Protein Alignment CG43672 and Abca3

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_038883.2
• Gene: Abca3 / 27410
• MGIID: 1351617
• Length: 1704
• Species: Mus musculus
• Alignment Length: 1896
• Identity: 392/1896 - (20%)
• Similarity: 717/1896 - (37%)
• Gaps: 433/1896 - (22%)

  Fly    11 LLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIR----SSSDSNMRDYSIRAEAEL-LEFSWSS 70
            ||:|||:..:|...||.:|.|.||::.|..|:::|    |.:..|...|..::..|| |.||:..
Mouse     9 LLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATVYPDQSIQELPLFFSFPP 73

  Fly    71 LIGKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDFENCN 135
            ..|..:                       :|:.|:.:.|.|.:. :.:.:..|.:.::..|.:..
Mouse    74 PGGTWE-----------------------LAYVPSHSDAARTIT-ETVKREFMIKMRVHGFSSEK 114

  Fly   136 D----MRIHAASEHYLASVCF-RNVDESLNGLPTVLNFAIIMPSELRNYEDTWIG-------DSW 188
            |    :|....|...||:|.| .:.:.|.:.||..:.:.:......|||..|..|       :.|
Mouse   115 DFEDYIRYDNHSSSVLAAVVFEHSFNHSQDPLPLAVKYHLRFSYTRRNYMWTQTGNIFLKETEGW 179

  Fly   189 KETT--TLMDRDVAEEDEFDEDGYTDYMGEGFVPLQYHISMQFLR--ATASKVEKLPK--VVMRR 247
            ..|:  .|.......|....:.|...|:.|||:.:|:.:....:|  |..|..:...|  |:.:|
Mouse   180 HTTSLFPLFPSPGPREPSSPDGGEPGYIREGFLAMQHAVDKAIMRYHANTSAQQLFQKLMVITKR 244

  Fly   248 FNENPNV----LLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAA 308
            |...|.:    |::  |...:.||::|.|.:....:...:|:|:|...:..::::..::.|..:|
Mouse   245 FPFPPYISDPFLIA--IQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLNSWLHWSA 307

  Fly   309 WFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRRSR 373
            ||...|..|||....:|:|..::.....|.::.....::|.||:.:..|..|...::::...::.
Mouse   308 WFLMFFLFFLIVVSFMTLLFCVKVKKDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKAN 372

  Fly   374 VAMVMAPIIWILLALP-----------LLSKKELLSDGPDVFYGFATVLLCNVSFSRG------- 420
            :|..:...::.....|           .||:| |||           .||.||:.:.|
Mouse   373 IAAAVGGFLYFFTYTPYFFVAPRYNWMTLSQK-LLS-----------CLLSNVAMAMGAQLIGKF 425

  Fly   421 ------------LSKIFYIEDYTLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFE 473
                        |:.:...:::..|..:|..:.      |..:: .:|.:||:.:|.....:  .
Mouse   426 EAKGTGIQWRDLLNPVNVDDNFCFGQVLGMLLL------DSALY-GLVTWYVEAVFPGQFGV--P 481

  Fly   474 NNAYFWLAIRVKNLLKKYHA--TRSAVGRLKR-QIPEVSFSKTSAEALIE--FRGVWQKYSNSTY 533
            ...:|:       |:..|..  .|:.||:.:. ..||.:......||..|  ..|:..|:.:..:
Mouse   482 QPWHFF-------LMPSYWCGNPRTVVGKEEEGSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVF 539

  Fly   534 VV--------QDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEA 590
            .|        :|:|||:|.|::..|||||.:||:|.:.:|.|...|..|..|:.|:.|.....:.
Mouse   540 QVGNKDKMGIRDLTLNLYEGQITVLLGHNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMAQI 604

  Fly   591 LKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQ 655
            .|:..:...:..||..|.|.:||.|.::|:|||..:...|.|.:|..|.|||........|:.|.
Mouse   605 RKSLGLCPQHDVLFDNLTVAEHLYFYAQLKGLSLQKCPEEVKQMLHILSLEDKRDLRSKFLSGGM 669

  Fly   656 RRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIF 720
            :|.|....|...|:::::||:|..|:|.......:.|:..||.:|::..|::....|..:.|||.
Mouse   670 KRKLSIGIALIAGSKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIA 734

  Fly   721 VLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVK 785
            :|:||:||..|:...|.:.....|.:.:.....|:.:.:...:...:|...::|......||::.
Mouse   735 ILAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFILP 799

  Fly   786 HKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQ-----PGLQTL-L 844
            .:......:|...|.:.:.:|.:.||.          ||:.|.::..|..|:     ..:|.: |
Mouse   800 KESTHRFESLFAKLEKKQKELGIASFG----------ASVTTMEEVFLRVGKLVDTSMDIQAIQL 854

  Fly   845 ASRQQSAKRR------------FIIPTM---YLLEELRQLLIADT-------------------- 874
            .:.|...:||            .:.||.   .|:||...|:..:|
Mouse   855 PALQYQHERRASDWALDSNLCGVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFWAMFLKKAAYS 919

  Fly   875 -RNW-------FLPILKLTLPSLVVVWTLSM---PYFWHNCRQPGHITFPMSDHGDGIILMQ--- 925
             |.|       .:|:..|||..|.:.:|..:   |....:..:.|....|.|..|...:..|
Mouse   920 WREWKMVAAQVLVPLTCLTLALLAIHYTSEIFDDPLLKLSLNEYGRTVVPFSVPGTSRLAQQLSE 984

  Fly   926 --KDTLDSELLVASEMYAKVGVTEVDKTVDITTF-IYNYEYKNSLLSDADIMEAVIFSN----VQ 983
              :|.|.:|.....|:..           |:..| ::....:....::..:: |..|.:    ..
Mouse   985 NLRDMLQAERQEPREVLG-----------DLEEFLVFRASVEGGGFNERCLV-ATSFKDRGELTV 1037

  Fly   984 IEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLN--IDGYDLIF 1046
            :..|||.:..|:...:||...|.|........|.|::.....|.:|:...:.|.|  ..|:|:
Mouse  1038 VTALFNNQAYHSPATALAIVDNLLFKLLCGPQASIEISNYPQPRNTLQVAKDHFNEGRKGFDI-- 1100

  Fly  1047 ASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAG-------------------MPTIVLIVAFL 1092
            |..|.....|:.|...:.....|..:..:|:.::|                   :|:::|:|.|.
Mouse  1101 ALNLLIAMAFLASTFSILAVSERAVQAKHVQFVSGVHVATFWFSALLWDLISFLVPSLLLLVVFQ 1165

  Fly  1093 IYEL-----------LVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILIT 1146
            .:.:           |::||.|:...|..:.:.......:....|:...:|.|.:.:.:. |::|
Mouse  1166 AFNVHAFTRDGHMADLLLLLMLYGWAIIPLMYLMSFFFSAASTAYTRLTIFNILSGIATF-IMVT 1229

  Fly  1147 IMPISDMPFVYLKVLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPFYALLHNLMRIASISE 1211
            ||.|..:....|...|.:...:|             ||  |.|.:....||
Mouse  1230 IMRIPAVKLEELSRTLDHVFLVL-------------PN--HCLGMAVSNFY-------------- 1265

  Fly  1212 KIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMVKR 1276
                    :.|||..|........:.|     :.|:::|
Mouse  1266 --------ENYETRRYCTSSELAAHYC-----KKYNIQY-------------------------- 1291

  Fly  1277 RPRQPKYFWDSDPDSKY------------------DQNILHIMEP-----------SELENTW-- 1310
              ::..|.|.:....|:                  :.|:|..:..           :||:|..
Mouse  1292 --QESFYAWSTPGVGKFVTSMAASGGIYLTLLFLIETNLLWRLRTFICAFRRRWTLAELQNRTSV 1354

  Fly  1311 -------IHEKSRVSTLERNHIESKALHVEHLSVFFGLKA---AIKHIDFMVNRYQVMSVFGANG 1365
                   ..|:||:.....:.:....|.:..||..:..:|   |:..|...|.:.:...:.|.||
Mouse  1355 LPEDQDVAEERSRILVPSLDSMLDTPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNG 1419

  Fly  1366 TGKSVLLKTILGIYTPSSG-RIISSKTVPFKSKDLDSCHM-VGYSAQEFQTMQLMTILETWDLIL 1428
            .||:...|.:.|..|.:|| ..:...::   |.|:..... :||..|....:..||..|...:..
Mouse  1420 AGKTTTFKMLTGEETITSGDAFVGGYSI---SSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYA 1481

  Fly  1429 RIR-------------RSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDA 1480
            |:|             ..:.:.....|.||.|.:             |.|..::||.||||:.:.
Mouse  1482 RLRGIPERLINACVENTLRGLLLEPHANKLVKTY-------------SGGNKRKLSTGIALIGEP 1533

  Fly  1481 ELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGE 1543
            .:|.||:|.|.:|.|::|.:...:...|..|.:|:.| |.:.....||  |:|.:.......:|.
Mouse  1534 AVIFLDEPSTGMDPVARRLLWDTVARARESGKAIVIT-SHSMEECEALCTRLAIMVQGQFKCLGS 1597

  Fly  1544 REEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSAD 1608
            .:.::..:.|.|                     |.:||....|....|     :||.|
Mouse  1598 PQHLKSKFGSGY---------------------SLQAKVRSEGKQDAL-----EEFKA------- 1629

  Fly  1609 RWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDF--YSFSVSQPSV 1671
                     .::..||.:|:::.....|.:.|.......:::...|.:.|:.:  ..:||||.|:
Mouse  1630 ---------FVDLTFPGSILEDEHQDMVHYHLPGCDLSWAKVFGILEKAKEKYGVDDYSVSQISL 1685

  Fly  1672 NSVFLSI-HRQ 1681
            ..||||. |.|
Mouse  1686 EQVFLSFAHLQ 1696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	123/508 (24%)
		ABC_subfamily_A	519..737	CDD:213230	70/227 (31%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	50/204 (25%)
Abca3	NP_038883.2	rim_protein	1..>43	CDD:130324	14/33 (42%)
		rim_protein	<206..1699	CDD:130324	342/1675 (20%)