Protein Alignment CG43672 and Abca13

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_839990.2
• Gene: Abca13 / 268379
• MGIID: 2388707
• Length: 5034
• Species: Mus musculus
• Alignment Length: 1974
• Identity: 391/1974 - (19%)
• Similarity: 698/1974 - (35%)
• Gaps: 505/1974 - (25%)

  Fly     9 FCL-------------LVWKNFQKQKHNKLVL------ILSLV------------LPVMSSLFL- 41
            |||             |||...:...|.|::.      |..::            :.|:|..||
Mouse  3257 FCLKLYQEILQSPNGALVWSFLKPVLHGKILYTPNSPEINEVIQKANYTFYFVDKIKVLSETFLK 3321

  Fly    42 ---LFIRSSSDSNM--------RDYSIRAEAE-LLEFSWSSLIGKIQERRAKMASKQRNFTTNVF 94
               || :.|.:..|        |:..||...| .|......|...:| ...:|..|..|
Mouse  3322 ISKLF-QGSGNGQMFNQLQDALRNKFIRNFVESQLHIDMDKLTEDLQ-TYGRMLDKMFN------ 3378

  Fly    95 IPDIRVAFAPNSNAALRRLMGDALGKLS----MSEDKIVDFENCNDMRIHAASEH--YLASVCF- 152
                      :..|...|.:|..|..||    :...:.|:..:..:.:.|...:.  :|||:.|
Mouse  3379 ----------HVEAGHFRFLGGMLANLSSCVVLDRFQAVETVDTLETKAHELMQQNSFLASIIFN 3433

  Fly   153 -----RNVDESLNGLPTVLNFAIIMPSELRNYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYT- 211
                 |::..:.:.||..:.:.|..........|.....|||          .........|:.
Mouse  3434 SSLRHRHIRSAPHKLPPHVTYTIRTNVLYSMRTDMIKNPSWK----------FHPQNLPAGGFKY 3488

  Fly   212 DYMGEGFVPLQYHISMQFLRATASKVEKLPKVVMRRFNENP---NVLLSEGIGTSVVLLILLGFM 273
            :|:   |||||..|....:.....: |.|......:....|   :.|....:|....|:::|.:|
Mouse  3489 NYI---FVPLQDMIERAIIVVQTGQ-ESLEPTTQAQAAPYPCHTSDLFLNNVGFFFPLIMMLTWM 3549

  Fly   274 FPVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAA 338
            ..|..:...:|.|||:.....::::....|:...:||........::|..:.::||:  :|....
Mouse  3550 VAVASMVRKLVYEREIQIEEYMRMMGLHPTIHFLSWFLENMATLALSSAALAVILKM--SGIFMH 3612

  Fly   339 VNKCPWPILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDG 400
            .:..   |:..:|:.:|.|...:...::....::..|.:...:.:::..||   ||.....||
Mouse  3613 SDAF---IIFLYLLDFGVSAVMMSYFLSVFFNQANTAALCTSLGYMISFLPYVVLLVLHNQLS-- 3672

  Fly   401 PDVFYGFA-TVLLCNVS---FSRGLSKIFYIEDYTLGVT-------------------------- 435
                  || ..|||.:|   |.:|:..|.::|....|:.
Mouse  3673 ------FAIQTLLCLLSTTAFGQGVFFITFLEGQEEGIQWGNMYRAPEPGGMTFGWVCWMILFDA 3731

  Fly   436 ----IGKYMFYRVSKSDFGI----FVPIVCFYVQTIF-------CTLLAMIFENNAYFWLAIRVK 485
                :|.:.|..:....||:    :.|....|.::|.       |:|.:.:|..|..|.
Mouse  3732 ILYFLGGWYFSNLVPGTFGLGKPWYFPFTASYWKSICGLMERRRCSLSSGLFFFNEDFG------ 3790

  Fly   486 NLLKKYHATRSAVGRLKRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVVQDITLNVYAGEVVAL 550
               .|..:.::..|.::...|.|        |||   .|.::|.:....||::||..:..::.||
Mouse  3791 ---NKGLSQQNGPGEMEGGNPGV--------ALI---SVTKEYEDHKVAVQELTLTFHRDQITAL 3841

  Fly   551 LGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVF 615
            ||.|.:||:|||.||.|...|..|.|.::|.|:.|...:..:...:......|...|.|.:||:.
Mouse  3842 LGTNGAGKTTIISMLMGLFPPTSGTITINGKNLQTDLSKVREELGVCPQQDVLLDNLTVREHLML 3906

  Fly   616 LSRLRG--LSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPF 678
            .:.::.  .:..|.:.:....|..::|...:......|:.|.:|.|....||.|.::.|:||:|.
Mouse  3907 FASIKAPWWTTKELQQQVNKTLDEVELTQHQHKPAGVLSGGMKRKLSIGIAFMGMSKTVVLDEPS 3971

  Fly   679 DGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNES 743
            .|:|.......:.::|..::.|:|.||:::...|..::|.:.||.:|:|:.:.....|.....:.
Mouse  3972 SGVDPCSRRSLWDILLKYREGRTIIFTTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQG 4036

  Fly   744 YRL-------IIFGNEKCSFKDVYAFMATFIPEIEM-DSILADCASFLVKHKYHTELINLIENLA 800
            ..|       |:...|......|.:.:..:||:..: ||...:....:.|....|....|.:.|.
Mouse  4037 LTLTLSKQPSILETQEPKDVARVTSLIQIYIPQAFLKDSCGGELTYTIPKDADRTCFKGLCQALD 4101

  Fly   801 RLKNDLNVYSFEIHECSIDDILASLY--TRDKSTL------------EFG--QPGLQTLLASRQQ 849
            :....|::..:.|.:.:::::...|.  |..||.:            ..|  .|...:.|::..:
Mouse  4102 QNLQHLHLTGYGISDTTLEEVFLMLLQDTNKKSYITPDNKVEPQNERPVGPLSPHNVSPLSTPPE 4166

  Fly   850 SAKRRFIIPTMYLLEE----LRQLLIADTRNWFLPILKLTLPSLVVVWTLSMPYFWHNCRQPGHI 910
            .|....|.....||.:    ||:.|:...|.|......|.||.|.|  .|:|..|   ..||..|
Mouse  4167 GALPEPIGGCQLLLGQAVALLRKRLLHTLRAWKSTTSDLLLPVLFV--ALAMGLF---MVQPLAI 4226

  Fly   911 TFP------------------MSDHGDGI--ILMQK---------------------------DT 928
            |:|                  ..:||..:  :|::|                           ::
Mouse  4227 TYPPLKLTPGHYETAETYFFSSGNHGPDLTHVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPES 4291

  Fly   929 LDS--------ELLVASEMYAKVGVTEVDKT-VDITTFIY---------NYEYKNSLLSDA-DIM 974
            .||        :...|..:...:|.|.::.: .|:..::.         .:.:...:.:|| |:.
Mouse  4292 QDSCGCLKCPNKSAGAPSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVK 4356

  Fly   975 EAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAV-------------------------AFIDG 1014
            ..........:|.:|.|..|:.| |....||:|.:                         |.::.
Mouse  4357 TNTSKPRTLAKVWYNQKGFHSLP-SYLNHLNNLILWHHLPANAVDWRQYGITLYSHPYGGALLNE 4420

  Fly  1015 D--------AGIKVELEVLPFSTIHT----------------LQLHLNIDG----------YDLI 1045
            |        .|:.:.: ||.||.:..                || |::..|          ||::
Mouse  4421 DRILESIRQCGVALCI-VLGFSILSASIGSSVVRDRVTGAKRLQ-HISGLGHRTYWLINFLYDML 4483

  Fly  1046 FASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELL---VVLLALFPIN 1107
            | ..:|.|.|                    |.:|....    :.||...|.|   .:|||||  .
Mouse  4484 F-YLVSVCLC--------------------VAVIGAFQ----LTAFTFRENLAATALLLALF--G 4521

  Fly  1108 IAVIFFHWDLLMDSNIHIYS----VYVMFIIAACVFSL-NILITIMPISDMPFVYLKVLLAYSLG 1167
            .|:|  .|..||.   .|:|    .::.:|....:|.| .:|:|.||          .|||
Mouse  4522 YAMI--PWMYLMS---RIFSSSDVAFISYISLNFIFGLCTMLMTTMP----------RLLA---- 4567

  Fly  1168 ILVYIAVKELRPFTNPNTAHFLLLDFHPFYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCN 1232
              :....:.|:...|.....|.:.   |.:.|...|         |.||.::..|:.:
Mouse  4568 --IISKAQNLQKIYNVLKWAFTIF---PQFCLGQGL---------IELCYNQIKYDLT------- 4611

  Fly  1233 TIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMVK----RRPRQPKYFWDSDPDSKY 1293
              .|...|.....:.:.:|..:::.|.:.  ..|:.|...|:.    |.||
Mouse  4612 --HNFGIDSYVSPFEMNFLGWIFVELTLQ--GTFLLLLRLMLHGDLLRWPR-------------- 4658

  Fly  1294 DQNILH-IMEPSELENTWIHEKSRVSTLERNHIESKA---------LHVEHLSVFFGLKAAIKHI 1348
            |.::|. |::|:        :...|.|.:...:|.:.         |...:.|||.|...|:..|
Mouse  4659 DHSVLQDIVKPA--------KDIDVETEQMRVLEGRTGGDMMVLCNLSKSYRSVFGGKTTAVHGI 4715

  Fly  1349 DFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKSKDLDSCH----MVGYSA 1409
            ...:.|.:...:.|.||.|||...|.:.|...||||..: .:|......||.|..    ::||..
Mouse  4716 SLGIPRGECFGLLGVNGAGKSTTFKILNGETPPSSGYTV-IRTPQGDMVDLASAGKAGILIGYCP 4779

  Fly  1410 QEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGI 1474
            |:....:|:|..|......|:|...:......|..|.:...|..:....::..|.|..::||..:
Mouse  4780 QQDALDELLTGWEHLQYYCRLRGIPKQYIPEVAADLVRRLHLESHVDKPVATYSGGTRRKLSTAL 4844

  Fly  1475 ALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPG 1537
            ||:...:::|||:|.:.:|..|:|.:...|....|.|.:.:.| |.:.....||  |:|.:....
Mouse  4845 ALVGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRDGCAAVLT-SHSMEECEALCTRLAIMVDGS 4908

  Fly  1538 IAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAA 1602
            ...:|..:.::..:...|                                |..:..||.....:|
Mouse  4909 FRCLGPPQHIKNRFGDGY--------------------------------TVKVWLHKEGSQPSA 4941

  Fly  1603 FTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQ--DFYSFS 1665
            .:|.      |||      .||....|......:.:.:......::.:...|..||.  :...:|
Mouse  4942 VSDC------LKL------HFPGIQFKGQRLNLLEYHVQKSWECLADLFKVLENNKSLLNIEHYS 4994

  Fly  1666 VSQPSVNSVFLSIHRQKSNKDAFP 1689
            :||.::..||::...::.....||
Mouse  4995 ISQTTLEQVFVNFATEQLQTPCFP 5018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	113/515 (22%)
		ABC_subfamily_A	519..737	CDD:213230	58/219 (26%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	51/190 (27%)
Abca13	NP_839990.2	rim_protein	1..>82	CDD:130324
		rim_protein	3036..5019	CDD:130324	391/1974 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4135..4165		3/29 (10%)