Protein Alignment CG43672 and Abca4

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_031404.1
• Gene: Abca4 / 11304
• MGIID: 109424
• Length: 2310
• Species: Mus musculus
• Alignment Length: 2056
• Identity: 393/2056 - (19%)
• Similarity: 708/2056 - (34%)
• Gaps: 573/2056 - (27%)

  Fly    45 RSSSDSNMRDYSIRAEAELLEFSWSS----LIGKIQERRAKMASKQRNFTTNVFIPDIRVA--FA 103
            |::|..|....|:.:. .|.:.:|.:    |:|||                 :|.||...|  ..
Mouse   365 RTTSFCNSLIQSLESN-PLTKIAWRAAKPLLMGKI-----------------LFTPDSPAARRIM 411

  Fly   104 PNSNAALRRLMGDALGKLSMSEDKI-----VDFENCNDMRIHAASEHYLASVCFRNVDESLNGLP 163
            .|:|:....|  |.:.||..:.:::     ..||....|.:...:..:.....|.|......|:.
Mouse   412 KNANSTFEEL--DRVRKLVKAWEEVGPQIWYFFEKSTQMTVIRDTLQHPTVKDFINRQLGEEGIT 474

  Fly   164 T--VLNFAIIMPSELRNYEDTWIGDSWKETTTLMDRDVAEEDEFDE----DGYTDYMGE------ 216
            |  ||||....|.|  ...|......|::...:.||.:...:::.|    |.:..|..|
Mouse   475 TEAVLNFFSNGPQE--KQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYDDEVQLTQR 537

  Fly   217 -----------------GFVP----LQYHISMQFLRATASKVEKLPKVVMRRFNENPNV------ 254
                             |..|    |..|:..: :|.....|||..|:..|.::..|..
Mouse   538 ALSLLEENRFWAGVVFPGMYPWASSLPPHVKYK-IRMDIDVVEKTNKIKDRYWDSGPRADPVEDF 601

  Fly   255 ------------LLSEGIGTSVV--------------------------------LLILLGFMFP 275
                        ::.:||..|.:                                :.::|.:::.
Mouse   602 RYIWGGFAYLQDMVEQGIVKSQMQAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYS 666

  Fly   276 VTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVN 340
            |::....||.|:||..:..||....|..:....||.:.|:...::..|:|:.:   .:|.....:
Mouse   667 VSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLFI---MHGRILHYS 728

  Fly   341 KCPWPILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP----LLSKKELLSDGP 401
            . |: ||..||:::..:......|:::...::.:|...:.:|:..|.||    ...:..:.:|..
Mouse   729 D-PF-ILFLFLLAFATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAWQDRMTADLK 791

  Fly   402 DVFYGFATV-LLCNVSFSRGLSKIFYIEDYTLGV---TIGK-------YMFYRVSKS---DFGIF 452
                  .|| ||.:|:|..|...:...|:..||:   .|||       :.|....|.   |..::
Mouse   792 ------TTVSLLSSVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALY 850

  Fly   453 VPIVCFYVQTIF----CTLLAMIFENNAYFWL-----AIRVKNLLKKYHATRSAVGRLKRQIPE- 507
             .::.:|:..:|    .|.|...|.....:||     :.|.:..|:|......     :.:.||
Mouse   851 -GLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTE-----EMEDPEH 909

  Fly   508 -----VSFSKTSAEALIEFRGVWQKYSNSTY------VVQDITLNVYAGEVVALLGHNASGKSTI 561
                 .||.:.....|:.  ||..|.....:      .|..:.:..|..::.|.||||.:||:|.
Mouse   910 PEGMNDSFFERELPGLVP--GVCVKNLVKVFEPSGRPAVDRLNITFYENQITAFLGHNGAGKTTT 972

  Fly   562 IKMLYGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTE 626
            :.:|.|...|..|.:.:.|.:|.|......::..:...:..||..|.|.:|::|.::|:|.|..|
Mouse   973 LSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEE 1037

  Fly   627 AKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYS 691
            |:||.:|:|....|.........||:.|.:|.|....||.|.:::|:||:|..|:|.......:.
Mouse  1038 AQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWD 1102

  Fly   692 LILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEK--- 753
            |:|..:..|:|..::::...|..:.|||.::|:|:|...||...|.......:.|.:....|
Mouse  1103 LLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQ 1167

  Fly   754 -----------CSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYH------------TELINL 795
                       |:.|.......|.:.||..:.:|......|:...||            .|||.|
Mouse  1168 SQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQELIFL 1232

  Fly   796 IEN--------------LARLKNDLNVYSFEIHECSIDDILASL--------------------- 825
            :.|              |.....||.:.||.|.:..:::|...:
Mouse  1233 LPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQA 1297

  Fly   826 ---------------YTRDKSTLEFGQ--------------PG-------------LQTLLASRQ 848
                           |.:...|...||              ||             :|.||..|.
Mouse  1298 GLRHPCSAPTEKLRQYAQAPHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARLILQHVQALLVKRF 1362

  Fly   849 QSAKR-------RFIIPTMYL------------------------------------------LE 864
            ....|       :.::|..::                                          ||
Mouse  1363 HHTIRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLE 1427

  Fly   865 ELRQLLI--------------------ADTRNWFLPILKLTLPSLV--VVWTLSMPYFWHNCRQP 907
            .|..:|:                    .:..:|..|.:...:..|.  ..||.:.|.....|...
Mouse  1428 VLADVLLNRPGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTR 1492

  Fly   908 GHIT-FPMSDHGDGII-----------LMQ-------------------KDTLDSELLVASEMYA 941
            ..:| .|....|.|.:           ::|                   :.:|.|:..|..:.|.
Mouse  1493 EKLTMLPECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYG 1557

  Fly   942 KVGV------------------TEVDKTVDITTFIYNYEYKNSLLSDADIMEAVIFSNVQIEVLF 988
            .:.:                  :.:.:.::::......|....:|.....:|    :...|:|.|
Mouse  1558 GISIGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLE----TTDNIKVWF 1618

  Fly   989 NTKWPHTAPDSLAQALNSLAVAFIDGDA-----GIKVELEVLPFSTIHTLQLHLNIDGYDLIFAS 1048
            |.|..|.....|..|.|::..|.:..|.     ||.|..:.|..:......:.:.....|.:.|.
Mouse  1619 NNKGWHALVSFLNVAHNAILRASLPRDRDPEEYGITVISQPLNLTKEQLSDITVLTTSVDAVVAI 1683

  Fly  1049 CLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGM-PTIVLIVAFLIYELLVVLLALFPINIAVIF 1112
            |:.|...|:.:..:|::...|..:..:::.|:|: ||...:..||
Mouse  1684 CVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTNFL-------------------- 1728

  Fly  1113 FHWDLLMDSNIHIYSVYVMFIIAACVF------------SLNILITIMPI---SDMPFVYLKVLL 1162
              ||::.      |:|....::.  :|            :|..|::::.:   :.:|.:|....|
Mouse  1729 --WDIMN------YAVSAGLVVG--IFIGFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFL 1783

  Fly  1163 AYSLGILVYIAVKELRPF--TNPNTAHFLLLDFHPFYALLHN---LMRIASISEKIWL-----CS 1217
             :.:....|:|:.....|  .|.:...|:|       .|..|   |:|..::..|:.:     |.
Mouse  1784 -FEVPSTAYVALSCANLFIGINSSAITFVL-------ELFENNRTLLRFNAMLRKLLIVFPHFCL 1840

  Fly  1218 DRQIYE-------TSVYA---DQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSH 1272
            .|.:.:       |.|||   ::.:..|...|...:....:.....||.||.:: |....|| :.
Mouse  1841 GRGLIDLALSQAVTDVYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLL-IQHHFFL-TR 1903

  Fly  1273 MVKRRPRQPKYFWDSDPDSKYDQ-------NILHIMEPSELENTWIHEKSRVSTLERNHIESKAL 1330
            .:....|:|.:  |.|.|...::       |...|::.:||...:....|..
Mouse  1904 WIAEPAREPVF--DEDDDVAEERQRVMSGGNKTDILKLNELTKVYSGSSSPA------------- 1953

  Fly  1331 HVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFK 1395
             |:.|.|  |::..           :...:.|.||.||:...|.:.|..|.:||    ..||..|
Mouse  1954 -VDRLCV--GVRPG-----------ECFGLLGVNGAGKTTTFKMLTGDTTVTSG----DATVAGK 2000

  Fly  1396 S--KDLDSCHM-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFN 1457
            |  ..:...|. :||..|......|:|..|...|..|:|..........|....:..||..|...
Mouse  2001 SILTSISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADR 2065

  Fly  1458 SLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTA 1522
            .....|.|..::||..|||.....|:|||:|.|.:|..::|.:.:.|..:.|.|.:::.| |.:.
Mouse  2066 LAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVVLT-SHSM 2129

  Fly  1523 YSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRA 1585
            ....||  |:|.:.......:|..:.::..:...|      |...::.||          |:|..
Mouse  2130 EECEALCTRLAIMVKGTFQCLGTIQHLKYKFGDGY------IVTMKIKSP----------KDDLL 2178

  Fly  1586 GTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRI 1650
            ..    |....|.|...|..|..|.::            |::::        |.:.|.  .::||
Mouse  2179 PD----LNPVEQFFQGNFPGSVQRERH------------HSMLQ--------FQVPSS--SLARI 2217

  Fly  1651 VDTL--HRNKQDFYSFSVSQPSVNSVFLSIHRQKSNKDAFP 1689
            ...|  |::......:||:|.:::.||::..:|::.....|
Mouse  2218 FQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTETYDLP 2258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	120/504 (24%)
		ABC_subfamily_A	519..737	CDD:213230	63/223 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	50/189 (26%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	393/2056 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..910		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1344		6/32 (19%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000250|UniProtKB:P78363	2243..2248		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2266..2310