DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and Abca6

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	XP_006247716.1	Gene:	Abca6 / 303639	RGDID:	1308998	Length:	1630	Species:	Rattus norvegicus

Alignment Length:	1877	Identity:	379/1877 - (20%)
Similarity:	718/1877 - (38%)	Gaps:	485/1877 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVWKNFQKQKHNKLVLILSLVLPVMSSLFL-LFIRSSSDSNMRDYSIRAEAELLEFSWSSLIGK 74
            :|:.||..|:...|...:|...:||:..|:: ||.....::.:.:...:....:.||:.||
  Rat    18 VLLHKNLLKKWRMKRESLLEWSIPVVIGLYMGLFSYFKENNQVPEVPPQDLGSIDEFNGSS---- 78

  Fly    75 IQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDFENCNDMRI 139
                                   |.|.:.|.||.. :::|...:...:|...:||...:..|:
  Rat    79 -----------------------IMVVYTPISNVT-QQIMNKTITAPTMKGTRIVGVPSEKDL-- 117

  Fly   140 HAASEHYLASVCFRNVDES-LNGLPTVLNFAIIMPSELRNYEDTWIGDSWKETTTLM-DRDVAEE 202
                            ||. |:.:|..  |.|:       :.||:.   :|....|| .....:|
  Rat   118 ----------------DEMLLDHVPRA--FGIV-------FNDTFF---YKLKVYLMYGNPFLKE 154

  Fly   203 DEFDE--DGY-------TDYMGEGFVPLQYHISMQFLRATASK--VEKLPKVVMRRFNENPNVLL 256
            |....  |.|       |.|...|||.||..|:...:..|...  :|:|..|  ..||......:
  Rat   155 DLLAHCWDTYPHVFCSLTRYWKRGFVALQTAINAAIIEVTTKHPVMEELMSV--NAFNMKTLPFI 217

  Fly   257 SEGI--GTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAW---------F 310
            |:.|  ....:|..||.|...:...:..:.:||:..:.:| |::....:....:|         .
  Rat   218 SKDIFQYEIFILFCLLYFSSFIYFASRSVTKERKHSKEFM-KVMGLQDSAFWLSWGLIYVGFIFI 281

  Fly   311 FNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRRSRVA 375
            |:||...:|||..|.::              ..:.::......||.||.::..||...::::.:.
  Rat   282 FSVFIAVIITSTRIIVM--------------TGFLVIFTLFFLYGLSVIAVTFLMAVLLQKAIIT 332

  Fly   376 ---MVMAPIIWILLALPLLSKKELLSDGPDVFYGFATVL-LCN-VSFSRGLSKIFYIEDYTLGVT 435
               :.:..:.|..:...:| .|||.|       ....|| :|: .:|:.|::||.::|....||
  Rat   333 NLFVFLFNLFWGCVGFTVL-HKELPS-------SLEWVLSICSPFAFTSGMTKIIFLEYNLNGV- 388

  Fly   436 IGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLAIRVKNLLK----------- 489
                :|...|...   :|.|..|::         :.|:...|..||:....:|.
  Rat   389 ----VFPDPSGES---YVMIAVFFI---------LAFDGLLYLVLALYFDKILPCGADRRAAPLF 437

  Fly   490 --------KYHATRSAVGRLKRQI-PEVS----FSKTSAE----ALIEFRGVWQKY---SNSTYV 534
                    :...:|:.|  .:|.| ||:.    |.....|    ..|..|.:.::|   |.....
  Rat   438 FLNPVSCFRKRTSRNKV--TERDIDPELPSDEYFEPVDPEYQGKEAIRIRNIRKEYKGKSGKVEA 500

  Fly   535 VQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPK--LGEIYLSGFNIVTQRKEALKNSSIS 597
            ::.:..:||..::.|:|||..:|||:::.:|.|.:.|.  |..:|....:.:...||..|...:.
  Rat   501 LKGLFFDVYESQITAVLGHGGAGKSSLLNILNGLSVPTSGLATVYNKNLSEMQDLKEIRKMIGVC 565

  Fly   598 MSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFL 662
            ..:...|..|.|.::|...:.::|:.......|.:.:|..|.::..:..|...|:.||:|.|.|.
  Rat   566 PQHNVQFDALTVKENLTLFANIKGIVPQSVAQEVQQILSELDMQTIQDELAEHLSEGQKRKLTFG 630

  Fly   663 CAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKL 727
            .|..|..:|::||:|..|:|.......:..:.:::.:|.|.|::.....|..:|||..:||.|.|
  Rat   631 VAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERRADRVILFSTQFTDEADILADRKVILSNGAL 695

  Fly   728 QAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYHTEL 792
            :..|:...|.|.....|.|.:|.||.|..:.:.:|:...||..::            |.|...:|
  Rat   696 KCTGSSVFLKRKWGLGYHLSLFMNETCDSEQLTSFINHHIPGAKL------------KAKTKEKL 748

  Fly   793 INL--IENLARLK---NDLNVYS------FEIHECSIDDILASLYTRDKSTLEF-------GQPG 839
            :..  :|..::..   :||:.||      :|:...:::::..:|.....:|.:|       ....
  Rat   749 VYTLPLEKTSKFPEFFSDLDKYSGQGLMNYEVSMSTLNEVFMNLEGEPSTTQDFEKGETLTDSDS 813

  Fly   840 LQTLLASRQQSAKRRFIIPTMYL-------LEELRQLLIADTRN---WFLPILKLTLPSLVVV-- 892
            |..:..:....:|.:..:..|.|       :..||.|.:...|.   .|||:|.::|..|:..
  Rat   814 LNEMEVAPPSLSKAQKTMSAMSLWRMQVCAIARLRVLKLRRERKAFLTFLPLLGISLIPLITEYM 878

  Fly   893 ----------WTLSMPYFWHNCRQPGHITFPMSDHGDGIILMQKDTLDSELLVASEMYAKVGVTE 947
                      |......::   ..||.:  |..             |.:.|||       :..||
  Rat   879 ANALIEVKTNWEFKTDLYF---LSPGQL--PQG-------------LRTSLLV-------INNTE 918

  Fly   948 VDKTVDITTFIYNYEYKNSLLSDADIME------------AVIFSNVQIEVLF----NTKWPHTA 996
                .:|..|:.:.:::|.:| :.|..|            |:|.|..|.:..|    |||..|..
  Rat   919 ----SNIEDFVQSLKHQNIVL-EVDDFENRNATESLSYNGAIIVSGRQKDYRFSAVCNTKRLHCF 978

  Fly   997 PDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIP 1061
            | .|...:::..:..::....|::|.:||....:        :..:.::.|| ||..|......|
  Rat   979 P-ILMNVISNGILRMLNHTQHIRLEEDVLSSGIV--------VVWFGILEAS-LSILFIVCSVSP 1033

  Fly  1062 LLHMTLSRD------------GRYNY----------VELIAG--------MPTIVLIVAFLIYEL 1096
            .:.|:...|            |.|..          :.|::|        :.|..|:..:|..|:
  Rat  1034 HIAMSSISDFKKKADSQLWISGLYPSAYWCGQALVDITLLSGILLTGYITLYTTKLMHIYLTGEI 1098

  Fly  1097 L--VVLLALFPINIAVIFFHWDLLM-----DSNIHIYSVYVMFIIAACVFSLNILITIM------ 1148
            :  :|||| |....:::|..:.:..     ..|..::|:        |.|   |:||||
  Rat  1099 VLSIVLLA-FGCAASLVFLTYVISFVFGKKRKNSGLWSI--------CFF---IVITIMFDTVLM 1151

  Fly  1149 -PISDMPFVYLKVLL-AYSLGILVYI----AVKELRPFTNPN---TAHFLLLDFHPFYALLHNLM 1204
             |.::...:...:|: ::||..|:.:    |.:..|.|....   :...|||...|::   |.|:
  Rat  1152 DPFNEALLISAMMLVPSFSLNALLIVLEMRAYQYYREFGESKYGLSGVDLLLCLIPYF---HTLL 1213

  Fly  1205 RIASISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIF-IF 1268
            .|                                       :.||.|...|...||....:| |.
  Rat  1214 FI---------------------------------------FVLRCLELKYGKNVVRKDPLFRIA 1239

  Fly  1269 LKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVE 1333
            .:|..|:..|.:|.   |.|.|.:.::     |..|:..:|       |:..|:..|.:..||.|
  Rat  1240 PQSLHVQPNPEEPV---DEDEDVQAER-----MRTSDALST-------VNLDEKPAIIASCLHKE 1289

  Fly  1334 HLSVFFG----------LKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIIS 1388
                :.|          .|.|:::|.|.||:.:::.:.|..|.|||..|:.|.||..|::|.:
  Rat  1290 ----YTGQKKWCCSKRRKKIAVRNISFCVNKGEILGLLGPEGAGKSSSLRMIAGIMKPTAGEV-- 1348

  Fly  1389 SKTVPFKSKDLDS--CHM--------VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEAT 1443
                  :.|:|.|  .|.        :||..||.....::|:.|..::...::..::.......:
  Rat  1349 ------ELKELSSAVAHQGEGHGAAKLGYCPQENVLWPILTVKEHLEVYAAVKGLRKKDAVIAIS 1407

  Fly  1444 KLCKIFGLYKYRFNSLSICSQ----GVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHII 1504
            :|...|.|:    :.|::.::    |:.::|...::::.::.:::||:|.|.||:..::.|...|
  Rat  1408 RLVNAFKLH----DQLNVQARNLVVGLTRKLCFALSILGNSPVLILDEPSTGLDVSGKQQMWQAI 1468

  Fly  1505 H-DLRRRGHSIIYTCSDTAYSTPALRMATLSYPG-IAVIGEREEMQQNYYSSYYMVETRIHLAEL 1567
            . .::.....::.:..|.|.:......|.:...| :.:||..:.:::. :...|::|.|:
  Rat  1469 QAAVKDNKKGVLLSTHDLAEAEALCDRAAIMVSGRLRLIGSIQHLKRR-FGKDYILELRV----- 1527

  Fly  1568 GSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVS 1632
                      .|..::.       |.||.                      |..:||.|..::..
  Rat  1528 ----------KEISQEP-------LVHKE----------------------ILRLFPQAARQDRC 1553

  Fly  1633 FPRVCFWLS-SHMYPMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSIHRQKSNKD 1686
            |..:.:.|. :.::|:|:....|...|:.|.  .:|:||.:::.|||.:.:::...|
  Rat  1554 FSLLTYKLPVTDVHPLSQAFHKLEAVKRGFNLDDYSLSQCTLDRVFLELSKEQELGD 1610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	111/512 (22%)
		ABC_subfamily_A	519..737	CDD:213230	56/222 (25%)
		P-loop_NTPase	1330..1517	CDD:422963	45/211 (21%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468	98/484 (20%)
		ABC2_membrane_4	220..409	CDD:289500	44/228 (19%)
		CcmA	480..795	CDD:224054	77/326 (24%)
		ABC_subfamily_A	482..705	CDD:213230	56/222 (25%)
		ABC2_membrane_3	859..1171	CDD:289468	70/363 (19%)
		ABC2_membrane_4	1007..1178	CDD:289500	36/191 (19%)
		CcmA	1279..1605	CDD:224054	76/386 (20%)
		ABC_subfamily_A	1300..1514	CDD:213230	47/225 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850