DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and ced-7

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_001255012.1	Gene:	ced-7 / 176352	WormBaseID:	WBGene00000421	Length:	1758	Species:	Caenorhabditis elegans

Alignment Length:	1835	Identity:	375/1835 - (20%)
Similarity:	670/1835 - (36%)	Gaps:	467/1835 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FCLLVWKNFQKQKHNKLVLILSLVLP--VMSSLFLLFIR----SSSDSNMRD-YSIRAEAELLEF 66
            |.||:||::...:.||:..:..|::|  ::..|..|.::    :||..|:.| :.::...|.: |
Worm    74 FSLLLWKDWVLLRRNKVWTLFELIIPCLLLGPLVYLVVKNADHTSSPENIYDNFQVKGTVEDV-F 137

  Fly    67 SWSSLIGKIQER-----------RAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGK 120
            ..|:.|..|.:|           .:|.|:.:|.      :.|:...||....:|..:|.    .|
Worm   138 LESNFIKPIYKRWCLRSDVVVGYTSKDAAAKRT------VDDLMKKFAERFQSAKLKLS----VK 192

  Fly   121 LSMSEDKIVDFENCNDM----RIHAASEHYLASVCFRNVDESLNGLPTVLNFAIIMPSELRNYED 181
            ...||::::.... ||:    ....|...|.|.|.|..||.:    ...||:.|::.   :..|:
Worm   193 NESSEEQLLTVLR-NDLPMLNETFCAINSYAAGVVFDEVDVT----NKKLNYRILLG---KTPEE 249

  Fly   182 TWIGDSWKETTTLMDRDVAEEDEFDEDGYT----------------DYMGEGFVPLQYHISMQFL 230
            ||                    ...|..|.                .|....|:..|:.|...||
Worm   250 TW--------------------HLTETSYNPYGPSSGRYSRIPSSPPYWTSAFLTFQHAIESSFL 294

  Fly   231 RATASKVEKLPKVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFP-----VTILTTLIVEERELG 290
            .:..|....|| :.:|...| |....|     ||...|   ..||     ||.:..:.:......
Worm   295 SSVQSGAPDLP-ITLRGLPE-PRYKTS-----SVSAFI---DFFPFIWAFVTFINVIHITREIAA 349

  Fly   291 QRYMLK----ILNASATLQMAAWFFNVFTHFLI------------------TSLLITIL------ 327
            :.:.:|    .:..|..:..||.....|..|.:                  .:|::|:|
Worm   350 ENHAVKPYLTAMGLSTFMFYAAHVVMAFLKFFVIFLCSIIPLTFVMEFVSPAALIVTVLMYGLGA 414

  Fly   328 --------------------LKIEWNGATAAVNKCPWP----ILLCFLISYGCSVTSLIILMTSA 368
                                :.:.| ||...::....|    |..|||  ||.::.....|...|
Worm   415 VIFGAFVASFFNNTNSAIKAILVAW-GAMIGISYKLRPELDQISSCFL--YGLNINGAFALAVEA 476

  Fly   369 ----MRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIED 429
                |||.|.                |:...:.:|.             ::.||.|.:.:..|.|
Worm   477 ISDYMRRERE----------------LNLTNMFNDS-------------SLHFSLGWALVMMIVD 512

  Fly   430 YTLGVTIGKYMFYRV-SKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLA--IRVKNLLKKY 491
             .|.::||..:...: :.:||.:         :|:|........||......|  .|:...:...
Worm   513 -ILWMSIGALVVDHIRTSADFSL---------RTLFDFEAPEDDENQTDGVTAQNTRINEQMNPM 567

  Fly   492 HAT-----RSAVGRLKRQIPEVSFSKTSAEALIEFRG---VWQKYSNSTYVVQDITLNVYAGEVV 548
            .:|     .:....|.....|...::.:|.|.|..|.   :|.  :.....|..::|....|:..
Worm   568 ASTSLNPPNADSDSLLEGSTEADGARDTARADIIVRNLVKIWS--TTGERAVDGLSLRAVRGQCS 630

  Fly   549 ALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHL 613
            .|||||.:||||....:.|..||..|.|.:.|:::..:..|..::..:...|..|:.:|.|.:||
Worm   631 ILLGHNGAGKSTTFSSIAGIIRPTNGRITICGYDVGNEPGETRRHIGMCPQYNPLYDQLTVSEHL 695

  Fly   614 VFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPF 678
            ..:..|:|..:.:.|.:.|.||..:||:..|.....:|:.|.:|.|....|..|.:::|:||:|.
Worm   696 KLVYGLKGAREKDFKQDMKRLLSDVKLDFKENEKAVNLSGGMKRKLCVCMALIGDSEVVLLDEPT 760

  Fly   679 DGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNES 743
            .|:|.........|:..:|.||:|..|::....|..:.|.:|::|.|||.|.||.:.|.:.....
Worm   761 AGMDPGARQDVQKLVEREKANRTILLTTHYMDEAERLGDWVFIMSHGKLVASGTNQYLKQKFGTG 825

  Fly   744 YRLIIF----GNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKH----KYHTELINLIENLA 800
            |.|.:.    |:::                 :|..||.|..:..||.    :.|.:.|.:|...|
Worm   826 YLLTVVLDHNGDKR-----------------KMAVILTDVCTHYVKEAERGEMHGQQIEIILPEA 873

  Fly   801 RLKNDLNVY-SFEI-----HECSIDDILASLYTRDKSTLEFGQPG--LQTL-------------- 843
            |.|..:.:: :.|.     :..::.|.:.:......:|||....|  |.||
Worm   874 RKKEFVPLFQALEAIQDRNYRSNVFDNMPNTLKSQLATLEMRSFGLSLNTLEQVFITIGDKVDKA 938

  Fly   844 LASRQQS--------AKRRFIIPTMY----------------------------------LLEEL 866
            :||||.|        |....:.|..|                                  .:..:
Worm   939 IASRQNSRISHNSRNASEPSLKPAGYDTQSSTKSADSYQKLMDSQARGPEKSGVAKMVAQFISIM 1003

  Fly   867 RQLLIADTRNW-------FLPILKLTL-PSLVVVWTLSMPYFWHNCRQPGHITFPMSDHGDGIIL 923
            |:..:...|||       .:||:.|.| .||..:.:.:...|......|..|     :....:..
Worm  1004 RKKFLYSRRNWAQLFTQVLIPIILLGLVGSLTTLKSNNTDQFSVRSLTPSGI-----EPSKVVWR 1063

  Fly   924 MQKDTLDSELLVASEMYAKVGVTEVDKTVDITTFIYNYEYKNSLLSDADIMEAVI---------- 978
            .:..|:..|.....::..|.|..||          .||..||.|   .:|.:::|
Worm  1064 FENGTIPEEAANFEKILRKSGGFEV----------LNYNTKNPL---PNITKSLIGEMPPATIGM 1115

  Fly   979 -FSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGY 1042
             .::..:|.|||.::.|..|..::....:.....:|.:....|.|.....|..:.|...|    .
Worm  1116 TMNSDNLEALFNMRYYHVLPTLISMINRARLTGTVDAEISSGVFLYSKSTSNSNLLPSQL----I 1176

  Fly  1043 DLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYE----LLVVLLAL 1103
            |::.|..|...|..:.|..::.:...|..::.:.:.:.|:..|....|.|||:    .|:.|:.|
Worm  1177 DVLLAPMLILIFAMVTSTFVMFLIEERTCQFAHQQFLTGISPITFYSASLIYDGILYSLICLIFL 1241

  Fly  1104 FPI--------NIAVIFFHWDLLMDSNI-HIYSVYVMFIIAACVFSLNILITIMPISDMPFVYLK 1159
            |..        ::|::...|.|...|:: .||:|..:|...:   ..|:|:.|..:.......|.
Worm  1242 FMFLAFHWMYDHLAIVILFWFLYFFSSVPFIYAVSFLFQSPS---KANVLLIIWQVVISGAALLA 1303

  Fly  1160 VLLAYSL--------GILVYIAVKELRPFTNPNTAHFLLLDFHPFYALLHNLMRIASI-----SE 1211
            |.|.:.:        .|||             |...|||    |.||....::.|.:.     ||
Worm  1304 VFLIFMIFNIDEWLKSILV-------------NIFMFLL----PSYAFGSAIITINTYGMILPSE 1351

  Fly  1212 KI--WLCSDRQIYETSVYADQC-------NTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFI 1267
            ::  |              |.|       .|...|.                        .::|:
Worm  1352 ELMNW--------------DHCGKNAWLMGTFGVCS------------------------FALFV 1378

  Fly  1268 FLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHV 1332
            .|:...|:|...|   .|.....|  ..|:..:|....:..:...|:.||   .|.:.::.||.:
Worm  1379 LLQFKFVRRFLSQ---VWTVRRSS--HNNVQPMMGDLPVCESVSEERERV---HRVNSQNSALVI 1435

  Fly  1333 EHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKSK 1397
            :.|:..||...|:..:...|::.:...:.|.||.||:.....:.|....|||..:      ...:
Worm  1436 KDLTKTFGRFTAVNELCLAVDQKECFGLLGVNGAGKTTTFNILTGQSFASSGEAM------IGGR 1494

  Fly  1398 DLDSCHMVGYSAQEFQTMQL-MTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSI 1461
            |:.....:||..| |..:.| :|..|:.:::.::...:  :::|:|..:.:..|:..:....:..
Worm  1495 DVTELISIGYCPQ-FDALMLDLTGRESLEILAQMHGFE--NYKAKAELILECVGMIAHADKLVRF 1556

  Fly  1462 CSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTP 1526
            .|.|..:::|:|:||::..::|:||:|...:|..::|.:..::...|...:|.:...|.:.....
Worm  1557 YSGGQKRKISVGVALLAPTQMIILDEPTAGIDPKARREVWELLLWCREHSNSALMLTSHSMDECE 1621

  Fly  1527 AL--RMATLSYPGIAVIGEREEMQQNYYSSYYM----------------VETRIHLAEL-----G 1568
            ||  |:|.|:...:..||..:|::..|.::|.|                |:||:..:.|     .
Worm  1622 ALCSRIAVLNRGSLIAIGSSQELKSLYGNNYTMTLSLYEPNQRDMVVQLVQTRLPNSVLKTTSTN 1686

  Fly  1569 SPIDFDSQSTEAKED 1583
            ..::...|..:.|||
Worm  1687 KTLNLKWQIPKEKED 1701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	116/537 (22%)
		ABC_subfamily_A	519..737	CDD:213230	65/220 (30%)
		P-loop_NTPase	1330..1517	CDD:422963	40/187 (21%)
ced-7	NP_001255012.1	ABC2_membrane_3	<286..445	CDD:289468	30/169 (18%)
		CcmA	600..885	CDD:224054	81/303 (27%)
		ABC_subfamily_A	600..819	CDD:213230	65/220 (30%)
		ABC2_membrane_3	1014..1379	CDD:289468	84/444 (19%)
		ABC2_membrane_4	1154..1348	CDD:289500	46/217 (21%)
		CcmA	1430..1738	CDD:224054	61/281 (22%)
		ABC_subfamily_A	1433..1645	CDD:213230	49/220 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020