Protein Alignment CG43672 and Abca7

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_001334010.1
• Gene: Abca7 / 27403
• MGIID: 1351646
• Length: 2167
• Species: Mus musculus
• Alignment Length: 2045
• Identity: 390/2045 - (19%)
• Similarity: 719/2045 - (35%)
• Gaps: 553/2045 - (27%)

  Fly     7 HVFCLLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSL 71
            |....|:|:..:.       |||..:|....:.|...:.:..:....:.::..:...|   |..|
Mouse   274 HPVSRLLWRRLKP-------LILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHEL---WGVL 328

  Fly    72 ----------------------IGKIQERRAKMASKQRNFTTNVFIPDIRVAFA-PNSNAALRRL 113
                                  :|...:|:....::::......|:...|..:: ..::|.:.||
Mouse   329 GPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGRL 393

  Fly   114 MGDALGKL--SMSEDKI--VDFENCNDMR-IHAASEHYL-ASVCFRNVDESLNGLPTVLNFAIIM 172
            .| .||::  .:|.||:  |..|.....| :....|..| |.:.|.:.:..|:  |:.|:...:.
Mouse   394 AG-ILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLD--PSELSSPALS 455

  Fly   173 PSELR-----NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTD--YMGEGFVPLQYHISMQFL 230
            |..||     :.:|.        |.|...||...:.....|.:.|  |:..|||.||..:....:
Mouse   456 PGHLRFKIRMDIDDV--------TRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQAAV 512

  Fly   231 RA-------TASKVEKLP------KVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTILTTL 282
            |.       |...::::|      .|.:|        :||.    |:.|.:.|.:::.|.:....
Mouse   513 RVLGGGNSRTGLYLQQMPHPCYVDDVFLR--------VLSR----SLPLFLTLAWIYSVALTVKA 565

  Fly   283 IVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWP-- 345
            :|.|:|...|..::.:..|..:....||.:....||:::.|:.::||:.        |..|:.
Mouse   566 VVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG--------NILPYSHP 622

  Fly   346 -ILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDGPDVFYG 406
             ::..||.::..:..:...|:::...|:.:|.....:.:..|.||   .::.:|.|..|     |
Mouse   623 VVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLG-----G 682

  Fly   407 -FATVLLCNVSFSRGLSKIFYIED-------YTLGVTIGKYMFYRVSKSDF----GIFVPIVCFY 459
             .|..||..|:|..|...:..:|:       :.||....:.:|.....|.|    .:...:..:|
Mouse   683 LLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWY 747

  Fly   460 VQTIFCTLLAMI-----FENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAEAL- 518
            ::.: |.....|     |.....:|..         ....:|:|.....|.|:|...:.....:
Mouse   748 LEAV-CPGQYGIPEPWNFPFRRSYWCG---------PGPPKSSVLAPAPQDPKVLVEEPPLGLVP 802

  Fly   519 -IEFRGVWQKYSNSTY-VVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGF 581
             :..||:.:.:..... .:|.:.|:.|.|.:.|.||||.:||:|.:.:|.|...|..|...:.|.
Mouse   803 GVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGH 867

  Fly   582 NIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKT 646
            ::.|.......:..|...|..||..|.|.:|:.|..||:|:|......|.:.|:|.:.|.....|
Mouse   868 DVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLKRDT 932

  Fly   647 LVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKV 711
            ....|:.|.:|.|....||.||:::||:|:|..|:|.......:.|:|..::.|::..::::...
Mouse   933 QTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDE 997

  Fly   712 ASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF-------------------------GN 751
            |..:.||:.:::.|.|...|:...|.|.|...|.|.:.                         ||
Mouse   998 AELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGN 1062

  Fly   752 EKCS---FKDVYAFMATFIPEIEMDSILADCASFLVKHKYHTELINLIENL-------------- 799
            .:.|   |....:..:...|......|....|..|...:.|.....|:|:|
Mouse  1063 GRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGAL 1127

  Fly   800 ----ARLKNDLN-------VYSFEIHECSIDDIL---------------ASLYTR---------- 828
                |.:..:|:       :..:.|.:.::::|.               ..|:.|
Mouse  1128 DGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGP 1192

  Fly   829 DKSTLEFGQ---------------PG-------------LQTLLASRQQSAKR-------RFIIP 858
            :.|.||.|:               |.             |:.||..|...|:|       :.::|
Mouse  1193 EASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLP 1257

  Fly   859 TMYLLEELRQLLIADTRNWFLPI------------------------LKL--------------- 884
            .:::...|...||......:.|:                        :||
Mouse  1258 ALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEPSM 1322

  Fly   885 ------------------TLP-------SLVVV--WTLSMPYFWHNCRQPGHITF---------- 912
                              |:|       |::..  ||...|.....|.|||....
Mouse  1323 QDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAGAGG 1387

  Fly   913 ---PMSDHGDGIILMQ------KDTLDSEL--LVASEMYAKVGVTEV--------DKTVDITTFI 958
               |.:..|.|.::..      .|.|....  ||...:..|..|.||        .:..|:.|
Mouse  1388 PPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPT-- 1450

  Fly   959 YNYEYKNSLLSDADIMEAV----------IFSNV-----------QIEVLFNTKWPHTAPDSLAQ 1002
             .:|...:|   |:|...:          |.:|:           .:::.||.|..|.....:.:
Mouse  1451 -GHEVVRTL---AEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNR 1511

  Fly  1003 ALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNI------------DGYDLIFASCLSFCFC 1055
            |.|.|..|.:...       .|....:|.||...||:            ...|::.:.|:.|...
Mouse  1512 ANNGLLHALLPSG-------PVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMS 1569

  Fly  1056 FIWSIPLLHMTLSRDGRYNYVELIAGMP-TIVLIVAFLIYELLVVLLALFPINIAVIFFHWDLLM 1119
            |:.:...|.:...|..|..:::|::|:| |:..:..||                      ||:
Mouse  1570 FVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFL----------------------WDM-- 1610

  Fly  1120 DSNIHIYSVYVMFIIAACVFSLNIL-----ITIMPISDMPFVYLKVLL-AYSLGILVYIAVKELR 1178
                      ..:::|.|:.....|     ..:.| .::|.:.|.:|| .:|:..|:|
Mouse  1611 ----------CNYLVAVCIVVFIFLAFQQRAYVAP-ENLPALLLLLLLYGWSITPLMY------- 1657

  Fly  1179 P----FTNPNTAHFLLLDFHPFYALL-------------HNLMRIASISEKIWL-----CSDRQI 1221
            |    |:.|:||:.:|...:.|..:.             .||..::.|.::::|     |..|.:
Mouse  1658 PASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGL 1722

  Fly  1222 YE---TSVYADQCNTIPNCCDDDAQEFYHLRY-LCCVYLLLVVVWISIFIFLKSHMVKRRPRQPK 1282
            .:   ....||....:     .|.|....||: :....||.::....:|:.:...:..|....|:
Mouse  1723 IDMVRNQAMADAFERL-----GDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQ 1782

  Fly  1283 YFWDSDPDSKYDQNILHIMEP-SELENTWIHEKSRVSTLERNHIESKALHVEHLS-VFFGLK-AA 1344
                |.|         .::.| .|.:.....|:.||:   :...:...|.:..|: |:.|.: .|
Mouse  1783 ----SKP---------RLLPPLGEEDEDVAQERERVT---KGATQGDVLVLRDLTKVYRGQRNPA 1831

  Fly  1345 IKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGR-IISSKTVPFKSKDLDSCH-MVGY 1407
            :..:...:...:...:.|.||.||:...:.:.|...||||. :::...|   :::..:.| .:||
Mouse  1832 VDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNV---AQERSAAHRSMGY 1893

  Fly  1408 SAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSL 1472
            ..|......|:|..|..:|..|:|...:......|.......||..|........|.|..::|:.
Mouse  1894 CPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLAT 1958

  Fly  1473 GIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSY 1535
            .:||:.|..::.||:|.|.:|..::|.:.:.:..:.|.|.|::.| |.:.....||  |:|.:..
Mouse  1959 ALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLT-SHSMEECEALCTRLAIMVN 2022

  Fly  1536 PGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFS 1600
            .....:|..:.::..:.:.        |...|..|.|                       ..|.:
Mouse  2023 GRFRCLGSSQHLKGRFGAG--------HTLTLRVPPD-----------------------QPEPA 2056

  Fly  1601 AAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFYS-- 1663
            .||               |...||.|.::.|...|:.|.|.    |..|.  ||.|..::..:
Mouse  2057 IAF---------------IRITFPGAELREVHGSRLRFQLP----PGGRC--TLTRVFRELAAQG 2100

  Fly  1664 -------FSVSQPSVNSVFLSIHRQKSNKD 1686
                   |||||.::..|||...:.:..::
Mouse  2101 RAHGVEDFSVSQTTLEEVFLYFSKDQGEEE 2130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	110/491 (22%)
		ABC_subfamily_A	519..737	CDD:213230	60/218 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	45/190 (24%)
Abca7	NP_001334010.1	rim_protein	1..2128	CDD:130324	390/2041 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1088		5/45 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1172..1192		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2126..2167		0/5 (0%)