Protein Alignment CG43672 and Abca2

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_006497672.1
• Gene: Abca2 / 11305
• MGIID: 99606
• Length: 2464
• Species: Mus musculus
• Alignment Length: 2117
• Identity: 399/2117 - (18%)
• Similarity: 735/2117 - (34%)
• Gaps: 637/2117 - (30%)

  Fly    17 FQKQKHNKLVLILSLV--------LPVMSSLFLLFIRSSSD----SNMRDYS---IRAEAELLEF 66
            |..::...|.|::.|:        .||.|....:.::::..    .|:..|:   :....|:..|
Mouse   469 FTSKEQRNLGLLVHLMTSNPKILYAPVGSEADRVILKANETFAFVGNVTHYAQVWLNISTEIRSF 533

  Fly    67 SWSSLIGKIQER---------RAKMASKQRNFTTNVFIPDIRVAFA-PNSNAALRRL--MGDA-- 117
            ...   |::|:.         ..::..:..|.:.....|.:|..|: ||..|.|::|  :.:|
Mouse   534 LEQ---GRLQQHLQWLQQYVADLQLHPEAMNLSLEELPPALRQDFSLPNGTALLQQLDTIDNAAC 595

  Fly   118 -----LGKLSM-------SEDKIVDFENCNDMRIHAASEHY------LASVCFRNVDESLNGLPT 164
                 :.|:|:       .|:.||::         ..::.|      .|||.|:...:  ..||.
Mouse   596 GWIQFMSKVSVDIFKGFPDEESIVNY---------TLNQAYQDNVTVFASVIFQTRKD--GSLPP 649

  Fly   165 VLNFAIIMPS-------ELRN----------------YEDTWIGDSWKET--TTLMDRDVAEEDE 204
            .:::.|...|       |:|.                |...||.|..:..  .|.:..||.|...
Mouse   650 HVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIINTFVGHDVVEPGN 714

  Fly   205 FDE-DGYTDYMGEGFVPLQYHISMQFLRATASKVEKLPKVVMRRFNENPNVLLSEGIGTSVVLLI 268
            :.: ..|..|..:.|:.:..|:              :|                        |.:
Mouse   715 YVQMFPYPCYTRDDFLFVIEHM--------------MP------------------------LCM 741

  Fly   269 LLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLK---- 329
            ::.:::.|.:....||.|:|...:.::|.:..:..:...|||...|....|:...:|.:||
Mouse   742 VISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQV 806

  Fly   330 -------IEWNG-ATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILL 386
                   |.|.. |..||.    .|:.|||:|         :|.:.|    ::|.....||:.|.
Mouse   807 LMHSHVLIIWLFLAVYAVA----TIMFCFLVS---------VLYSKA----KLASACGGIIYFLS 854

  Fly   387 ALPLL---SKKELLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTLGVTIGKYMFYR--VSK 446
            .:|.:   .::|:..|....|......|:...:|..| ||.|.:.: ..||.|..:.|.:  |..
Mouse   855 YVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG-SKYFALYE-VAGVGIQWHTFSQSPVEG 917

  Fly   447 SDFGIFVPIVCFYVQTIFCTLLAMIFE----------NNAYFWLAIRVKNLLKKY---------- 491
            .||.:.:.:....|.|:...:|....|          ...||       .|.|.|
Mouse   918 DDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYGLPRPWYF-------PLQKSYWLGSGRTEAW 975

  Fly   492 -------HATRSAVGRLKRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVV-------------- 535
                   |..|.:|      :.|.......:....|.||:.::.::...||
Mouse   976 EWSWPWAHTPRLSV------MEEDQACAMESRHFEETRGMEEEPTHLPLVVCVDKLTKVYKNDKK 1034

  Fly   536 ---QDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSIS 597
               ..::||:|..:||:.||||.:||:|.:.:|.|...|..|...:.|.:|.|:..|..||..:.
Mouse  1035 MALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMC 1099

  Fly   598 MSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFL 662
            ..:..||..|.|.:||.|.|||:.:::.|.:.|...::..|:|.:...:||..|:.|.:|.|...
Mouse  1100 PQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRKETDKMIEDLELSNKRHSLVQTLSGGMKRKLSVA 1164

  Fly   663 CAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKL 727
            .||.||::.:|||:|..|:|.......:.|||..|..|:|..::::...|..:.|||.::|.|||
Mouse  1165 IAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKL 1229

  Fly   728 QAFGTVKKLCRMLNESYRLIIFGN----------------------EKCSFKDVYAFMATFIPEI 770
            :..|:...|.....:.|||.:...                      ..||...|    :.||.:.
Mouse  1230 KCCGSPLFLKGAYGDGYRLTLVKQPAEPGTSQEPGLASSPSGCPRLSSCSEPQV----SQFIRKH 1290

  Fly   771 EMDSILADCASFLVKHKYHTELI------NLIENLARLKNDLNVYSFEIHECSIDDILASLYTRD 829
            ...|:|....|..:.:...:|.:      .|.:.|....:.|::.||.:.:.:::::...:...|
Mouse  1291 VASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEED 1355

  Fly   830 KSTLEFGQ-----------PGLQTL---------------LASRQQSAKRRFII----------- 857
            :| ||..:           ||.:.|               ||..|.|.:....:
Mouse  1356 QS-LENSEADVKESRKDVLPGAEGLTAVGGQAGNLARCSELAQSQASLQSASSVGSARGEEGTGY 1419

  Fly   858 ----------------PTMYLLEELRQLLIADT-------RNWFLPI------------------ 881
                            |....|:|.....:|..       ..|:|.:
Mouse  1420 SDGYGDYRPLFDNLQDPDNVSLQEAEMEALAQVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNS 1484

  Fly   882 ----LKLTLPSLVVVWTLSM----------------PYFWHNCRQP--GHITFPMSDHGDGIILM 924
                .::.||:..|...:::                |..:||..||  ..|.:...:..:..:.:
Mouse  1485 KALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERQEYRLRL 1549

  Fly   925 QKDTLDSELLVASEMYAKVGVTEVDK--------------------------------------- 950
            ..|....:|:....:.:.||.|.|.|
Mouse  1550 SPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLP 1614

  Fly   951 ----------------------------------------------------------------- 950
                                                                             
Mouse  1615 LSNFVPPPPSPAPSDSPVSPDEDSLQAWNMSLPPTAGPETWTSAPSLPRLVHEPVRCTCSAQGTG 1679

  Fly   951 -----------------TVDITTFIYNYEYKNSLLSDADIME-----AVIFSNVQ---------- 983
                             |.||.|.|..:.....||..:|...     |:.|.|||
Mouse  1680 FSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVQKSIPASFGAR 1744

  Fly   984 -------------IEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVL----PFS-TI 1030
                         .:||:|.|..|:.|..|....|::..|.:....|......:.    |.: |.
Mouse  1745 VPPMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTS 1809

  Fly  1031 HTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYE 1095
            .:|.|...:.|.|::.|..:.....|:.:..::.:...:..:..:::.::|...::..:|..:::
Mouse  1810 ASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWD 1874

  Fly  1096 LLVVLLALFPINIAV-IFFHWDL-LMDSNIHIYSVYVMFIIAACVFSLNILITIMPIS---DMP- 1154
            :|..|:   |....| |.|.:|| ...|..:..:|..:|::    :..:|...:.|.|   ::|
Mouse  1875 MLNYLV---PATCCVIILFVFDLPAYTSPTNFPAVLSLFLL----YGWSITPIMYPASFWFEVPS 1932

  Fly  1155 --FVYLKVLLAYSLGILVYIAV---------KELRPFTNPNTAHFLLLDFHPFYALLHNLMRIAS 1208
              :|:|.|:..: :||...:|.         |:|:...:...:.||:.   |.|.|.|.||.:|
Mouse  1933 SAYVFLIVINLF-IGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIF---PNYNLGHGLMEMA- 1992

  Fly  1209 ISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFI--FLKS 1271
                    .:..|.|......|.:.:.:..:.|           .|...||.:.:..|:  ||..
Mouse  1993 --------YNEYINEYYAKIGQFDKMKSPFEWD-----------IVTRGLVAMTVEGFVGFFLTI 2038

  Fly  1272 HMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLS 1336
            .......|||             |.:....:|.|.:.....|:.||.   |...::..:.:|:|:
Mouse  2039 MCQYNFLRQP-------------QRLPVSTKPVEDDVDVASERQRVL---RGDADNDMVKIENLT 2087

  Fly  1337 VFF-----GLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGR-IISSKTVPFK 1395
            ..:     |...|:..:...|...:...:.|.||.||:...|.:.|..:.:.|. .::..:|
Mouse  2088 KVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV--- 2149

  Fly  1396 SKDLDSCHM-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKL---CKIFGLYKYRF 1456
            .|||..... :||..|.......:|..|...|..|:|   .|.::.||..:   .:...|.||..
Mouse  2150 LKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLR---GIPWKDEAQVVKWALEKLELTKYAD 2211

  Fly  1457 NSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDT 1521
            ......|.|..::||..|||:.....|.||:|.|.:|..::|.:.::|.||.:.|.|::.| |.:
Mouse  2212 KPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLT-SHS 2275

  Fly  1522 AYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDR 1584
            .....||  |:|.:....:..:|..:.: :|.:...||:..|             ::|::..:|
Mouse  2276 MEECEALCTRLAIMVNGRLRCLGSIQHL-KNRFGDGYMITVR-------------TKSSQNVKD- 2325

  Fly  1585 AGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSR 1649
                  ::|..::.                        ||.|::|.....:|.:.|.|....:::
Mouse  2326 ------VVRFFNRN------------------------FPEAMLKERHHTKVQYQLKSEHISLAQ 2360

  Fly  1650 IVDTLHR--NKQDFYSFSVSQPSVNSVFLSIHRQKSN 1684
            :...:.:  .......:||||.::::||::..:::|:
Mouse  2361 VFSKMEQVVGVLGIEDYSVSQTTLDNVFVNFAKKQSD 2397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	132/526 (25%)
		ABC_subfamily_A	519..737	CDD:213230	72/234 (31%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	50/196 (26%)
Abca2	XP_006497672.1	rim_protein	58..2398	CDD:130324	399/2117 (19%)