Protein Alignment CG43672 and Abca7

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_997481.1
• Gene: Abca7 / 299609
• RGDID: 1303134
• Length: 2170
• Species: Rattus norvegicus
• Alignment Length: 1944
• Identity: 371/1944 - (19%)
• Similarity: 669/1944 - (34%)
• Gaps: 570/1944 - (29%)

  Fly   110 LRRLMGDALGKLSM-------SEDKIVD--FENCNDMRIHA-----ASEHYLASVCFRNVDESLN 160
            |..::|..|..:|:       ||:.:|.  .|...:.|:.|     :.||.|        |.|..
  Rat   393 LAEILGQILECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPL--------DSSEP 449

  Fly   161 GLPTVLNFAIIMPSELR-----NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTD--YMGEGF 218
            ..||...     |..||     :.:|.        |.|...||...:.....|...|  |:..||
  Rat   450 PSPTTTG-----PGHLRVKIRMDIDDV--------TRTNKIRDKFWDPGPSADPLMDLRYVWGGF 501

  Fly   219 VPLQYHISMQFLRATASK-------VEKLP------KVVMRRFNENPNVLLSEGIGTSVVLLILL 270
            |.||..:....:|..:.:       ::::|      .|.:|        :||.    |:.|.:.|
  Rat   502 VYLQDLLEQAAVRVLSGRDSRAGLYLQQMPHPCYVDDVFLR--------VLSR----SLPLFLTL 554

  Fly   271 GFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGA 335
            .:::.|.:....:|.|:|...|..::.:..|..:....||.:....||:::.|:.::||:.
  Rat   555 AWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG---- 615

  Fly   336 TAAVNKCPWP---ILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKK 394
                |..|:.   ::..||.::..:..:...|:::...|:.:|.....:.:..|.||   .::.:
  Rat   616 ----NILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWR 676

  Fly   395 ELLSDGPDVFYGFATV-LLCNVSFSRGLSKIFYIED-------YTLGVTIGKYMFYRVSKSDF-- 449
            |.|..|     |...| ||..|:|..|...:..:|:       :.||....:.:|.....|.|
  Rat   677 ERLPLG-----GLLAVSLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLL 736

  Fly   450 --GIFVPIVCFYVQTIFCTLLAMI-----FENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPE 507
              .:...:..:|::.: |.....|     |.....:|..         ....:|:|.....|.|:
  Rat   737 LDAVIYGLALWYLEAV-CPGQYGIPEPWNFPFRRSYWCG---------PGPPKSSVLAPAPQDPK 791

  Fly   508 VSFSKTSAEAL--IEFRGVWQKYSNSTY-VVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRT 569
            |...:.....:  :..||:.:.:..|.. .::.:.|:.|.|.:.|.||||.:||:|.:.:|.|..
  Rat   792 VLVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLF 856

  Fly   570 RPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKAL 634
            .|..|...:.|.::.|.......:..|...|..||..|.|.:|:.|..||:|:|......|.:.|
  Rat   857 PPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAIDSEQEHL 921

  Fly   635 LRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKN 699
            :|.:.|.....|....|:.|.:|.|....||.||:::||:|:|..|:|.......:.|:|..::.
  Rat   922 IRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREG 986

  Fly   700 RSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF--------------- 749
            |::..::::...|..:.||:.:::.|.|...|:...|.|.|...|.|.:.
  Rat   987 RTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDLKGDT 1051

  Fly   750 ---------GNEKCSFKDVYA----FMATFIPEIEMDSILADCASFLVKHKYHTELINLIENL-- 799
                     |:|..:...|..    ..::.:|..:...:....|..|...:.|.....|:|.|
  Rat  1052 EDPRREKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALILELVQRHVPGAQLVEELPH 1116

  Fly   800 ------------------------ARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQPGL 840
                                    .:|:. |.:..:.|.:.::::|...:.....:..|.|.|..
  Rat  1117 ELVLALPYAGALDGSFATVFQELDQQLER-LGLTGYGISDTNLEEIFLKVVEEAHAHGEGGDPRQ 1180

  Fly   841 QT-LLASRQQSAKRRFIIPTMYLLE--ELRQLLI------------ADTRNWFLP---------- 880
            |. ||.:..|....    |...:||  ||.:|::            |..:.|.|.
  Rat  1181 QQHLLTATPQPHTG----PEASVLENGELAKLVLDPQAPKGSAPTTAQVQGWTLTCQQLRALLHK 1241

  Fly   881 ------------ILKLTLPSLVV----VWTLSMP------------------------------- 898
                        ..::.||:|.|    .:||.:|
  Rat  1242 RFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPADPN 1306

  Fly   899 -----------------------------------YF-----------------WH--------N 903
                                               ||                 |.        .
  Rat  1307 RMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASILASGNWTPDSPSPACQ 1371

  Fly   904 CRQPGHITF-------------PMSDHGDGIILMQ------KDTLDSEL--LVASEMYAKVGVTE 947
            |.|||....             |.:..|.|.::..      .|.|....  ||...:..|..|.|
  Rat  1372 CSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDE 1436

  Fly   948 V-----------------------------------DKTVD-----ITTFIYNYEYKNSLLSDAD 972
            |                                   ..|:|     :|.:....:.:|||
  Rat  1437 VRYGGFSLGGRDPDLPSGREVVRTVAEMRALLSPQPGNTLDRILNNLTQWALGLDARNSL----- 1496

  Fly   973 IMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHL 1037
                        ::.||.|..|.....:.:|.|.|..||:...:       |....:|.||...|
  Rat  1497 ------------KIWFNNKGWHAMVAFVNRANNGLLRAFLPSGS-------VRHAHSITTLNHPL 1542

  Fly  1038 NI------------DGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMP-TIVLIV 1089
            |:            ...|::.:.|:.|...|:.:...|.:...|..|..:::|::|:| |:..:.
  Rat  1543 NLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLG 1607

  Fly  1090 AFLIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNIL-----ITIMP 1149
            .||                      ||:            ..:::|.|:..|..|     ..:.|
  Rat  1608 NFL----------------------WDM------------CNYLVAVCIVVLIFLAFQQKAYVAP 1638

  Fly  1150 ISDMPFVYLKVLL-AYSLGILVYIAVKELRP----FTNPNTAHFLLLDFHPFYALL--------- 1200
             .::|.:.|.:|| .:|:..|:|       |    |:.|:||:.:|...:.|..:.
  Rat  1639 -ENLPALLLLLLLYGWSITPLMY-------PASFFFSVPSTAYVVLTCINLFIGINSSMATFVLE 1695

  Fly  1201 ----HNLMRIASISEKIWL-----CSDRQIYE---TSVYADQCNTIPNCCDDDAQEFYHLRYLCC 1253
                .||..::.|.::::|     |..|.:.:   ....||....:     .|.|....||:...
  Rat  1696 LLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERL-----GDKQFQSPLRWDII 1755

  Fly  1254 VYLLLVVVWISIFIFLKSHMVKRRPR---QPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKS 1315
            ...||.:|.......|.:.:::.|.|   |||... ..|..:.|:::             :.|:.
  Rat  1756 GKNLLAMVAQGPLFLLITLLLQHRNRLLPQPKSRL-PPPLGEEDEDV-------------VRERE 1806

  Fly  1316 RVSTLERNHIESKALHVEHLS-VFFGLKA-AIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGI 1378
            ||:   :...:...|.:..|: |:.|.:: |:.|:...:...:...:.|.||.||:...:.:.|.
  Rat  1807 RVT---KGATQGDVLVLRDLTKVYRGQRSPAVDHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGD 1868

  Fly  1379 YTPSSGR-IISSKTVPFKSKDLDSCH-MVGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAE 1441
            ..||||. :::...|   :::..:.| .:||..|......|:|..|..:|..|:|...:......
  Rat  1869 TLPSSGEAVLAGHNV---AQEPSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQT 1930

  Fly  1442 ATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHD 1506
            |.......||..|........|.|..::|:..:||:.|..::.||:|.|.:|..::|.:.:.:..
  Rat  1931 ALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNNLLS 1995

  Fly  1507 LRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGS 1569
            :.|.|.|::.| |.:.....||  |:|.:.......:|..:.::..:.:.        |...|..
  Rat  1996 VVREGRSVVLT-SHSMEECEALCTRLAIMVNGRFRCLGSAQHLKSRFGAG--------HTLTLRV 2051

  Fly  1570 PIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFP 1634
            |.|                       ..|.:.||               |...||.|.::.|...
  Rat  2052 PPD-----------------------QPEPAIAF---------------IVTTFPDAELREVHGS 2078

  Fly  1635 RVCFWLSSHMYP-----MSRIVDTL--HRNKQDFYSFSVSQPSVNSVFLSIHRQKSNKD 1686
            |:.|.|.    |     ::|:...|  .........|||||.::..|||...:.:..::
  Rat  2079 RLRFQLP----PGGGCTLARVFRELAAQGKAHGVEDFSVSQTTLEEVFLYFSKDQGEEE 2133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	110/491 (22%)
		ABC_subfamily_A	519..737	CDD:213230	60/218 (28%)
		P-loop_NTPase	1330..1517	CDD:422963	46/190 (24%)
Abca7	NP_997481.1	rim_protein	1..2127	CDD:130324	371/1936 (19%)
		ABC2_membrane	<557..742	CDD:304374	39/197 (20%)
		ABC_subfamily_A	805..1024	CDD:213230	60/218 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1044..1086		4/41 (10%)
		ABC_subfamily_A	1818..2038	CDD:213230	53/223 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2129..2170		0/5 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010