Protein Alignment CG43672 and Abca1

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_006537617.1
• Gene: Abca1 / 11303
• MGIID: 99607
• Length: 2263
• Species: Mus musculus
• Alignment Length: 2058
• Identity: 400/2058 - (19%)
• Similarity: 717/2058 - (34%)
• Gaps: 638/2058 - (31%)

  Fly    68 WSS----LIGKI------QERRAKMASKQRNFTTNVFIPDIR----------VAFAPNSNAA-LR 111
            |.:    |:|||      ...|..||...:.|.......|:.          ..|..||... |.
Mouse   372 WKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLV 436

  Fly   112 RLMGDALGKLSMSEDKI--VDF----------ENCNDMRIHAASEHYLASVCFRNVDES------ 158
            |.:.|:.|.....|.|:  :|:          :|..|::....|. |.....|...:::
Mouse   437 RTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSV-YTWREAFNETNQAIQTISR 500

  Fly   159 ---------LNGLPTVLNFAIIMPSELRNYEDTWIGDSWKETT-------------TLMDRDVAE 201
                     |..:||.:.. |....||.:....|.|..:...|             ..||.|..|
Mouse   501 FMECVNLNKLEPIPTEVRL-INKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVE 564

  Fly   202 EDEFDEDGYTD------------YMGEGFVPLQYHISMQFLRA-------TASKVEKLP------ 241
            .....:|||.|            |:..||..||..:....:|.       |...|:::|
Mouse   565 RTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVD 629

  Fly   242 ----KVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASA 302
                :|:.|                |:.|.:.|.:::.|.::...||.|:|...:..::|:....
Mouse   630 DIFLRVMSR----------------SMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDN 678

  Fly   303 TLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPW--PILLCFLISYGCSVTSL-IIL 364
            .:...:||.:.....|:::.|:.::||:.        |..|:  |.::...:|....||.| ..|
Mouse   679 GILWFSWFVSSLIPLLVSAGLLVVILKLG--------NLLPYSDPSVVFVFLSVFAMVTILQCFL 735

  Fly   365 MTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFA----TVLLCNVSFSRGLSKIF 425
            :::...|:.:|.....||:..|.||.     :|......:.||:    ..||..|:|..|.....
Mouse   736 ISTLFSRANLAAACGGIIYFTLYLPY-----VLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFA 795

  Fly   426 YIEDYTLGVTIGKYMFYRVSKSDFGI------------FVPIVCFYVQTIF-------------C 465
            ..|:..:||.........|.:..|.:            ...::.:|::.:|             |
Mouse   796 LFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPC 860

  Fly   466 TLLAMIFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSK--TSAEALIEFRGVWQKY 528
            |         ..:|....:..        :|..|..::.:.|:...:  |.....:..:.:.:.|
Mouse   861 T---------KSYWFGEEIDE--------KSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVY 908

  Fly   529 SNSTYVVQD-ITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIVTQRKEALK 592
            .:...|..| :.||.|.|::.:.||||.:||:|.:.:|.|...|..|..|:.|.:|.::.....:
Mouse   909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQ 973

  Fly   593 NSSISMSYKTLFTELVVLDHLVFLSRLRGLSK--TEAKLEAKAL---LRYLKLEDWEKTLVNDLT 652
            |..:...:..||..|.|.:|:.|.:||:|||:  .:|::|..||   |...||    |:..:.|:
Mouse   974 NLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKL----KSKTSQLS 1034

  Fly   653 IGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIAD 717
            .|.:|.|....||.||:::||||:|..|:|.......:.|:|..::.|:|..::::...|..:.|
Mouse  1035 GGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGD 1099

  Fly   718 RIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMAT-------------FIPE 769
            ||.::|.|||...|:...|...|...|.|.:..      |||.:.:::             .:|.
Mouse  1100 RIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVK------KDVESSLSSCRNSSSTVSCLKKVVPG 1158

  Fly   770 I-----------EMDSILA---DCASFLVKHKYHTELINLIENLA-------------------- 800
            :           |:..::|   |.::.....:.|.....|:|::.
Mouse  1159 LPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVEL 1223

  Fly   801 ------RLKNDLNVYSFEIHECSIDDILASL---------------------------------Y 826
                  || :||.:.|:.|.|.::::|...:                                 :
Mouse  1224 FHEIDDRL-SDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPF 1287

  Fly   827 TRD---------------KSTLEFGQPGLQTLLASRQQSAKRRFIIPTMYLLEELRQLLIA-DTR 875
            |.|               ::.|..|..|..:......:..:::|:.    ||  .::|||| .:|
Mouse  1288 TEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVA----LL--WKRLLIARRSR 1346

  Fly   876 NWFLPILKLTLPSLVV----VWTLSMPYF----------WHNCRQPGHITFPMS----------- 915
            ..|  ..::.||::.|    |::|.:|.|          |....|   .||..:
Mouse  1347 KGF--FAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQ---YTFVSNDAPEDMGTQEL 1406

  Fly   916 ------DHGDGIILMQKDTL-DSELLVASEMY--AKVGVTEVD---------------------- 949
                  |.|.|...|:.:.: |:..|...|.:  :.|..:.||
Mouse  1407 LNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDK 1471

  Fly   950 ----------------------KTVDITTFIYNYEYKNSLLSDADIMEAVIFSNVQI--EVLFNT 990
                                  ||.||   :.|       |:..:|.:.::.:.|||  :.|.|.
Mouse  1472 IKKMLPVCPPGAGGLPPPQRKQKTADI---LQN-------LTGRNISDYLVKTYVQIIAKSLKNK 1526

  Fly   991 KW---------------------PHTAPDSLAQA---------------LNSLA--VAFIDGDAG 1017
            .|                     .|...|::.|.               |:||.  :|.:|....
Mouse  1527 IWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNN 1591

  Fly  1018 IKV---------------------------------ELEVLPFSTIHTLQL--------HLNIDG 1041
            :||                                 :..:..|:  |.|.|        .|....
Mouse  1592 VKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFN--HPLNLTKQQLSEVALMTTS 1654

  Fly  1042 YDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELL-VVLLALFP 1105
            .|::.:.|:.|...|:.:..::.:...|..:..:::.|:|:..::..::..::::. .|:.|...
Mouse  1655 VDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLV 1719

  Fly  1106 INIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPIS---DMPFVYLKVLLAYSL- 1166
            |.|.:.|.....:..:|:.:.::.::      ::..:|...:.|.|   .:|.....||.:.:|
Mouse  1720 IIIFICFQQKSYVSSTNLPVLALLLL------LYGWSITPLMYPASFVFKIPSTAYVVLTSVNLF 1778

  Fly  1167 -GILVYIAVKELRPFTNPNT--------------AHFL----LLDFHPFYALLHNLMRIAS---I 1209
             ||...:|...|..|||...              .||.    |:|.....|:...|.|...   :
Mouse  1779 IGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFV 1843

  Fly  1210 SEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMV 1274
            |...|....|.::..:|..                         |...|:.|.|....|::...|
Mouse  1844 SPLSWDLVGRNLFAMAVEG-------------------------VVFFLITVLIQYRFFIRPRPV 1883

  Fly  1275 KRR--PRQPKYFWDSDPDSKYD-QNIL------HIMEPSELENTWIHEKSRVSTLERNHIESKAL 1330
            |.:  |..     |.|.|.:.: |.||      .|:|..||  |.|:.:.|
Mouse  1884 KAKLPPLN-----DEDEDVRRERQRILDGGGQNDILEIKEL--TKIYRRKR-------------- 1927

  Fly  1331 HVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFK 1395
                       |.|:..|...:...:...:.|.||.|||...|.:.|....:.|....:     |
Mouse  1928 -----------KPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLN-----K 1976

  Fly  1396 SKDLDSCHMV----GYSAQEFQTMQLMTILETWDL--ILRIRRSKQISFRAE--ATKLCKIFGLY 1452
            :..|.:.|.|    ||..|.....:|:|..|..:.  :||....|::....|  ..||    ||.
Mouse  1977 NSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKL----GLV 2037

  Fly  1453 KYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYT 1517
            ||.....|..|.|..::||..:||:....::.||:|.|.:|..::|.:.:....:.:.|.|::.|
Mouse  2038 KYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLT 2102

  Fly  1518 CSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEA 1580
             |.:.....||  |||.:.......:|..:.: :|.:...|.:..||
Mouse  2103 -SHSMEECEALCTRMAIMVNGRFRCLGSVQHL-KNRFGDGYTIVVRI------------------ 2147

  Fly  1581 KEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMY 1645
                ||:...|  ...|||...                   .||.:::|......:.:.|.|.:.
Mouse  2148 ----AGSNPDL--KPVQEFFGL-------------------AFPGSVLKEKHRNMLQYQLPSSLS 2187

  Fly  1646 PMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSIHRQKSNKD 1686
            .::||...|.::|:..:  .:||||.:::.||::..:.:|:.|
Mouse  2188 SLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	119/505 (24%)
		ABC_subfamily_A	519..737	CDD:213230	69/223 (31%)
		P-loop_NTPase	1330..1517	CDD:422963	47/194 (24%)
Abca1	XP_006537617.1	rim_protein	6..2238	CDD:130324	400/2058 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920