Protein Alignment CG43672 and ABCA4

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_000341.2
• Gene: ABCA4 / 24
• HGNCID: 34
• Length: 2273
• Species: Homo sapiens
• Alignment Length: 2116
• Identity: 405/2116 - (19%)
• Similarity: 708/2116 - (33%)
• Gaps: 675/2116 - (31%)

  Fly    61 AELLEFSW------SSLIGKIQERRAKMASKQRNFTT--NVFIPDI------------------- 98
            :.:|.|:|      .:.:|....|:..:.|..|..|:  |..|..:
Human   332 SRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMG 396

  Fly    99 RVAFAPNSNAALRRLMGDALGKLSMSED--KIVD------------FENCNDMRIHAASEHYLAS 149
            ::.:.|:|.|| ||::.:|.......|.  |:|.            |:|...|
Human   397 KILYTPDSPAA-RRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQM------------ 448

  Fly   150 VCFRNVDESLNGLPTV------------------LNFAIIMPSELRNYEDTWIGDSWKETTTLMD 196
                |:.....|.|||                  |||....|.|  :..|......|::...:.|
Human   449 ----NMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRE--SQADDMANFDWRDIFNITD 507

  Fly   197 RDVAEEDEFDE----DGYTDYMGE------------------GFV-PLQY--------HISMQFL 230
            |.:...:::.|    |.:..|..|                  |.| |..|        |:..: :
Human   508 RTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWTSSLPPHVKYK-I 571

  Fly   231 RATASKVEKLPKVVMRRFNENPNV------------------LLSEGIGTSVV------------ 265
            |.....|||..|:..|.::..|..                  ::.:||..|.|
Human   572 RMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQ 636

  Fly   266 --------------------LLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWF 310
                                :.::|.:::.|::....||.|:||..:..||....|..:....||
Human   637 MPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWF 701

  Fly   311 FNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRRSRVA 375
            .:.|:...::..|:||.:   .:|.....:. |: ||..||:::..:...|..|:::...::.:|
Human   702 LDSFSIMSMSIFLLTIFI---MHGRILHYSD-PF-ILFLFLLAFSTATIMLCFLLSTFFSKASLA 761

  Fly   376 MVMAPIIWILLALPLL--------SKKELLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTL 432
            ...:.:|:..|.||.:        ...||..         |..||..|:|..|...:...|:..|
Human   762 AACSGVIYFTLYLPHILCFAWQDRMTAELKK---------AVSLLSPVAFGFGTEYLVRFEEQGL 817

  Fly   433 GV---------TIGKYMFYRVSKS----DFGIFVPIVCFYVQTIF----CTLLAMIFENNAYFWL 480
            |:         |.|....:.:|..    |..:: .::.:|:..:|    .|.|...|.....:||
Human   818 GLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVY-GLLAWYLDQVFPGDYGTPLPWYFLLQESYWL 881

  Fly   481 ----------------------------------------------AIRVKNLLKKYH-ATRSAV 498
                                                          .:.||||:|.:. ..|.||
Human   882 GGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAV 946

  Fly   499 GRLKRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIK 563
            .||                            |.|:         |..::.|.||||.:||:|.:.
Human   947 DRL----------------------------NITF---------YENQITAFLGHNGAGKTTTLS 974

  Fly   564 MLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAK 628
            :|.|...|..|.:.:.|.:|.|......::..:...:..||..|.|.:|::|.::|:|.|:.||:
Human   975 ILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQ 1039

  Fly   629 LEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLI 693
            ||.:|:|....|.........||:.|.:|.|....||.|..::||||:|..|:|.......:.|:
Human  1040 LEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL 1104

  Fly   694 LDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGT--VKKLC-----------RMLN-ESY 744
            |..:..|:|..::::...|..:.|||.::::|:|...||  ..|.|           :|.| :|.
Human  1105 LKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQ 1169

  Fly   745 RLIIFGNEKCSFK---------------------DVYAFMAT---FIPEIEMDSILADCASFLVK 785
            |....|...||.|                     ||...|..   .:||.::...:.....||:.
Human  1170 RKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLP 1234

  Fly   786 HK--YHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEF------------- 835
            :|  .|....:|...|.....||.:.||.|.:..:::|...: |.|..:...
Human  1235 NKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKV-TEDSDSGPLFAGGAQQKRENVN 1298

  Fly   836 --------------------------------GQP-------------GLQTLLASRQQSAKRRF 855
                                            |||             |.|.:|...|....:||
Human  1299 PRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRF 1363

  Fly   856 IIPTMYLLEELRQLLIADTRNWFLPILKLTLP--------------------------------S 888
            ........:.|.|:::..|..:...:|.:.:|                                :
Human  1364 QHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFT 1428

  Fly   889 LVVVWTLSMPYFWHNCRQPG--------------------HIT---------------------- 911
            ::....|:.|.|.:.|.:.|                    :||
Human  1429 VLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTR 1493

  Fly   912 -----FPMSDHGDGII-----------LMQ-------------------KDTLDSELLVASEMYA 941
                 .|....|.|.:           ::|                   :.:|.|:..|..:.|.
Human  1494 EKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYG 1558

  Fly   942 KVGVTEVDKTVDITTFIYNYEYKNSLLSDADIMEAV-------------------IFSNVQIEVL 987
            .:.:......|.||.     |.....|||...:..|                   :.:...|:|.
Human  1559 GISIGGKLPVVPITG-----EALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVW 1618

  Fly   988 FNTKWPHTAPDSLAQALNSLAVAFIDGDA-----GIKVELEVLPFSTIHTLQLHLNIDGYDLIFA 1047
            ||.|..|.....|..|.|::..|.:..|.     ||.|..:.|..:.....::.:.....|.:.|
Human  1619 FNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVA 1683

  Fly  1048 SCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGM-PTIVLIVAFLIYELLVVLLALFPINIAVI 1111
            .|:.|...|:.:..:|::...|..:..:::.|:|: ||...:..||
Human  1684 ICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFL------------------- 1729

  Fly  1112 FFHWDLLMDSNIHIYSVYVMFIIAACVF------------SLNILITIMPI---SDMPFVYLKVL 1161
               ||::.      |||....::.  :|            :|..|:.::.:   :.:|.:|....
Human  1730 ---WDIMN------YSVSAGLVVG--IFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASF 1783

  Fly  1162 LAYSLGILVYIAVKELRPF--TNPNTAHFLLLDFHPFYALLHN---LMRIASISEKIWL-----C 1216
            | :.:....|:|:.....|  .|.:...|:|       .|..|   |:|..::..|:.:     |
Human  1784 L-FDVPSTAYVALSCANLFIGINSSAITFIL-------ELFENNRTLLRFNAVLRKLLIVFPHFC 1840

  Fly  1217 SDRQIYE-------TSVYA---DQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKS 1271
            ..|.:.:       |.|||   ::.:..|...|...:..:.:.....||.||.:: :....|| |
Human  1841 LGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLL-VQRHFFL-S 1903

  Fly  1272 HMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLS 1336
            ..:....::|  ..|.|.|         :.|          |:.|:.| ..|..:...|| |...
Human  1904 QWIAEPTKEP--IVDEDDD---------VAE----------ERQRIIT-GGNKTDILRLH-ELTK 1945

  Fly  1337 VFFGLKA-AIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKS--KD 1398
            ::.|..: |:..:...|...:...:.|.||.||:...|.:.|..|.:||    ..||..||  .:
Human  1946 IYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSG----DATVAGKSILTN 2006

  Fly  1399 LDSCHM-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSIC 1462
            :...|. :||..|.....:|:|..|...|..|:|..........|....|..||..|........
Human  2007 ISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTY 2071

  Fly  1463 SQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPA 1527
            |.|..::||..|||:....|:|||:|.|.:|..::|.:.::|..:.|.|.:::.| |.:.....|
Human  2072 SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLT-SHSMEECEA 2135

  Fly  1528 L--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGT 1590
            |  |:|.:.......:|..:.::..:...|      |...::.||          |:|....
Human  2136 LCTRLAIMVKGAFRCMGTIQHLKSKFGDGY------IVTMKIKSP----------KDDLLPD--- 2181

  Fly  1591 LLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTL- 1654
             |....|.|...|..|..|.::..:                    :.|.:||.  .::||...|
Human  2182 -LNPVEQFFQGNFPGSVQRERHYNM--------------------LQFQVSSS--SLARIFQLLL 2223

  Fly  1655 -HRNKQDFYSFSVSQPSVNSVFLSIHRQKSNKDAFP 1689
             |::......:||:|.:::.||::..:|::.....|
Human  2224 SHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLP 2259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	120/537 (22%)
		ABC_subfamily_A	519..737	CDD:213230	62/219 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	53/190 (28%)
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	405/2116 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..911		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1284..1345		3/60 (5%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000269|PubMed:31481235	2244..2249		2/4 (50%)