Protein Alignment CG43672 and Abca16

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_006507746.1
• Gene: Abca16 / 233810
• MGIID: 2388711
• Length: 1679
• Species: Mus musculus
• Alignment Length: 1863
• Identity: 381/1863 - (20%)
• Similarity: 726/1863 - (38%)
• Gaps: 392/1863 - (21%)

  Fly    11 LLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMR-DYSIRAEAELLEFSWSSLIGK 74
            :|:||||..:|...:.....|:..::..:.||..|:.:|.|:. .|...|:.
Mouse    11 VLLWKNFTLKKRQIISTSAELLAALLFVIMLLIFRALTDMNIAGPYHFTAQP------------- 62

  Fly    75 IQERRAKMASKQRNFTTNVFIPDIR---VAFAPNSNAALRRLMGDALGKLSM--------SE--- 125
                .|.|.|         ||.|.:   :.:.|:....:|.::.|....|:.        ||
Mouse    63 ----IAIMPS---------FIKDAQEWELVYIPSEIDVVREIIEDVKRNLNTTIKVRGFPSEAEF 114

  Fly   126 DKIVDFENCNDMRIHAASEHYLASV---C-FRNVDESLNGLPTVLNFAIIMPSELRNYEDTWIGD 186
            ::.:.|:|        .|:..||::   | |:|..:.   ||..:.:.:......|.   .|..|
Mouse   115 EEYILFDN--------MSQKVLAAIVFDCGFKNKSDP---LPLQVKYHLRFVGAQRT---IWWPD 165

  Fly   187 --SWKETTTLMDRDVA---EEDEFDEDGYTDYMGEGFVPLQYHIS---MQFLRATASK--VEKLP 241
              .|| |..|.....:   ....:.:.|...|:.|||:.:|:.:.   |.:..::|.|  .:::.
Mouse   166 KLGWK-TRLLFPNHPSIRPRNPNYLDGGSPGYIKEGFLAVQHALDKSIMLYHESSAGKKLFDEID 229

  Fly   242 KVVMR-RFNENPNVLLSEGIGTSVVLLILLGF-MFPVTILTTLIVEERELGQRYMLKILNASATL 304
            .|:.| .:..:|...|.......:.|:.:|.| ...::|:.:::.|:.:..:.|.| |:.....:
Mouse   230 TVIQRFPYPSHPQDKLLWISSPFIPLMFILMFSSIVLSIMRSIVFEKEKRLKEYQL-IMGLRNWI 293

  Fly   305 QMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPIL--------LCFLISYGCSVTSL 361
            ....:||..|..::|..|||.|||.::      .|.:   |||        ..||..|..:....
Mouse   294 IWIGYFFTFFPLYVIIILLICILLFVQ------IVEE---PILRYSDCSFIFVFLTCYAIASICF 349

  Fly   362 IILMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFATV-------LLCNVSFSR 419
            ..::::...::|:|.....:::.....|.    ..:|:    :||...:       |..||:.:.
Mouse   350 AFMVSTFFSKTRLAASAGNLLFFASFFPY----NFISE----YYGMLNLTTKITACLSANVALAL 406

  Fly   420 GLSKIFYIEDYTLGV---------------TIGKYMFYRVSKSDFGIFV-PIVCFYVQTIF---C 465
            |::.:..:|...:||               ..|    |.:....|..|: .:|.:||:.:|   |
Mouse   407 GINILIKLEIQEIGVKWHNLWTPANLEDNLNFG----YMLGMLLFDAFLYSLVTWYVEAVFPGQC 467

  Fly   466 TLLA--MIFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAEALIEFRGVWQKY 528
            .:..  ..|...:|::...:::...::...|.......:.:.|.:       ||.|....:.:::
Mouse   468 GVPQPWYFFLMRSYWFGKPKIRKTTEEAKCTPIVHNCYEAEPPNL-------EAGIHIMHLHKEF 525

  Fly   529 SNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKN 593
            .|.. .|.:::||:|.|:|..|||||.:||:|.:.:|.||.....||.|::|:||.....|..|:
Mouse   526 KNKP-AVNNLSLNIYEGQVTVLLGHNGAGKTTTLSVLTGRFAATRGEAYINGYNISDNMIEVRKD 589

  Fly   594 SSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRV 658
            ......:..||.:|.:.:||.|...::|:.:.....|...:|....|::...||....:.|.||.
Mouse   590 LGFCPQHDLLFDDLTLSEHLFFYCMVKGIPQNINCEEIDRMLSAFNLQENYHTLSGSASGGVRRK 654

  Fly   659 LQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLS 723
            |..:.|...|:::||||:|..|:|.......:.::...|.||:|..|::....|..:.||:.::.
Mouse   655 LSIVLALMAGSKVVILDEPSSGMDPVSRRATWDILQHYKHNRTILLTTHYMDEADVLGDRVAIMV 719

  Fly   724 KGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKY 788
            :|.|...|:...|.::....|.:::...:.|...::.|.:...:|...:::.:.:..||::..||
Mouse   720 RGTLHCCGSSVFLKQIYGAGYHIVMEKQQYCDVDNIIAMIQQHVPGAVLENNIENELSFILPKKY 784

  Fly   789 HTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQPGLQTL----LASR-- 847
            .:....|...|...:..|.:.||.....:::::...:     :.|...|..:||:    ||.|
Mouse   785 VSRFETLFTELEMRQKALGIASFGASITTMEEVFVKV-----NKLATPQKSIQTIQPYYLAYRKM 844

  Fly   848 QQSAKRRFIIPTMY------LLEEL----------------------RQLLIADTRNWFLPILKL 884
            :|..::...:|..|      .|.|:                      |.|.|  :|||...:|::
Mouse   845 RQDEQQNVNMPINYSKPNFPYLSEIATVKFNTGVPLYRQQFYSLFIKRALFI--SRNWKFMLLQI 907

  Fly   885 TLPSLVVVWTL--------SMPYFWHNCRQPGHITFPMSDHGDG-IILMQKDTLDSELLVASEMY 940
            .:..:|..:.|        .:|....|....|....|.|..|:. :.|.....|:..|...::..
Mouse   908 IVVMVVTTYLLLALHLNNNDIPERELNLSHYGRTIVPYSTSGNSDLALNLTKNLNIFLKSKNQNL 972

  Fly   941 AKVGVTEVD---KTVDITTFIYNYEYKNSLLSDADIMEAVIFSNVQIE-------VLFNTKWPHT 995
            .|:.....|   |..|..||                  .::..::::|       :.||.:..|:
Mouse   973 RKIRGDMNDYILKNKDCHTF------------------CLVALSIKVERNKTVLTIFFNNEAYHS 1019

  Fly   996 APDSLAQALNSLAVAFIDGDAGIKV--ELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIW 1058
            ...||:...|.|.:.....||.|.|  :.:.||    |.....:.::|..::  .||:|....:.
Mouse  1020 PAISLSILDNILFMTLSGPDASITVFNKPQPLP----HYGSNIVPVNGLQIV--QCLAFGISVVV 1078

  Fly  1059 SIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELL------VVLLALFPI-NIAVIFFHWD 1116
            ....:.....|..:..:::.:.|:......::.|:.:|:      .||||:|.. .:.....|::
Mouse  1079 GSFSIQTVTERTSQAKHIQFLTGVCVHTYWLSALLCDLIFFFFACCVLLAIFKFCQLEAFVVHYN 1143

  Fly  1117 LLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFVYLKVLL----AYSLGILVYIAVKEL 1177
            .|  ..|.|:.:|     ..||..|..:.:.: .:.....|:|:.|    :....|::|..::.
Mouse  1144 FL--DTILIFMLY-----GWCVVPLTYIASFL-FNSSTAAYIKITLFNYFSTMFSIIIYTIIQF- 1199

  Fly  1178 RPFTN--PNTAHFL---LLDFHPFYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNC 1237
              :.|  ||..|.|   :|...|.|.|..::.:.....|...||: |:.  .|:|.|       |
Mouse  1200 --YGNDFPNFVHILIRAILMALPSYNLAMSISKYFDDYEVKRLCA-REF--KSIYLD-------C 1252

  Fly  1238 CDDDAQEFYH-------------LRYLCCVYLLLVVVWISIFIFLKSHMVK-------RRPRQPK 1282
            .|...|...:             |..:..|:|||::...|:...|||.:.:       .:.|:.:
Mouse  1253 SDPYTQNNVYGFGEHGIGKFLITLATIGLVFLLLLLSLESVSCSLKSFVFRNIIFYFYNKLRKGR 1317

  Fly  1283 YFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLSVFF--GLKAAI 1345
            ....|:..:|.|       |..:::.    ||.:|.||......:..|..|...::|  .:..|:
Mouse  1318 NAIPSNQRTKED-------EDEDIKK----EKGKVFTLLLRLQNTPLLLNEVTKIYFKCPVVKAV 1371

  Fly  1346 KHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSG-RIISSKTVPFKSKDLDSCHMVGYSA 1409
            |:|..:|.:.:...:.|.||.||:...|.:.|..|.:|| ..|...:|....:.:.|  .:||..
Mouse  1372 KNISLVVKKSECFGLLGLNGAGKTTTFKMLTGEETITSGIAFIDGNSVTRTPRKIRS--RIGYCP 1434

  Fly  1410 QEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNS---------------- 1458
            |....:..||..|:  |::..|                ::|:.:...|.
Mouse  1435 QTESVLNHMTGRES--LVMYAR----------------LWGVLEQDINEYVEAFLHSVHLEPIAD 1481

  Fly  1459 --LSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDT 1521
              :...|.|..:|||..||||..:.::.||:|...:|.|:|..:...|..:.:.|.:||.| |..
Mouse  1482 QFIHTYSAGSKRRLSTAIALMGKSSVVFLDEPSIGMDPVAQHLLWETITWICKTGKAIIIT-SHR 1545

  Fly  1522 AYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDR 1584
            .....||  |:|.:.......:|..:.:::. :...|.:..||::|:              .||
Mouse  1546 MEECEALCTRLAIMVKGRFTCLGTPQHVRKR-FGHVYTLTVRINIAK--------------DED- 1594

  Fly  1585 AGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPR----VCFWLSSHMY 1645
                      |.:||.          .::|:      .||    .|:.|..    :.:::.|...
Mouse  1595 ----------KVEEFK----------NFIKV------TFP----GNIKFQEFHGTIGYYIPSKEI 1629

  Fly  1646 PMSRIVDTLHRNKQDF--YSFSVSQPSVNSVFLSIHRQKSNKD 1686
            ...::...|...|..|  ..:||.:.::..:||:.    :|.|
Mouse  1630 YWGKVFAILEEAKVLFKLEDYSVKRVTLEQIFLTF----ANTD 1668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	115/502 (23%)
		ABC_subfamily_A	519..737	CDD:213230	63/217 (29%)
		P-loop_NTPase	1330..1517	CDD:422963	49/207 (24%)
Abca16	XP_006507746.1	rim_protein	<196..1665	CDD:130324	335/1632 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950