DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and ABCA3

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_001080.2	Gene:	ABCA3 / 21	HGNCID:	33	Length:	1704	Species:	Homo sapiens

Alignment Length:	1915	Identity:	404/1915 - (21%)
Similarity:	716/1915 - (37%)	Gaps:	471/1915 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIR----SSSDSNMRDYSIRAEAELLEFSWSSL 71
            ||:|||:..||...||.:|.|.||::.|..|:::|    |.:..|...|..::..||..|
Human     9 LLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLF----- 68

  Fly    72 IGKIQERRAKMASKQRNFTTNVFIP---DIRVAFAP-NSNAA------LRRLMGDALGKLSMSED 126
                             ||   |.|   ...:|:.| :|:||      :||.:...:.......:
Human    69 -----------------FT---FPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSE 113

  Fly   127 KIVDFENCNDMRIHAASEHYLASVCFRN-VDESLNGLPTVLNFAIIMPSELRNYEDTWIG----- 185
            |  |||:.  :|....|...||:|.|.: .:.|...||..:.:.:......|||..|..|
Human   114 K--DFEDY--IRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLK 174

  Fly   186 --DSWKETT--TLMDRDVAEEDEFDEDGYTDYMGEGFVPLQYHISMQFLR-----ATASKVEKLP 241
              :.|..|:  .|.......|....:.|...|:.|||:.:|:.:....:.     ||....::|
Human   175 ETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRL- 238

  Fly   242 KVVMRRFNENPNVL--LSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATL 304
            .|.::||...|.:.  ....|...:.||:||.|.:....:...:|:|:|...:..::::..|:.|
Human   239 TVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWL 303

  Fly   305 QMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAM 369
            ..:|||...|...||.:..:|:|..::.....|.:::....::|.||:.:..|..|...::::..
Human   304 HWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFF 368

  Fly   370 RRSRVAMVMAPIIWILLALP-----------LLSKKELLSDGPDVFYGFATVLLCNVSFSRG--- 420
            .::.:|......::....:|           .||:|            ..:.||.||:.:.|
Human   369 SKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQK------------LCSCLLSNVAMAMGAQL 421

  Fly   421 ----------------LSKIFYIEDYTLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLA 469
                            ||.:...:|:..|..:|..:...|.   :|    :|.:|::.:|.....
Human   422 IGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVL---YG----LVTWYMEAVFPGQFG 479

  Fly   470 MIFENNAYFWLAIRVKNLLKKYHA--TRSAVGRLKRQI-PEVSFSKTSAEALIE--FRGVWQKYS 529
            :  ....||:       ::..|..  .|:..|:.:... ||.:......||..|  ..|:..|:.
Human   480 V--PQPWYFF-------IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHL 535

  Fly   530 NSTY--------VVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQ 586
            :..:        .|:|:.||:|.|::..|||||.:||:|.:.||.|...|..|..|:||:.|...
Human   536 SKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQD 600

  Fly   587 RKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDL 651
            ..:..|:..:...:..||..|.|.:||.|.::|:|||:.:...|.|.:|..:.|||...:....|
Human   601 MVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFL 665

  Fly   652 TIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIA 716
            :.|.||.|....|...|::::|||:|..|:|.......:.|:..||.:|:|..|::....|..:.
Human   666 SGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLG 730

  Fly   717 DRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCAS 781
            |||.:::||:||..|:...|.:.....|.:.:.....|:.:|:...:...:|...::|......|
Human   731 DRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELS 795

  Fly   782 FLVKHKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQ-----PGLQ 841
            |::..:.......|...|.:.:.:|.:.||.          ||:.|.::..|..|:     ..:|
Human   796 FILPRESTHRFEGLFAKLEKKQKELGIASFG----------ASITTMEEVFLRVGKLVDSSMDIQ 850

  Fly   842 TL-LASRQQSAKRRF--------IIPTM-------YLLEELRQLLIADT---------------- 874
            .: |.:.|...:||.        :...|       .|:||.|..:..:|
Human   851 AIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKK 915

  Fly   875 -----RNW-------FLPILKLTLPSLVVVWTLSM---PYFWHNCRQPGHITFPMSDHGDGIILM 924
                 |.|       .:|:..:||..|.:.::..:   |.......:.|....|.|..|...:..
Human   916 AAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQ 980

  Fly   925 Q-----KDTLDSELLVASEMYAKVGVTEVDKTVDITTFIYNYEYKNSL------------LSDAD 972
            |     ||.|.:|   ..|....:|        |:..|:.   ::.|:            .|..|
Human   981 QLSEHLKDALQAE---GQEPREVLG--------DLEEFLI---FRASVEGGGFNERCLVAASFRD 1031

  Fly   973 IMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTL--QL 1035
            :.|..:     :..|||.:..|:...:||...|.|........|.|.|.....|.|.:...  |.
Human  1032 VGERTV-----VNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQF 1091

  Fly  1036 HLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAG------------------- 1081
            :....|:|:  |..|.|...|:.|...:.....|..:..:|:.::|
Human  1092 NEGRKGFDI--ALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFL 1154

  Fly  1082 MPTIVLIVAFLIYE-------------LLVVLL---ALFPINIAVIFFHWDLLMDSNIHIYSVYV 1130
            :|:::|:|.|..::             ||::||   |:.|:...:.||
Human  1155 IPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFF----------------- 1202

  Fly  1131 MFIIAACVFS----LNIL--------ITIMPISDMPFVYLKVLLAYSLGILVYIAVKELRPFTNP 1183
             |:.||..::    .|||        :|||.|..:....|...|.:...:|             |
Human  1203 -FLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVL-------------P 1253

  Fly  1184 NTAHFLLLDFHPFYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNCC---DDDAQEF 1245
            |  |.|.:....||                      :.|||..|........:.|   :...||.
Human  1254 N--HCLGMAVSSFY----------------------ENYETRRYCTSSEVAAHYCKKYNIQYQEN 1294

  Fly  1246 YHL-------RYLC------CVYLLLVVVWISIFIFLKSHMVK---------RRPRQPKYFWDSD 1288
            ::.       |::.      |.||:|:       ..:::::::         ||.|.....:...
Human  1295 FYAWSAPGVGRFVASMAASGCAYLILL-------FLIETNLLQRLRGILCALRRRRTLTELYTRM 1352

  Fly  1289 PDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLSVFFGLKA---AIKHIDF 1350
            |....||::             ..|::|:.....:.:....|.::.||..:..:.   |:..:..
Human  1353 PVLPEDQDV-------------ADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSL 1404

  Fly  1351 MVNRYQVMSVFGANGTGKSVLLKTILGIYTPSS------GRIISSKTVPFKSKDLDSCHMVGYSA 1409
            .|.:.:...:.|.||.||:...|.:.|..:.:|      |..|||.....:.:       :||..
Human  1405 AVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQR-------IGYCP 1462

  Fly  1410 QEFQTMQLMTILETWDLILRIR-------------RSKQISFRAEATKLCKIFGLYKYRFNSLSI 1461
            |....:..||..|...:..|:|             ..:.:.....|.||.:.:
Human  1463 QFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTY------------ 1515

  Fly  1462 CSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTP 1526
             |.|..::||.||||:.:..:|.||:|.|.:|.|::|.:...:...|..|.:||.| |.:.....
Human  1516 -SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT-SHSMEECE 1578

  Fly  1527 AL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTG 1589
            ||  |:|.:.......:|..:.::..:.|.|                     |..||....|...
Human  1579 ALCTRLAIMVQGQFKCLGSPQHLKSKFGSGY---------------------SLRAKVQSEGQQE 1622

  Fly  1590 TLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTL 1654
            .|     :||.|                .::..||.:::::.....|.:.|.......:::...|
Human  1623 AL-----EEFKA----------------FVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGIL 1666

  Fly  1655 HRNKQDF--YSFSVSQPSVNSVFLSI-HRQ 1681
            .:.|:.:  ..:||||.|:..||||. |.|
Human  1667 EKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	124/508 (24%)
		ABC_subfamily_A	519..737	CDD:213230	72/227 (32%)
		P-loop_NTPase	1330..1517	CDD:422963	48/208 (23%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468	38/216 (18%)
		CcmA	530..839	CDD:224054	87/318 (27%)
		ABC_subfamily_A	530..751	CDD:213230	70/220 (32%)
		ABC2_membrane_3	923..1261	CDD:289468	76/391 (19%)
		ABC_subfamily_A	1381..1602	CDD:213230	55/241 (23%)
		drrA	1397..1692	CDD:130256	76/357 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020