Protein Alignment CG43672 and ABCA8

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: NP_001275914.1
• Gene: ABCA8 / 10351
• HGNCID: 38
• Length: 1621
• Species: Homo sapiens
• Alignment Length: 1903
• Identity: 376/1903 - (19%)
• Similarity: 691/1903 - (36%)
• Gaps: 529/1903 - (27%)

  Fly     5 ICHVFCLLVWKNFQKQ---KHNKLVLIL-SLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLE 65
            :|.....|:.|||.|:   |...|:..| ||:|     |..|:|...| ..:.|:|     .||.
Human     8 VCQQTWALLCKNFLKKWRMKRESLMEWLNSLLL-----LLCLYIYPHS-HQVNDFS-----SLLT 61

  Fly    66 FSWSSLIGKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVD 130
            ..    :|::.           .|..:.|    .|.:.|.:|.. :::|           :|:
Human    62 MD----LGRVD-----------TFNESRF----SVVYTPVTNTT-QQIM-----------NKV-- 93

  Fly   131 FENCNDMRIHAASEHYLASVCFRNVDESLNGLP---TVLNFAIIMPSEL--RNYEDTW------- 183
                       ||..:||.       :.:.|||   ::..|....|.|:  ..:.:|:
Human    94 -----------ASTPFLAG-------KEVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFL 140

  Fly   184 IGDSWKETTTLMDRDVAEEDEFDEDGYTD---YMGEGFVPLQYHISMQFLRATA--SKVEKLPKV 243
            :|..........|. .|...|.:||.|.:   :..||||.||..|:...:..|.  |.:|:|..|
Human   141 LGHGMPAKKEHKDH-TAHCYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSV 204

  Fly   244 VMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELG---QRYMLKILNASATLQ 305
            .      ..|:.:...||.|.|:..|  ::|...|..:..:....:.   :|..:|.|.....|:
Human   205 T------GKNMKMHSFIGQSGVITDL--YLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLR 261

  Fly   306 MAAWFFN---VFTHFL-ITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMT 366
            .:|::.:   ::..|: |.:|.:.::::     :|..:....:.::....:.||.|:.:|..||:
Human   262 DSAFWLSWGLLYAGFIFIMALFLALVIR-----STQFIILSGFMVVFSLFLLYGLSLVALAFLMS 321

  Fly   367 SAMRRS---RVAMVMAPIIWILLALPLL------SKKELLSDGPDVFYGFATVLLCNVSFSRGLS 422
            ..:::|   .:.:.:..:.|..|....|      |.:.:||            ||...:|..|::
Human   322 ILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWILS------------LLSPFAFMLGMA 374

  Fly   423 KIFYIEDYTLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLAIRVKNL 487
            ::.:: ||.|......:      .||..          ..|..|...:.|:...|..|||..:.:
Human   375 QLLHL-DYDLNSNAFPH------PSDGS----------NLIVATNFMLAFDTCLYLALAIYFEKI 422

  Fly   488 L-KKYHATRSAVGRLKRQI-----------------PEVSFSKTSAEALIEFRG--------VWQ 526
            | .:|...|..:..||...                 .:.||..:..:|..||:|        |.:
Human   423 LPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTK 487

  Fly   527 KYS---NSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGE--IYLSGFNIVTQ 586
            :|.   :....::|:..::|.|::.|:|||:.:||||::.:|.|.:.|..|.  ||.:..:.:..
Human   488 EYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMAD 552

  Fly   587 RKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDL 651
            .:...|.:.:.......|..|.|.::|...::::|:...|...|.:.:|..|::::.:..|..:|
Human   553 LENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNL 617

  Fly   652 TIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIA 716
            :.||:|.|.|..|..|..||.:||:|..|:|.......::|:.::|.:|.|.|::.....|..:|
Human   618 SGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILA 682

  Fly   717 DRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDS------- 774
            ||...||:|||:..|:...|.:.....|.|.:..||.|..:::.:.:...||:.::.:
Human   683 DRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLI 747

  Fly   775 -------------ILADCASF--LVKHKYHTELINLIENLARL--KNDLNVYSF----EIHECSI 818
                         :..|..|:  |....|...:..|.|...:|  |:.:|....    |:.....
Human   748 YTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKA 812

  Fly   819 DD---------ILASLYTRDKSTLEFGQPGLQTLLASRQQSAKRRFIIPTMYLLEELRQLLIADT 874
            ||         :|:||   :|.....|...|.     |||          :..:..:|.|.:...
Human   813 DDTERLVEMEQVLSSL---NKMRKTIGGVALW-----RQQ----------ICAIARVRLLKLKHE 859

  Fly   875 RNWFLPILKLTL----PSLV-----------VVWTLSMP--YFWHNCRQPGHITFPMSDHGDGII 922
            |...|.:|.:.:    |.||           ..|.|| |  ||....:||..   |::.    ::
Human   860 RKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELS-PHLYFLAPGQQPHD---PLTQ----LL 916

  Fly   923 LMQKDTLDSELLVASEMYAKVGVTEVDK------TVD------ITTFIYNYEYKNSLLSDA---- 971
            ::.|.....:..:.|..:..:.: |||.      |.|      ||.......|..||..:|
Human   917 IINKTGASIDDFIQSVEHQNIAL-EVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLN 980

  Fly   972 ------DIMEAVIFSNVQIEVLFNTK---------------------W--------PHTAPDSL- 1000
                  ||:...:...|:..|...|:                     |        |:.|..|:
Human   981 CFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSID 1045

  Fly  1001 ---AQALNSLAV------AFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCF 1056
               .:|.:.|.:      |:..|.|.:.|.|..|.|..|:.:....|.:...|.....:......
Human  1046 DYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAV 1110

  Fly  1057 IWSIPLLHMT-----LSRDGRYNYVELIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIFFHWD 1116
            .:|..|:.||     :.|.||.|
Human  1111 GYSFSLIFMTYVISFIFRKGRKN------------------------------------------ 1133

  Fly  1117 LLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFVYLKVL-LAYSLGILVYIAVKELRPF 1180
                |.|..:..||:.:.:...|:.:|.     .||:||::..:: .|..:|.|..
Human  1134 ----SGIWSFCFYVVTVFSVAGFAFSIF-----ESDIPFIFTFLIPPATMIGCLFL--------- 1180

  Fly  1181 TNPNTAHFLL--------LDFHPFYALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNC 1237
                ::|.|.        :|..||...|                                 ||
Human  1181 ----SSHLLFSSLFSEERMDVQPFLVFL---------------------------------IP-- 1206

  Fly  1238 CDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIME 1302
                   |.|  ::..::.|..:.|         ...|:..|:..:|..|...|...||    .|
Human  1207 -------FLH--FIIFLFTLRCLEW---------KFGKKSMRKDPFFRISPRSSDVCQN----PE 1249

  Fly  1303 PSELENTWIHEKSRVSTL---------ERNHIESKALHVEHLSVFFGL------KAAIKHIDFMV 1352
            ..|.|:..: :..||.|.         |:..|.:..|..|:.....|.      |.|.:::.|.|
Human  1250 EPEGEDEDV-QMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCV 1313

  Fly  1353 NRYQVMSVFGANGTGKSVLLKTILGIYTPSSGRIISSKTVPFKSKDLDSCHMVGYSAQEFQTMQL 1417
            .:.:|:.:.|.||.|||..:|.|.|...|::|:::..     .|...|:...:||..||......
Human  1314 RKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLK-----GSGGGDALEFLGYCPQENALWPN 1373

  Fly  1418 MTILETWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAEL 1482
            :|:.:..::...::..::.......|:|.....|.....:.:...|:|:.::|...::::.:..:
Human  1374 LTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSV 1438

  Fly  1483 ILLDDPFTHLDIVSQRSMLHIIH-DLRRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIG 1542
            :|||:|.|.:|...|:.|...|. ..|......:.|   |.|...|.    |:|.:....:..||
Human  1439 VLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT---THYMAEAEAVCDRVAIMVSGRLRCIG 1500

  Fly  1543 EREEMQQNYYSSYYMVETRI-HLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDS 1606
            ..:.::.. :...|::|.:: :||:: .|:                        |.|....|..:
Human  1501 SIQHLKSK-FGKDYLLEMKVKNLAQV-EPL------------------------HAEILRLFPQA 1539

  Fly  1607 ADRWKYLKLCGV---IENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFYSFSVSQ 1668
            |.:.:|..|...   :|:|.|               |:...:.:.::     :...|...:|:||
Human  1540 ARQERYSSLMVYKLPVEDVQP---------------LAQAFFKLEKV-----KQSFDLEEYSLSQ 1584

  Fly  1669 PSVNSVFLSIHRQKSNKD 1686
            .::..|||.:.:::...|
Human  1585 STLEQVFLELSKEQELGD 1602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	111/512 (22%)
		ABC_subfamily_A	519..737	CDD:213230	63/230 (27%)
		P-loop_NTPase	1330..1517	CDD:422963	42/193 (22%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	123/588 (21%)
		ABC_subfamily_A	480..703	CDD:213230	60/222 (27%)
		rim_protein	<1033..1598	CDD:130324	135/740 (18%)
		ABC_subfamily_A	1285..1506	CDD:213230	50/228 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850