DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and ABCA1

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_005493.2	Gene:	ABCA1 / 19	HGNCID:	29	Length:	2261	Species:	Homo sapiens

Alignment Length:	2014	Identity:	395/2014 - (19%)
Similarity:	720/2014 - (35%)	Gaps:	592/2014 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IRSSSDSNMRDYSIRAEAELLEFSWSSLIGKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNA 108
            :|...||...|:....:.:.|:::...::..:.:....:.|      :|..:...|.|| ..:|.
Human   436 VRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQS------SNGSVYTWREAF-NETNQ 493

  Fly   109 ALRRLMGDALGKLSMSEDKIVDFENCNDMRIHAASEHYLASVCFRNVDESLNGLPTVLNFAIIMP 173
            |:|.:            .:.::..|.|.:. ..|:|.:|.:.....:||.......|  |..|.|
Human   494 AIRTI------------SRFMECVNLNKLE-PIATEVWLINKSMELLDERKFWAGIV--FTGITP 543

  Fly   174 SELR-----NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTD------------YMGEGFVPL 221
            ..:.     .|:            ..||.|..|.....:|||.|            |:..||..|
Human   544 GSIELPHHVKYK------------IRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYL 596

  Fly   222 QYHISMQFLRATASKVEKLPKVVMRRFNENPNVLLSEGI-----GTSVVLLILLGFMFPVTILTT 281
            |..:....:|.... .||...|.|::.   |.....:.|     ..|:.|.:.|.:::.|.::..
Human   597 QDVVEQAIIRVLTG-TEKKTGVYMQQM---PYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIK 657

  Fly   282 LIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPW-- 344
            .||.|:|...:..::|:....::...:||.:.....|:::.|:.::||:.        |..|:
Human   658 GIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLG--------NLLPYSD 714

  Fly   345 PILLCFLISYGCSVTSL-IILMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFA 408
            |.::...:|....||.| ..|:::...|:.:|.....||:..|.||.     :|......:.||.
Human   715 PSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY-----VLCVAWQDYVGFT 774

  Fly   409 ----TVLLCNVSFSRGLSKIFYIEDYTLGVTIGKYMFYRVSKSDFGI------------FVPIVC 457
                ..||..|:|..|.......|:..:||.........|.:..|.:            ...::.
Human   775 LKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMT 839

  Fly   458 FYVQTIF-------------CTLLAMIFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVS 509
            :|::.:|             ||         ..:|..        :....:|..|..:::|.|:.
Human   840 WYIEAVFPGQYGIPRPWYFPCT---------KSYWFG--------EESDEKSHPGSNQKRISEIC 887

  Fly   510 FSK--TSAEALIEFRGVWQKYSNSTYVVQD-ITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRP 571
            ..:  |..:..:..:.:.:.|.:...|..| :.||.|.|::.:.||||.:||:|.:.:|.|...|
Human   888 MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPP 952

  Fly   572 KLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLR 636
            ..|..|:.|.:|.::.....:|..:...:..||..|.|.:|:.|.:||:|||:...|.|.:.:..
Human   953 TSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMAL 1017

  Fly   637 YLKLEDWE-KTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNR 700
            .:.|...: |:..:.|:.|.:|.|....||.||:::||||:|..|:|.......:.|:|..::.|
Human  1018 DVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGR 1082

  Fly   701 SIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMAT 765
            :|..::::...|..:.|||.::|.|||...|:...|...|...|.|.:..      |||
Human  1083 TIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVK------KDV------ 1135

  Fly   766 FIPEIEMDSILADC------ASFLVK----------------HKYHTELINL--IENL------- 799
                   :|.|:.|      .|:|.|                |:..|..|::  |.||
Human  1136 -------ESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSE 1193

  Fly   800 ARLKNDLN-----VYSFE----------IHECSIDDILASL----YTRDKSTLE------FGQPG 839
            |||..|:.     |..:|          .||  |||.|:.|    |...::|||      ..:.|
Human  1194 ARLVEDIGHELTYVLPYEAAKEGAFVELFHE--IDDRLSDLGISSYGISETTLEEIFLKVAEESG 1256

  Fly   840 LQ------TLLASR-------QQSAKRRF------------------------------------ 855
            :.      ||.|.|       :||..|.|
Human  1257 VDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKG 1321

  Fly   856 --IIPTMYLLEELRQLLIA-DTRNWFLPILKLTLPSLVV----VWTLSMPYF----------W-H 902
              :....::....::|||| .:|..|  ..::.||::.|    |::|.:|.|          | :
Human  1322 WKLTQQQFVALLWKRLLIARRSRKGF--FAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY 1384

  Fly   903 N-----------------------CRQPGHIT--------------------------------- 911
            |                       .:.||..|
Human  1385 NEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLF 1449

  Fly   912 ------------------------FPMSDHGDGII---LMQKDTLD----------SELLVASEM 939
                                    .|:...|.|.:   ..:::|.|          |:.||  :.
Human  1450 QNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLV--KT 1512

  Fly   940 YAKVGVTEVDKTVDITTFIY---------------NYEYKNSLL-----------SDAD------ 972
            |.::....:...:.:..|.|               :.|..:::.           |.||
Human  1513 YVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSL 1577

  Fly   973 --IMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDA---------GIKVELEVLP 1026
              .|..:...| .::|.||.|..|    :::..||.:..|.:..:.         ||......|.
Human  1578 GRFMTGLDTKN-NVKVWFNNKGWH----AISSFLNVINNAILRANLQKGENPSHYGITAFNHPLN 1637

  Fly  1027 FSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAF 1091
            .:.....::.|.....|::.:.|:.|...|:.:..::.:...|..:..:::.|:|:..::..::.
Human  1638 LTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSN 1702

  Fly  1092 LIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFV 1156
            .::::...::   |..:.:|                :::.|...:.|.|.|:.:..:
Human  1703 FVWDMCNYVV---PATLVII----------------IFICFQQKSYVSSTNLPVLAL-------- 1740

  Fly  1157 YLKVLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPFYALL-------------HNLMRIAS 1208
             |.:|..:|:..|:|.|   ...|..|:||:.:|...:.|..:.             :.|..|..
Human  1741 -LLLLYGWSITPLMYPA---SFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIND 1801

  Fly  1209 ISEKIWL-----CSDRQIYETSVYADQCNTIPNCCDDDAQE-FYHLRYLCCVYLLLV-------- 1259
            |.:.::|     |..|.:.:         .:.|....||.| |...|::..:...||
Human  1802 ILKSVFLIFPHFCLGRGLID---------MVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMA 1857

  Fly  1260 ---VVWISIFIFLK-SHMVKRRPRQPKY--FWDSDPDSKYD-QNIL------HIMEPSELENTWI 1311
               ||:..|.:.:: ...::.||...|.  ..|.|.|.:.: |.||      .|:|..||  |.|
Human  1858 VEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKEL--TKI 1920

  Fly  1312 HEKSRVSTLERNHIESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTIL 1376
            :.:.|                         |.|:..|...:...:...:.|.||.|||...|.:.
Human  1921 YRRKR-------------------------KPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLT 1960

  Fly  1377 GIYTPSSGRIISSKTVPFKSKDLDSCHMV----GYSAQEFQTMQLMTILETWDL--ILRIRRSKQ 1435
            |..|.:.|....:     |:..|.:.|.|    ||..|.....:|:|..|..:.  :||....|:
Human  1961 GDTTVTRGDAFLN-----KNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKE 2020

  Fly  1436 ISFRAE--ATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQR 1498
            :....|  ..||    ||.||........|.|..::||..:||:....::.||:|.|.:|..::|
Human  2021 VGKVGEWAIRKL----GLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARR 2081

  Fly  1499 SMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETR 1561
            .:.:....:.:.|.|::.| |.:.....||  |||.:.......:|..:.: :|.:...|.:..|
Human  2082 FLWNCALSVVKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFRCLGSVQHL-KNRFGDGYTIVVR 2144

  Fly  1562 IHLAELGSPIDFDSQSTEAKEDRAGTT--GTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFP 1624
            |    .||..|.     :..:|..|..  |::|:.||:..
Human  2145 I----AGSNPDL-----KPVQDFFGLAFPGSVLKEKHRNM------------------------- 2175

  Fly  1625 HAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSIHRQKSNKD 1686
                       :.:.|.|.:..::||...|.::|:..:  .:||||.:::.||::..:.:|:.|
Human  2176 -----------LQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	116/501 (23%)
		ABC_subfamily_A	519..737	CDD:213230	65/219 (30%)
		P-loop_NTPase	1330..1517	CDD:422963	47/194 (24%)
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	395/2014 (20%)
ABCA1	NP_005493.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1312		2/28 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920