DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43672 and ABCA9

DIOPT Version :9

Sequence 1:NP_788912.3 Gene:CG43672 / 318910 FlyBaseID:FBgn0263747 Length:1690 Species:Drosophila melanogaster
Sequence 2:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens


Alignment Length:1891 Identity:350/1891 - (18%)
Similarity:695/1891 - (36%) Gaps:519/1891 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 CLLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSLIGK 74
            ||..|:   .::...|..:.|.:|.:.  |:|.|      ||:.......:...::      :|:
Human    28 CLKKWR---MKRQTLLEWLFSFLLVLF--LYLFF------SNLHQVHDTPQMSSMD------LGR 75

  Fly    75 IQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSEDKIVDFENCNDMRI 139
            :.           :|....::    :||||.|                         :...::..
Human    76 VD-----------SFNDTNYV----IAFAPES-------------------------KTTQEIMN 100

  Fly   140 HAASEHYLASVCFRNV-----DESLNGLPTVLNFAIIMPSELRNYEDTW---IGDSWKETTTLM- 195
            ..||..:|..   |.:     ::|::.|.  ||::|.....:  :.||:   :..||.....:| 
Human   101 KVASAPFLKG---RTIMGWPDEKSMDELD--LNYSIDAVRVI--FTDTFSYHLKFSWGHRIPMMK 158

  Fly   196 -DRD-----VAEEDEFDEDGYTDYMGEGFVPLQYHISMQFLRATA--SKVEKLPKVVMRRFNENP 252
             .||     .|..::...:| :::..:|||..|..|:...:....  |.:|:|..|........|
Human   159 EHRDHSAHCQAVNEKMKCEG-SEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILP 222

  Fly   253 NVLLSEGIGTS-VVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAW--FFNVF 314
            .| ...|:.|. .:...::.|...:..::..:.:||:    |:..::......:.|.|  :..::
Human   223 FV-AQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQ----YITSLMTMMGLRESAFWLSWGLMY 282

  Fly   315 THF-LITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAMRR---SRVA 375
            ..| ||.:.|:.:::|     :...|....:.::....:.||.|:.:|..||:..:::   :.:.
Human   283 AGFILIMATLMALIVK-----SAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLV 342

  Fly   376 MVMAPIIWILLALPLLSKKELLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTLGVTIGKYM 440
            :.:..:.|.:|..|.|..:      ...|..:...||...:|:.|::::.:: ||    .:....
Human   343 VFLLIVFWGILGFPALYTR------LPAFLEWTLCLLSPFAFTVGMAQLIHL-DY----DVNSNA 396

  Fly   441 FYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFEN----------------NAYFWL--------- 480
            ....|::.:.|...:......|:...:|.:.|:.                .:.||.         
Human   397 HLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVV 461

  Fly   481 --------------------------AIRVKNLLKKYHATRSAVGRLKRQIPEVSFSKTSAEALI 519
                                      |||:|||.|:|      .|:.:|           .||| 
Human   462 LENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEY------AGKCER-----------VEAL- 508

  Fly   520 EFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGEIYLSGFNIV 584
                            :.:..::|.|::.|||||:.:||:|::.:|.|.:.|..|.:.:  :|..
Human   509 ----------------KGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTV--YNHT 555

  Fly   585 TQRKEALKNSSISMSY----KTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEK 645
            ..|...::|.|....:    ...|..|.|.::|...::::|:...|.:.|.:.:::.|::|:.:.
Human   556 LSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQD 620

  Fly   646 TLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQK 710
            .|..:|:.||.|.|.|..|..|..|:::||:|..|:|.......::|:.:.|.:|.|.|::....
Human   621 ILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFID 685

  Fly   711 VASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSI 775
            .|..:|||...:|.|||:..|:...|.:.....|.|.:..||:|..:.:.:.:...|.:.::.:.
Human   686 EADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQ 750

  Fly   776 LADCASFLVKHKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTRDKSTLEFGQPG- 839
            ..:...:::..:...:...|..:|.|..|. .:..:.:...:::::...|  ..|||::....| 
Human   751 SEEKLVYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKL--EGKSTIDESDIGI 812

  Fly   840 -----------------LQTLLAS--------------RQQ---SAKRRFI-----------IPT 859
                             |:.:|:|              |||   .||.||:           |..
Human   813 WGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILL 877

  Fly   860 MYLLEELRQLLIADTRNWFLPILKLTLPSLVVVWTLS-MPYFWHNCRQPGHITFPMSDHGDGIIL 923
            ::.:..:.|||    .:.|....:.:.|     |.|| ..||....:||                
Human   878 LFGISFIPQLL----EHLFYESYQKSYP-----WELSPNTYFLSPGQQP---------------- 917

  Fly   924 MQKDTLDSELLVASEMYAKVGVTEVDKTVDITTFIYNYEYKNSLL-----------SDADIMEAV 977
              :|.| :.|||.:    |.|.|       |..|:::...:|..:           .|.....|:
Human   918 --QDPL-THLLVIN----KTGST-------IDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 968

  Fly   978 IFS----NVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLN 1038
            |.|    :.:..:..|||..:..|..|....|.|...|...:                    |:.
Human   969 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSE--------------------HIQ 1013

  Fly  1039 IDGYDLIFASCLSFCF-----CFIWSIPLL-----HMTLSRDGRYN---YVEL-IAGM-PTIV-- 1086
            .| ....|...:.:.:     .|.| ||:.     ::.:|..|.|.   :.:| |:|: |:..  
Human  1014 TD-RSTFFEEHMDYEYGYRSNTFFW-IPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWF 1076

  Fly  1087 --LIVAFLIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYS-VYVMFIIAACVFSLNILITIM 1148
              .:|...:|.|:::|:.               :||   :|:| ..::|||...:  :.||.:|.
Human  1077 GQALVDVSLYFLILLLMQ---------------IMD---YIFSPEEIIFIIQNLL--IQILCSIG 1121

  Fly  1149 PISDMPFVYLKVLLAYSLG------------ILVYIAVKELRPFTNPNTAHFLLLDFH----PFY 1197
            .:|.:.|:...:...:..|            |:|..::..    |:.|...||.|.|.    |.:
Human  1122 YVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVA----TDLNEYGFLGLFFGTMLIPPF 1182

  Fly  1198 ALLHNLMRIASISEKIWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVW 1262
            .|:.:|...:.||                             .|:.::........|||.|::.:
Human  1183 TLIGSLFIFSEIS-----------------------------PDSMDYLGASESEIVYLALLIPY 1218

  Fly  1263 ISIFIFL----------------KSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEP-SELENTW 1310
            :...|||                |..:.:..||....|  .:|:           || .|.|:..
Human  1219 LHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIF--PNPE-----------EPEGEEEDIQ 1270

  Fly  1311 IHEKSRVSTLE-RNHIESKALHVEHLSVFFG-----------LKAAIKHIDFMVNRYQVMSVFGA 1363
            :.....|:.:. |:..|:..:....|...:.           .|.|.:::.|.|.:.:|:.:.|.
Human  1271 MERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGH 1335

  Fly  1364 NGTGKSVLLKTILGIYTPSSGRIISSKTVPFKSKDLDSCHMVGYSAQEFQTMQLMTILETWDLIL 1428
            ||.|||..:|.|.|...|::|::|..     .|...:....:||..||......:|:.:..::..
Human  1336 NGAGKSTTIKMITGDTKPTAGQVILK-----GSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYA 1395

  Fly  1429 RIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLD 1493
            .::..::.......|:|.....|.......:...|:|:.::|...::::.:..::|||:|.|.:|
Human  1396 AVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMD 1460

  Fly  1494 IVSQRSMLHIIH-DLRRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIGEREEMQQNYYS 1553
            ...|:.|..:|. ..|......:.|   |.|...|.    |:|.:....:..||..:.::..:..
Human  1461 PEGQQQMWQVIRATFRNTERGALLT---THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGK 1522

  Fly  1554 SYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGV 1618
            .|.:.....:||:: .|:                        |.|....|..:|.:.::..|...
Human  1523 DYLLEMKLKNLAQM-EPL------------------------HAEILRLFPQAAQQERFSSLMVY 1562

  Fly  1619 ---IENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFYSFSVSQPSVNSVFLSIHR 1680
               :|:|.|               ||...:.:..:     :...|...:|:||.::..|||.:.:
Human  1563 KLPVEDVRP---------------LSQAFFKLEIV-----KQSFDLEEYSLSQSTLEQVFLELSK 1607

  Fly  1681 QKSNKD 1686
            ::...|
Human  1608 EQELGD 1613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43672NP_788912.3 rim_protein <266..>732 CDD:130324 104/526 (20%)
ABC_subfamily_A 519..737 CDD:213230 56/221 (25%)
P-loop_NTPase 1330..1517 CDD:422963 40/198 (20%)
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:315386 73/443 (16%)
AAA <245..1609 CDD:333001 299/1602 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148303
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

Return to query results.
Submit another query.