Protein Alignment CG43672 and Abca7

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_001334010.1
• Gene: Abca7 / 27403
• MGIID: 1351646
• Length: 2167
• Species: Mus musculus
• Alignment Length: 2048
• Identity: 394/2048 - (19%)
• Similarity: 722/2048 - (35%)
• Gaps: 559/2048 - (27%)

  Fly     7 HVFCLLVWK----------------NFQK-------QKHNKLVLILSL--VLPVMSSLFLLFIRS 46
            |....|:|:                ||.:       |...:|.|:..|  :..|:......|:..
Mouse   274 HPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMND 338

  Fly    47 SSDSNMRDYSIRAEAELLEFSWSSLIGKIQERRAKMASKQRNFTTNVFIPDIRVAFA-PNSNAAL 110
            |::..|..       .||:      :|...:|:....::::......|:...|..:: ..::|.:
Mouse   339 STNVAMLQ-------RLLD------VGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADM 390

  Fly   111 RRLMGDALGKL--SMSEDKI--VDFENCNDMR-IHAASEHYL-ASVCFRNVDESLNGLPTVLNFA 169
            .||.| .||::  .:|.||:  |..|.....| :....|..| |.:.|.:.:..|:  |:.|:..
Mouse   391 GRLAG-ILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLD--PSELSSP 452

  Fly   170 IIMPSELR-----NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTD--YMGEGFVPLQYHISM 227
            .:.|..||     :.:|.        |.|...||...:.....|.:.|  |:..|||.||..:..
Mouse   453 ALSPGHLRFKIRMDIDDV--------TRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQ 509

  Fly   228 QFLRA-------TASKVEKLP------KVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTIL 279
            ..:|.       |...::::|      .|.:|        :||.    |:.|.:.|.:::.|.:.
Mouse   510 AAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLR--------VLSR----SLPLFLTLAWIYSVALT 562

  Fly   280 TTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPW 344
            ...:|.|:|...|..::.:..|..:....||.:....||:::.|:.::||:.        |..|:
Mouse   563 VKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG--------NILPY 619

  Fly   345 P---ILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDGPDV 403
            .   ::..||.::..:..:...|:::...|:.:|.....:.:..|.||   .::.:|.|..|
Mouse   620 SHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLG--- 681

  Fly   404 FYG-FATVLLCNVSFSRGLSKIFYIED-------YTLGVTIGKYMFYRVSKSDF----GIFVPIV 456
              | .|..||..|:|..|...:..:|:       :.||....:.:|.....|.|    .:...:.
Mouse   682 --GLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLA 744

  Fly   457 CFYVQTIFCTLLAMI-----FENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAE 516
            .:|::.: |.....|     |.....:|..         ....:|:|.....|.|:|...:....
Mouse   745 LWYLEAV-CPGQYGIPEPWNFPFRRSYWCG---------PGPPKSSVLAPAPQDPKVLVEEPPLG 799

  Fly   517 AL--IEFRGVWQKYSNSTY-VVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYL 578
            .:  :..||:.:.:..... .:|.:.|:.|.|.:.|.||||.:||:|.:.:|.|...|..|...:
Mouse   800 LVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASI 864

  Fly   579 SGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDW 643
            .|.::.|.......:..|...|..||..|.|.:|:.|..||:|:|......|.:.|:|.:.|...
Mouse   865 LGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLK 929

  Fly   644 EKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNN 708
            ..|....|:.|.:|.|....||.||:::||:|:|..|:|.......:.|:|..::.|::..::::
Mouse   930 RDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHH 994

  Fly   709 QKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF------------------------ 749
            ...|..:.||:.:::.|.|...|:...|.|.|...|.|.:.
Mouse   995 LDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKS 1059

  Fly   750 -GNEKCS---FKDVYAFMATFIPEIEMDSILADCASFLVKHKYHTELINLIENL----------- 799
             ||.:.|   |....:..:...|......|....|..|...:.|.....|:|:|
Mouse  1060 DGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYA 1124

  Fly   800 -------ARLKNDLN-------VYSFEIHECSIDDIL---------------ASLYTR------- 828
                   |.:..:|:       :..:.|.:.::::|.               ..|:.|
Mouse  1125 GALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPP 1189

  Fly   829 ---DKSTLEFGQ---------------PG-------------LQTLLASRQQSAKR-------RF 855
               :.|.||.|:               |.             |:.||..|...|:|       :.
Mouse  1190 TGPEASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQV 1254

  Fly   856 IIPTMYLLEELRQLLIADTRNWFLPI------------------------LKL------------ 884
            ::|.:::...|...||......:.|:                        :||
Mouse  1255 VLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQE 1319

  Fly   885 ---------------------TLP-------SLVVV--WTLSMPYFWHNCRQPGHITF------- 912
                                 |:|       |::..  ||...|.....|.|||....
Mouse  1320 PSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAG 1384

  Fly   913 ------PMSDHGDGIILMQ------KDTLDSEL--LVASEMYAKVGVTEV--------DKTVDIT 955
                  |.:..|.|.::..      .|.|....  ||...:..|..|.||        .:..|:.
Mouse  1385 AGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLP 1449

  Fly   956 TFIYNYEYKNSLLSDADIMEAV----------IFSNV-----------QIEVLFNTKWPHTAPDS 999
            |   .:|...:|   |:|...:          |.:|:           .:::.||.|..|.....
Mouse  1450 T---GHEVVRTL---AEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAF 1508

  Fly  1000 LAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNI------------DGYDLIFASCLSF 1052
            :.:|.|.|..|.:...       .|....:|.||...||:            ...|::.:.|:.|
Mouse  1509 VNRANNGLLHALLPSG-------PVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVF 1566

  Fly  1053 CFCFIWSIPLLHMTLSRDGRYNYVELIAGMP-TIVLIVAFLIYELLVVLLALFPINIAVIFFHWD 1116
            ...|:.:...|.:...|..|..:::|::|:| |:..:..||                      ||
Mouse  1567 AMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFL----------------------WD 1609

  Fly  1117 LLMDSNIHIYSVYVMFIIAACVFSLNIL-----ITIMPISDMPFVYLKVLL-AYSLGILVYIAVK 1175
            :            ..:::|.|:.....|     ..:.| .::|.:.|.:|| .:|:..|:|
Mouse  1610 M------------CNYLVAVCIVVFIFLAFQQRAYVAP-ENLPALLLLLLLYGWSITPLMY---- 1657

  Fly  1176 ELRP----FTNPNTAHFLLLDFHPFYALL-------------HNLMRIASISEKIWL-----CSD 1218
               |    |:.|:||:.:|...:.|..:.             .||..::.|.::::|     |..
Mouse  1658 ---PASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLG 1719

  Fly  1219 RQIYE---TSVYADQCNTIPNCCDDDAQEFYHLRY-LCCVYLLLVVVWISIFIFLKSHMVKRRPR 1279
            |.:.:   ....||....:     .|.|....||: :....||.::....:|:.:...:..|...
Mouse  1720 RGLIDMVRNQAMADAFERL-----GDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRL 1779

  Fly  1280 QPKYFWDSDPDSKYDQNILHIMEP-SELENTWIHEKSRVSTLERNHIESKALHVEHLS-VFFGLK 1342
            .|:    |.|         .::.| .|.:.....|:.||:   :...:...|.:..|: |:.|.:
Mouse  1780 LPQ----SKP---------RLLPPLGEEDEDVAQERERVT---KGATQGDVLVLRDLTKVYRGQR 1828

  Fly  1343 -AAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGR-IISSKTVPFKSKDLDSCH-M 1404
             .|:..:...:...:...:.|.||.||:...:.:.|...||||. :::...|   :::..:.| .
Mouse  1829 NPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNV---AQERSAAHRS 1890

  Fly  1405 VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKR 1469
            :||..|......|:|..|..:|..|:|...:......|.......||..|........|.|..::
Mouse  1891 MGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRK 1955

  Fly  1470 LSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMAT 1532
            |:..:||:.|..::.||:|.|.:|..::|.:.:.:..:.|.|.|::.| |.:.....||  |:|.
Mouse  1956 LATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLT-SHSMEECEALCTRLAI 2019

  Fly  1533 LSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQ 1597
            :.......:|..:.::..:.:.        |...|..|.|                       ..
Mouse  2020 MVNGRFRCLGSSQHLKGRFGAG--------HTLTLRVPPD-----------------------QP 2053

  Fly  1598 EFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY 1662
            |.:.||               |...||.|.::.|...|:.|.|.    |..|.  ||.|..::..
Mouse  2054 EPAIAF---------------IRITFPGAELREVHGSRLRFQLP----PGGRC--TLTRVFRELA 2097

  Fly  1663 S---------FSVSQPSVNSVFLSIHRQKSNKD 1686
            :         |||||.::..|||...:.:..::
Mouse  2098 AQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEE 2130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	110/491 (22%)
		ABC_subfamily_A	519..737	CDD:213230	60/218 (28%)
		P-loop_NTPase	1330..1517	CDD:422963	45/190 (24%)
Abca7	NP_001334010.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1088		5/45 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1172..1192		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2126..2167		0/5 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010