Protein Alignment CG43672 and Abca4

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_001101191.1
• Gene: Abca4 / 310836
• RGDID: 1309445
• Length: 2290
• Species: Rattus norvegicus
• Alignment Length: 2046
• Identity: 406/2046 - (19%)
• Similarity: 720/2046 - (35%)
• Gaps: 558/2046 - (27%)

  Fly    61 AELLEFSW------SSLIGKIQERRAKMASKQRNFTTNVFIPDI--RVAFAPNSNAALRRLMG-- 115
            :.:..|:|      .:.:|....||....|..:..|.....|.:  ::.|.|:|.||.|.|..
  Rat   332 SRVFSFNWYEDNNYKAFLGIDSTRRDPTYSYDKRTTWRATKPLLMGKILFTPDSPAARRLLKNAN 396

  Fly   116 ------DALGKLSMSEDKI-----VDFENCNDMRIHAASEHYLASVCFRNVDESLNGLPT--VLN 167
                  |.:.||..:.:::     ..||....|.:...:..:.....|.|......|:.|  :||
  Rat   397 STFEELDRVRKLVKAWEEVGPQIWYFFEKSTQMAVIRDTLQHPTVKDFINRQLGEEGITTEAILN 461

  Fly   168 FAIIMPSELRNYEDTWIGDSWKETTTLMDRDVAEEDEFDE----DGYTDYMGE------------ 216
            |....|.|  |..|......|::...:.||.:...:::.|    |.:..|..|
  Rat   462 FFPNGPRE--NQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYDDEVQLTQRALSLLE 524

  Fly   217 ------GFV-PLQY--------HISMQFLRATASKVEKLPKVVMRRFNENPNV------------ 254
                  |.| |..|        |:..: :|.....|||..|:..|.::..|..
  Rat   525 ENRFWAGVVFPDMYPWTSSLPPHVKYK-IRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGG 588

  Fly   255 ------LLSEGIGTS--------------------------VVL------LILLGFMFPVTILTT 281
                  ::.:||..|                          ::|      .::|.:::.|::...
  Rat   589 FAYLQDMVEQGIVRSQTPAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVK 653

  Fly   282 LIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPI 346
            .||.|:||..:..||....|..:....||.:.|:...::..|:|:.:   .:|.....:. |: |
  Rat   654 GIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTLFI---MHGRILHYSD-PF-I 713

  Fly   347 LLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP--------------LLSKKELL 397
            |..||:::..:......|.::...::.:|...:.:|:..|.||              |.:...||
  Rat   714 LFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTADLKTTVSLL 778

  Fly   398 SDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTLGV---TIGK-------YMFYRVSKS---DF 449
            |   .|.:||.|..|  |.|          |:..||:   .|||       :.|....|.   |.
  Rat   779 S---PVAFGFGTEYL--VRF----------EEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDA 828

  Fly   450 GIFVPIVCFYVQTIF----CTLLAMIFENNAYFWL-----AIRVKNLLKKYHATRSAVGRLKRQI 505
            .:: .::.:|:..:|    .|.|...|.....:||     :.|.:..|:|.......:.  ..:.
  Rat   829 ALY-GLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEIE--DPEY 890

  Fly   506 PEVSFSKTSAEALIEFRGVWQK------YSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKM 564
            ||.||.:.....|:.  ||..|      ...|...|..:.:..|..::.|.||||.:||:|.:.:
  Rat   891 PEDSFFERELPGLVP--GVCVKNLVKVFEPGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSI 953

  Fly   565 LYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKL 629
            |.|...|..|.:.:.|.:|........::..:...:..||..|.|.:|::|.::|:|.|..||:|
  Rat   954 LTGLLPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEARL 1018

  Fly   630 EAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLIL 694
            |.:|:|....|.........||:.|.:|.|....||.|.:::|:||:|..|:|.......:.|:|
  Rat  1019 EMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLL 1083

  Fly   695 DQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGT--VKKLC-----------RMLN-ESYR 745
            ..:..|:|..::::...|..:.|||.::|:|:|...||  ..|.|           :|.| :|.|
  Rat  1084 KYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQR 1148

  Fly   746 LIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYH------------TELINLIEN 798
            ....|...|:.|...|.....:.||..:.:|......|....||            .|||.|:.|
  Rat  1149 CGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVECIGQELIFLLPN 1213

  Fly   799 --------------LARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEF-------------- 835
                          |.....||.:.||.|.:..:::|...:....:|..:|
  Rat  1214 KNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSESGSKFVGGTQQKREHTGLR 1278

  Fly   836 -----------------------------GQPG--------------------LQTLLASRQQSA 851
                                         |||.                    :|.||..|...|
  Rat  1279 HPCSAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGARLILQHVQALLVKRFHHA 1343

  Fly   852 KR-------RFIIPTMYL------------------------------------------LEELR 867
            .|       :.::|..::                                          ||.|.
  Rat  1344 VRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQFTFFSMDEPNNEHLEVLA 1408

  Fly   868 QLLI--------------------ADTRNWFLPILKLTLPSLV--VVWTLSMPYFWHNC-RQPGH 909
            .:|:                    .:..:|..|.:...:..|.  ..||.:.|.....| .:...
  Rat  1409 DVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPNITHLFQKQKWTAAHPSPACKCSTREKL 1473

  Fly   910 ITFPMSDHGDGII-----------LMQ-------------------KDTLDSELLVASEMYAKVG 944
            |..|....|.|.:           ::|                   :.:|.|:..|..:.|.  |
  Rat  1474 IMLPECPEGAGGLPPPQRIQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYG--G 1536

  Fly   945 VTEVDKTVDITTFIYNYEYKNSLLSDADIMEAV-------------------IFSNVQIEVLFNT 990
            ::...|..||.   .:.|.....|||...|..|                   :.:...|:|.||.
  Rat  1537 ISIGGKLPDIP---ISGEALVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLETKDNIKVWFNN 1598

  Fly   991 KWPHTAPDSLAQALNSLAVAFIDGDA-----GIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCL 1050
            |..|.....|..|.|::..|.:..|.     ||.|..:.|..:.....::.:.....|.:.|.|:
  Rat  1599 KGWHALVSFLNVAHNAILRASLPKDRDPEEYGITVISQPLNLTKEQLSEITVLTTSIDAVVAICV 1663

  Fly  1051 SFCFCFIWSIPLLHMTLSRDGRYNYVELIAGM-PTIVLIVAFLIYELLVVLLALFPINIAVIFFH 1114
            .|...|:.:..:|::...|..:..:::.|:|: ||...:..||
  Rat  1664 IFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFL---------------------- 1706

  Fly  1115 WDLL---MDSNIHIYSVYVMFIIAACVFSLNI--LITIMPI---SDMPFVYLKVLLAYSLGILVY 1171
            ||::   :.:.: :..:::.|...|...:.|:  |:|::.:   :.:|.:|....| :.:....|
  Rat  1707 WDIMNYAVSAGL-VVGIFIGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFL-FDVPSTAY 1769

  Fly  1172 IAVKELRPFTNPNTA-----------HFLLLDF----------HPFYALLHNLMRIASISEKIWL 1215
            :|:.....|...|::           :.:||.|          .|.:.|...|:.:| :|:.:
  Rat  1770 VALSCANLFIGINSSAITFVLELFENNRMLLRFSATLRELLIVFPHFCLGRGLIDLA-LSQAV-- 1831

  Fly  1216 CSDRQIYETSVYA---DQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMVKRR 1277
                    |.:||   ::.:..|...|...:....:.....||.||.:: |....|| :..:...
  Rat  1832 --------TDIYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLL-IQHHFFL-TRWIAEP 1886

  Fly  1278 PRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLS-VFFGL 1341
            .|:|.:  |.|.|         :.|          |:.||.:   ...:|..|.:..|: |:.|.
  Rat  1887 AREPVF--DEDDD---------VAE----------ERQRVMS---GGSKSDILKLNELTKVYSGS 1927

  Fly  1342 KA-AIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKS--KDLDSCH 1403
            .: |:..:...|:..:...:.|.||.||:...|.:.|..|.:||    ..|:..||  .::...|
  Rat  1928 SSPAVDRLCVGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSG----DATIAGKSILTNISDVH 1988

  Fly  1404 M-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVL 1467
            . :||..|......|:|..|...|..|:|..........|....:..||..|........|.|..
  Rat  1989 QNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNK 2053

  Fly  1468 KRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RM 1530
            ::||..|||.....|:|||:|.|.:|..::|.:.:.|.::.|:|.:::.| |.:.....||  |:
  Rat  2054 RKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLT-SHSMEECEALCTRL 2117

  Fly  1531 ATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHK 1595
            |.:.......:|..:.::..:...|      |...::.||          |:|....    |...
  Rat  2118 AIMVKGTFQCMGTIQHLKYKFGDGY------IVTMKIKSP----------KDDLLPD----LNPV 2162

  Fly  1596 HQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTL--HRNK 1658
            .|.|...|..|..|.::            |::::        |.:.|.  .::||...|  |::.
  Rat  2163 EQFFQGNFPGSVQRERH------------HSMLQ--------FQVPSS--SLARIFQLLISHKDS 2205

  Fly  1659 QDFYSFSVSQPSVNSVFLSIHRQKSNKDAFP 1689
            .....:||:|.:::.||::..:|::.....|
  Rat  2206 LLIEEYSVTQTTLDQVFVNFAKQQTETYDLP 2236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	124/513 (24%)
		ABC_subfamily_A	519..737	CDD:213230	64/225 (28%)
		P-loop_NTPase	1330..1517	CDD:422963	51/191 (27%)
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	406/2046 (20%)
		ABC_subfamily_A	907..1126	CDD:213230	62/218 (28%)
		ABC_subfamily_A	1915..2135	CDD:213230	58/224 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920