Protein Alignment CG43672 and Abca9

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_671753.2
• Gene: Abca9 / 217262
• MGIID: 2386796
• Length: 1623
• Species: Mus musculus
• Alignment Length: 1901
• Identity: 366/1901 - (19%)
• Similarity: 682/1901 - (35%)
• Gaps: 525/1901 - (27%)

  Fly     4 QICHVFCLLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSW 68
            |:..:.|....:.|:.::...|..:.||:|       :||:...| ||:.......|..:::
Mouse    11 QMWALLCKNWLRKFRMRRETLLEWLFSLLL-------ILFVYQLS-SNLHQVHDAPEMSVVD--- 64

  Fly    69 SSLIGKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDFEN 133
               :|::.           ||..:.::    :.|||.|.|. ..:|........|....||   .
Mouse    65 ---LGRVD-----------NFNDSNYM----MVFAPESEAT-HEIMNKVASAPFMKGRTIV---A 107

  Fly   134 CNDMRIHAASEHYLASVCFRNVDESLNGLPTVLNFAIIMPSELRNYEDTW---IGDSW------- 188
            |.|                   ::|:|.|.  ||::|.....:  ::||:   :..||
Mouse   108 CPD-------------------EKSMNELD--LNYSIDAVRVI--FKDTFSYHLKFSWGQRIPKT 149

  Fly   189 KE-------TTTLMDRDVAEEDEFDEDGYTDYMGEGFVPLQYHISMQFLR--ATASKVEKLPKVV 244
            ||       ...|.::.:.|...|.|        :|||..|..|:...:.  ...|.:|:|..|:
Mouse   150 KEHKDHSAPCEPLNNKMICENSAFWE--------KGFVAFQAAINAGIIEMITNHSVMEELMSVI 206

  Fly   245 MRRFNENPNVLLSEGIGTS-VVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAA 308
            .... :.|..:...|:.|. .:...::.|...:..|:..|.:||:    ||..::......:.|.
Mouse   207 GSNM-KMPPFIAQGGVATDFFIFFCVISFSSLIYYLSVNITQERQ----YMTTLMAMMGLRESAF 266

  Fly   309 W--FFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRR 371
            |  :..::..|:   |::.:|:.:....|...|......:.|.||. ||.|:.:|..||:..:::
Mouse   267 WLSWSLMYAGFI---LVVAVLMSLIVKSAQVVVLTGFMVVFLLFLF-YGLSLITLSFLMSVLIKK 327

  Fly   372 ---SRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFATVLLCNVS---FSRGLSKIFYIEDY 430
               :.:|:.:..:.|..|....|.|.         ...|....||.:|   |:.|::::.:: ||
Mouse   328 PFLTGLAIFILTVFWGSLGFTALYKH---------LPAFVEWTLCFLSPFAFTTGMAQLIHL-DY 382

  Fly   431 TLGVTI------GKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLAIRV-KNLL 488
            .:...:      ..|:                      |..||..::.:...|..||:.. |..|
Mouse   383 DVNSNVNLNSPNNSYL----------------------IMATLFMLVLDALLYLVLALYFDKITL 425

  Fly   489 KKYHATRSAVGRLKRQIPEVSFSKTSAEALI--------------------EFRG--------VW 525
            .||...||.:..||   ....|.:..|..::                    ||:|        :.
Mouse   426 SKYGHQRSPLFFLK---SSYWFKRRGASHVVLENEIDSDPSLNDSLEPVSPEFQGKEAIRIKNLK 487

  Fly   526 QKYS---NSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGE--IYLSGFNIVT 585
            ::||   .....::.:..::|.|::.|||||:.:||:|:|..|.|.:.|..|.  ||....:.:.
Mouse   488 KEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINTLSGLSPPTTGSVTIYNQTVSEMD 552

  Fly   586 QRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVND 650
            .....|..:.:.......|..|.|.::|...::::|:...|.:.|.:.:|:.|::|:.:..|..:
Mouse   553 DSDAVLTITGVCPQSNVQFGFLTVRENLRLFAKIKGILPHEVEQEVQQVLQDLEMENIQDILAQN 617

  Fly   651 LTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGI 715
            |:.||:|.|....|..|..|:::||:|..|:|.......::|:.:::..|.|.|::.....|..:
Mouse   618 LSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKERRAGRVIVFSTQFMDEADIL 682

  Fly   716 ADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCA 780
            |||...:|.|:|:..|:...|.:.....|.|.:..||.|..:.:.:.:...|.:..:.:...:..
Mouse   683 ADRKVFISNGRLKCAGSSLFLKKKWGIGYHLSLHLNEACDPEGITSLVKKHISDARLTTQSEERL 747

  Fly   781 SFLVKHKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQPGLQTLLA 845
            .:::..:...:..:|..:|.|..|. .:..:.:...:::::...|  ..||..:....|    :.
Mouse   748 VYILPLERTNKFPDLYRDLDRCSNQ-GIEDYGVSMTTLNEVFLKL--EGKSMADESDVG----IC 805

  Fly   846 SRQQSAKRRFIIPTMYLLEELRQLLIADTRN--------WFLPI----------LKLTLPSLVVV 892
            .|.||...|    .|..|.||.|:|..|:..        |...:          ||....||:.|
Mouse   806 GRLQSDGAR----DMESLVELEQVLSLDSSGSSVSGMALWRQQLCAVAKVRFFKLKNERKSLMTV 866

  Fly   893 --------------------------WTLSMPYFWHNCRQPGHITFPMSDHGDGIILMQKDTLDS 931
                                      |.||...::.:..||                 .:|.| :
Mouse   867 LLLFGISFVPQLLEHLVYKVYHKSYSWGLSPSMYFLSPGQP-----------------PQDPL-T 913

  Fly   932 ELLVASEMYAKVGVTEVDKTVDITTFIYNYEYKNSLLSDADIM------EAVIFSNVQIEVLFNT 990
            .|||         :.....::|  .|::....:...| |.|.:      |..:: |..|.||...
Mouse   914 HLLV---------INRTGSSID--NFVHALRQQGIAL-DLDALGTRNGTEEALY-NGAITVLGEE 965

  Fly   991 KWPHTAPDSLAQALNSLAV---AFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSF 1052
            |....:....|:.||...|   ...:|..||....|.:........:.|:.   |:..|.|
Mouse   966 KALRFSVACNAKRLNCFPVLMDIISNGLLGIFNSSERIQTDRSTVFEEHML---YEYGFMS---- 1023

  Fly  1053 CFCFIW------SIPLLHMTLSRDGRYNYVELI-----------AGMPTIVLIVAFLIYELLVVL 1100
             ..|.|      ..|.:.|....|.:...:..:           .|...:.:.:.|||..|:.::
Mouse  1024 -NAFFWIPVAASLTPYIAMGSISDHKKKVLSQLWTSGLYPSAYWCGQALVDIPIYFLILFLMQIM 1087

  Fly  1101 LALF----------------PINI----AVIFFHWDLLM-----DSNIHIYS-----VYVMFIIA 1135
            .::|                |.:|    ::||..:.:..     ..|..|:|     |.:.||||
Mouse  1088 DSVFSSEEFISVMESLLIQIPCSIGYASSLIFMTYVISFIFRNGRKNSGIWSFFFLIVTIFFIIA 1152

  Fly  1136 ACV-----FSLNILITIMPISDMPFVYLKVLLAYS---------LGI----LVYIAVKELRPFTN 1182
            ..:     ..|.|...::|    ||..:..||.:|         ||.    ||::|:  |.|:
Mouse  1153 TDINEYGFLELLICTFLVP----PFTLIGSLLIFSEVSYDSVDYLGTSESQLVFLAL--LIPY-- 1209

  Fly  1183 PNTAHFLLLDFHPFYALLHNLMRIASISEKIWLCSDRQIYETSVYAD--------QCNTIPNCCD 1239
               .||||     |:.:|.              |.:|.:.:.|:..|        .|..:||
Mouse  1210 ---LHFLL-----FFFILR--------------CLERYLRKKSLRVDPVFRISPRSCPAVPN--- 1249

  Fly  1240 DDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPS 1304
                                                  |.:|   .:.|.|.:.::
Mouse  1250 --------------------------------------PEEP---GEEDEDVQMER--------- 1264

  Fly  1305 ELENTWIHEKSRVSTL---ERNHIESKALHVEHLS----VFFGL--KAAIKHIDFMVNRYQVMSV 1360
                  :.....::||   |:..|.:..|..|::.    .|..:  |.|.::|.|.|.:.:|:.:
Mouse  1265 ------VRTTGAMATLQTDEKPVIIASCLRKEYIGRTKRCFSKMKKKIATRNISFCVKKGEVLGL 1323

  Fly  1361 FGANGTGKSVLLKTILGIYTPSSGRII-----SSKTVPFKSKDLDSCHMVGYSAQEFQTMQLMTI 1420
            .|.||.|||..:..|.|...|::|::.     ....:.|          :||..||......:|:
Mouse  1324 LGHNGAGKSTTISMITGDTIPTAGQVFLKGSGGGAALGF----------LGYCPQENVLWPNLTV 1378

  Fly  1421 LETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILL 1485
            .|..:|...::..|:.......|:|.....|..:....:...|:||.::|...::::.:..::||
Mouse  1379 KEHLELYAAVKGLKKKDAVVTITRLVNALKLQDHLKALVRTLSEGVKRKLCFVLSILGNPPVVLL 1443

  Fly  1486 DDPFTHLDIVSQRSMLHIIHDL---RRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIGE 1543
            |:|.|.:|...|:.|...|...   ..||..:     .|.|...|.    |:|.:....:..||.
Mouse  1444 DEPSTGMDPEGQQQMWQAIRATFTNTERGALL-----TTHYMAEAEAVCDRVAIMVSGRLRCIGS 1503

  Fly  1544 REEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSAD 1608
            .:.::.. :...|::|.::.......|:                        :.|....|..:|.
Mouse  1504 IQHLKSK-FGKDYLLEMKVKTPSQVEPL------------------------NTEIMRLFPQAAR 1543

  Fly  1609 RWKYLKLCGV---IENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFYSFSVSQPS 1670
            :.:|..|...   :|:|.|               ||...:.:.|:.:..     |...:|:||.:
Mouse  1544 QERYSSLMVYKLPVEDVRP---------------LSEAFFKLERLKENF-----DLEEYSLSQST 1588

  Fly  1671 VNSVFLSIHRQKSNKD 1686
            :..|||.:.:::...|
Mouse  1589 LEQVFLELSKEQELDD 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	111/513 (22%)
		ABC_subfamily_A	519..737	CDD:213230	59/250 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	46/200 (23%)
Abca9	NP_671753.2	rim_protein	<128..1600	CDD:130324	332/1724 (19%)