DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and Abca8a

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_001268753.1	Gene:	Abca8a / 303638	RGDID:	1307333	Length:	1615	Species:	Rattus norvegicus

Alignment Length:	1636	Identity:	328/1636 - (20%)
Similarity:	623/1636 - (38%)	Gaps:	381/1636 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 GFVPLQYHISMQFLRATA--SKVEKLPKVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVT-I 278
            |||.||..|:...:..|.  |.:|::..:. .::.:..:.:..||..|...|.:.:....|:| .
  Rat   176 GFVALQAAINSAIIEVTTNHSVMEEMMSLT-GKYIKIDSFIAQEGTTTDYFLFLCIIAFSPLTYY 239

  Fly   279 LTTLIVEERELGQRYMLKILNASATLQMAAW--FFNVFTHFLITSLLITILLKIEWNGATAAVNK 341
            ::..:..||:..:.:| .::....:....:|  .:.|.. |::|..|..::..:::...|.
  Rat   240 ISAGVTRERKKMKAFM-TVMGLRDSAFWLSWGLLYGVIV-FIVTLFLTFVVYSVQFVFMTG---- 298

  Fly   342 CPWPILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFY- 405
              :.::......||.|:.||..||:                       :|.||..|:| ..||:
  Rat   299 --FMMIFSLFFFYGLSLISLSFLMS-----------------------VLLKKSFLTD-LVVFFL 337

  Fly   406 -------GFATV-------------LLCNVSFSRGLSKIFYIEDYTL----------GVTIGK-- 438
                   |||.:             ||...:|..|::::..: ||.|          .|.|..
  Rat   338 TVSCGSLGFAALYRYLPVSLEWLLSLLSPFAFMLGMTQLLRL-DYDLESSGHPTGNPNVVIATVF 401

  Fly   439 YMFYRVSKSDFGIFVPIVCFYVQTI----FCTLLAMIFENNAYFWLAIRVKNLLKKYHATRSAVG 499
            .:|:.      |:|..::.||.:.:    :......:|...:.||..        :..|.|:.:.
  Rat   402 LLFFD------GVFYLMLTFYFEKVLPGEYGRRHPPLFFLKSSFWTG--------QNPADRTVLD 452

  Fly   500 RLK-RQIPEVSFSKTSAE----ALIEFRGVWQKY---SNSTYVVQDITLNVYAGEVVALLGHNAS 556
            ..: .:.|:.||...|.:    .:|..|.:.::|   |..|..::|:||:||.|::.|:|||:.:
  Rat   453 NERDYEFPDDSFEPVSTDFHGKEVIRIRNLTKEYIQRSKRTEALKDLTLDVYKGQITAILGHSGA 517

  Fly   557 GKSTIIKMLYGRTRPKLG--EIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRL 619
            ||||::.:|.|...|..|  .|:.:..:.:|..:...|.:.:.......|..|.|.::|...:::
  Rat   518 GKSTLLNVLSGLCVPTKGWVTIHDNKLSEMTDLESISKLTGVCPQCNVQFDFLTVRENLRLFAKI 582

  Fly   620 RGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQ 684
            :|:.  |...|.:.:|..|::::.:.|||.:|:.||:|.|.|..|..|..||.:||:|..|:|..
  Rat   583 KGIQ--EVDNEVQRVLLALEMKNIQNTLVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPF 645

  Fly   685 RTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF 749
            .....::|:.::|.:|.:.|::.....|..:|||...:|:|||:..|:...|.:.....|.|.:.
  Rat   646 SRHRVWNLLKERKADRVVLFSTQFMDEADILADRKVFISQGKLRCAGSSLFLKKKWGIGYHLSLQ 710

  Fly   750 GNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYHTELINLIENLARLKNDLNVYSFEIH 814
            .:|.|..:.:.:.:...||:.::.:......::::..:...:..:|..:|.|.. ||.:.::.:.
  Rat   711 LSETCVHERITSLVKQHIPDSKLSAESEGKLNYILPLERTNKFPDLYRDLERCP-DLGIENYGVS 774

  Fly   815 ECSIDDILASLYTRDKSTLEFGQPGLQTLLASRQQSAKR----RFIIPTMYLLEELR-------- 867
            ..::.::...|  ..||.::......:.:.|...:...|    :|:    .||.|:.
  Rat   775 VTTLTEVFLKL--EGKSAIDSDIGETEDVQAGGTRGPGRLDGEQFV----SLLNEMSKTKGGMAL 833

  Fly   868 --QLLIADTRNWFLPILKLTLPSLVVV--------------------------WTLS-MPYFWHN 903
              |.|.|.||..||. ||....|:|::                          |.|| ..||...
  Rat   834 WWQQLCAVTRLRFLK-LKYRRKSIVILILILGIGLLHILSANVHRLVNQSDYCWELSPHTYFLTP 897

  Fly   904 CRQPGHITFPMSDHGDGIILMQKDTLDSELLVASEMYAKVGVTEVDKTVD-ITTFIYNYEYKNSL 967
            .::|   ..|:::                ||:            ::||.: |..|:::.|.:|..
  Rat   898 GQRP---QMPLTN----------------LLI------------INKTGEKIDDFLHSLEQQNIA 931

  Fly   968 L-----------SDADIMEAVIFS----NVQIEVLFNTKWPHTAP---DSLAQALNSLAVAFIDG 1014
            |           .|:....|:|.:    |....:..|||..:..|   |.::.||..|....:.
  Rat   932 LEVDAFGTRNGTEDSQYNGAIIVAGGEKNYNFTLACNTKRLNCFPVLVDIVSNALLGLFTPSVH- 995

  Fly  1015 DAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSI------PLLHMTLSRD--G 1071
               |:.:....|..|.:|...||               .:.|.|.:      |.:.||...|  .
  Rat   996 ---IQTDRSSFPEDTGYTQFYHL---------------LYMFSWILLMACVPPYISMTSIDDYKN 1042

  Fly  1072 RYNYVELIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAA 1136
            |..:...|:|:..........::|:        |:..|:|.              |||:.|..:|
  Rat  1043 RAQFQLWISGLSPSAYWFGHALFEI--------PVYSALIL--------------SVYIAFYFSA 1085

  Fly  1137 CVFSLNILITIMPISDMPFVYLKVLLA--YSLGILVYIAV-----KELRPFTNPNTAHFLLLDFH 1194
            ...|   :||...:      ::::|.|  |::.::..:.|     ::.|..:...:..|.::.|.
  Rat  1086 PPES---MITTRDL------FIQILYAGGYAMSVIFMMYVISFICRKGRKNSGIWSLCFYIVSFI 1141

  Fly  1195 PFYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLV 1259
            ....:|........:...|.|.....:...::...|.:..|..      ..|..||...::.|..
  Rat  1142 SLCLMLFKFFEDTFLFSSIALIPVVTLVGCTLLHFQNHEFPEI------SLYPERYYTYLFFLAP 1200

  Fly  1260 VVWISIFIFL-----------------------KSHMVKRRPRQPKYFWDSDPDSKYDQNILHIM 1301
            .....||:|:                       :|..|...|.:|:   ..|.|...::    :.
  Rat  1201 FFHFLIFLFILRCLERKFGMKTMRMDPVFRISSRSDRVFNNPEEPE---GEDEDVSLER----VR 1258

  Fly  1302 EPSELENTWIHEKSRV--STLERNHIESKALHVEHLSVFFGLKA----AIKHIDFMVNRYQVMSV 1360
            ..:.|.:....||..:  |.|.:.:...|..        |.||.    |.::|...|.:.:|:.:
  Rat  1259 TANALTSADFQEKPVIIASCLRKEYKGKKKC--------FVLKGKKKIATRNISLCVRKGEVVGL 1315

  Fly  1361 FGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKSKDL-DSCHMVGYSAQEFQTMQLMTILETW 1424
            .|.||.|||..:|.|.|...||:|:      |..|.... |:...:||..||....|.||:.|..
  Rat  1316 LGHNGAGKSTSIKMITGEIKPSAGQ------VQLKGNSTGDTPEFLGYCPQENALWQHMTVREHL 1374

  Fly  1425 DLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPF 1489
            ::...|:...:........:|.....|.....:.:...|:||.::|...::::.:..::|||:|.
  Rat  1375 EIFAAIKGMSKSDAAVAIARLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPS 1439

  Fly  1490 THLDIVSQRSMLHIIHDL---RRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIGEREEM 1547
            |.:|...|:.|...|...   ..||..:     .|.|...|.    |:|.:....:..||..:.:
  Rat  1440 TGMDPEGQQQMWQAIQATFANTERGALL-----TTHYMAEAEAVCDRVAIMVSGKLRCIGSIQHL 1499

  Fly  1548 QQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKY 1612
            :.. :...|::|.::                        .|.|.:...:.|....|..:|.:.:|
  Rat  1500 KSK-FGKEYLLEMKV------------------------KTPTQVEPLNMEIMRLFPQAARQERY 1539

  Fly  1613 LKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQ--DFYSFSVSQPSVNSVF 1675
            ..|.     |:        ..||      ..:.|:|:....|...||  |...:|:||.::..||
  Rat  1540 SSLM-----VY--------KLPR------EDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVF 1585

  Fly  1676 LSIHRQKSNKD 1686
            |.:.:::...|
  Rat  1586 LELSKEQELDD 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	117/515 (23%)
		ABC_subfamily_A	519..737	CDD:213230	66/222 (30%)
		P-loop_NTPase	1330..1517	CDD:422963	48/194 (25%)
Abca8a	NP_001268753.1	ABC2_membrane_3	27..416	CDD:289468	53/279 (19%)
		DUF4149	267..354	CDD:290390	23/117 (20%)
		ABC_subfamily_A	477..698	CDD:213230	66/222 (30%)
		drrA	493..787	CDD:130256	75/298 (25%)
		ABC2_membrane_3	<1005..1155	CDD:289468	33/195 (17%)
		CcmA	1272..1591	CDD:224054	82/381 (22%)
		ABC_subfamily_A	1279..1500	CDD:213230	57/239 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850