
            ...|.|..::||..|||.....|:|||:|.|.:|..::|.:.:.|.::.|:|.:::.| |.:...
  Rat  2068 GTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLT-SHSMEE 2131

  Fly  1525 TPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGT 1587
            ..||  |:|.:.......:|..:.::..:...|      |...::.||          |:|....
  Rat  2132 CEALCTRLAIMVKGTFQCMGTIQHLKYKFGDGY------IVTMKIKSP----------KDDLLPD 2180

  Fly  1588 TGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVD 1652
                |....|.|...|..|..|.::            |::::        |.:.|.  .::||..
  Rat  2181 ----LNPVEQFFQGNFPGSVQRERH------------HSMLQ--------FQVPSS--SLARIFQ 2219

  Fly  1653 TL--HRNKQDFYSFSVSQPSVNSVFLSIHRQKSNKDAFP 1689
            .|  |::......:||:|.:::.||::..:|::.....|
  Rat  2220 LLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTETYDLP 2258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	124/519 (24%)
		ABC_subfamily_A	519..737	CDD:213230	64/225 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	51/191 (27%)
Abca4	XP_063138015.1	None