DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and ABCA10

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	1637	Identity:	338/1637 - (20%)
Similarity:	633/1637 - (38%)	Gaps:	328/1637 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 VAEEDEFDEDGY----------TDYMGEGFVPLQYHISMQFLRATA--SKVEKLPKVVMRRFNEN 251
            :.|..|:.|..:          ..|..:|||..|..|:...:..|.  |.:|:|..|:.......
Human    59 IKEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIP 123

  Fly   252 PNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAW------- 309
            |.:...|.:........|:.|...:...:..:..||  |:  ..|::......:.|.|
Human   124 PFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARER--GK--FKKLMTVMGLRESAFWLSWGLTY 184

  Fly   310 -----FFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSLIILMTSAM 369
                 ..::|...:|||:.|              |....:.::......||.|:.:|..||:..:
Human   185 ICFIFIMSIFMALVITSIPI--------------VFHTGFMVIFTLYSLYGLSLIALAFLMSVLI 235

  Fly   370 RRSRVAMV---MAPIIWILLALPLLSKKELLSDGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYT 431
            |:..:|.:   :..:.|..|...:|.::..||      .|:...||...:|:.|:::|.::::|.
Human   236 RKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLS------LGWVLSLLSPFAFTAGMAQITHLDNYL 294

  Fly   432 LGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFEN----------------NAYFWL 480
            .||     :|...|...:.:..........|:|..:..:.||.                .:.||
Human   295 SGV-----IFPDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFW- 353

  Fly   481 AIRVKNLLKKYHATRSAVGRLKRQI-PE----VSFSKTSAE----ALIEFRGVWQKYSNST---Y 533
                    .|:..|...:  .:.:| ||    .||...|.|    ..|..|.|.::|:..|   .
Human   354 --------SKHQNTHHEI--FENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVE 408

  Fly   534 VVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLGE--IYLSGFNIVTQRKEALKNSSI 596
            .:|.|..::|.|::.|:||||.:||||::.:|.|.:....|.  ||.:..:.:|..:|..||...
Human   409 ALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGF 473

  Fly   597 SMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQRRVLQF 661
            ...:...|..|.|.::|...::::|:...|.:.|.|.::..|.::..:..:...|:.||:|.|..
Human   474 CPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTL 538

  Fly   662 LCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIFVLSKGK 726
            ..|..|..|:::||:|..|:|.......:||:.:.|.:|.|.|::.....|..:|||...||.||
Human   539 GIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGK 603

  Fly   727 LQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIEMDSILADCASFLVKHKYHTE 791
            |:..|:...|.|.....|.|.:..||.|..:.:.:.:...||:.::.:...:...:.:..:...:
Human   604 LKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK 668

  Fly   792 LINLIENLARLKNDLNVYSFEIHECSIDDILASLYTR---DKSTLEFG-------------QPGL 840
            ..:|..:|.:. :|..:.::.:...|::::..:|..:   |:...:.|             :..:
Human   669 FPDLYSDLDKC-SDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEM 732

  Fly   841 QTLLASRQQSAK--------RR--FIIPTMYLLE---ELRQLL-------IADTRNWFLPIL--- 882
            :.:|.|..::.|        ||  :.:.|:..|:   |.|.||       ||     |:||:
Human   733 EQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIA-----FIPIILEK 792

  Fly   883 ---KLTLPSLVVVWTLSMPYFWHNCRQPGHITFPMSDHGDGIILMQKDTLDSELLVASEMYAKVG 944
               |:|..:  ..|..|...::.:..|                 :.|..|.|.|:|.:.......
Human   793 IMYKVTRET--HCWEFSPSMYFLSLEQ-----------------IPKTPLTSLLIVNNTGSNIED 838

  Fly   945 VTEVDKTVDITTFIYNYEYKNSLLSDADIMEAVIFSNVQIEVLF----NTKWPHTAPDSLAQALN 1005
            :....|..||...|.::..:|. ..|.....|:|.|..|.:..|    |||..:..|..:....|
Human   839 LVHSLKCQDIVLEIDDFRNRNG-SDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSN 902

  Fly  1006 SLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLN-IDG--YDLIFASCLSFCFCFIWSIPLLHMTL 1067
            :|...|...:.   :::|...||. ..:.|.|. |||  :.|:..:|:|         |.:.|:.
Human   903 ALMGIFNFTEL---IQMESTSFSR-DDIVLDLGFIDGSIFLLLITNCVS---------PFIGMSS 954

  Fly  1068 SRDGRYNYVE--LIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIF------FHWDLLMDSNIH 1124
            ..|.:.|...  .|:|:..........:.::.:..|.||.|::...|      ..|:|
Human   955 ISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWEL------- 1012

  Fly  1125 IYSVYVMFIIAACVFSLNILITIMPISDMPFVYLKVLLAY------------SLG-ILVYIAVKE 1176
                  ||::..|:....:.:          ::|..:|::            |.| .::.|.|..
Human  1013 ------MFVLVVCIIGCAVSL----------IFLTYVLSFIFRKWRKNNGFWSFGFFIILICVST 1061

  Fly  1177 LRPFTNPNTAHFLL-LDFHPFYALLHNLMRIASISEKIWLCS-DRQIYETSVYADQCNTIPNCCD 1239
            :...|.....:.:| :.|.|.:.||..:|.:..:.....|.| |.:|.|.:........||
Human  1062 IMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIP---- 1122

  Fly  1240 DDAQEFYHLRYLCCVYLLLVVVWISI----FIFLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHI 1300
                      ||..|..|.|:..:.:    .|..|..:.:..||..:...:.:...:.|:::
Human  1123 ----------YLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDV--- 1174

  Fly  1301 MEPSELENTWIHEKSRVSTLERNH-IESKALHVEHL----SVFF--GLKAAIKHIDFMVNRYQVM 1358
                :.|............||... |.:..||.|:.    |.|.  ..|.||:::.|.|.:.:|:
Human  1175 ----QAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVL 1235

  Fly  1359 SVFGANGTGKSVLLKTILGIYTPSSGRII-SSKTVPFKSKDLDSCHMVGYSAQEFQTMQLMTILE 1422
            .:.|.||.|||..:|.|.|...|::|.:: .......:.:..:|...:||..||......:|:.|
Human  1236 GLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKE 1300

  Fly  1423 TWDLILRIRRSKQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDD 1487
            ..:|...::...:.......::|.:...|.:.....:...|:|:.::|...::::.:..::|||:
Human  1301 HLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDE 1365

  Fly  1488 PFTHLDIVSQRSMLHIIHDL---RRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIGERE 1545
            |||.:|...|:.|..|:...   :.||     |...|.|.:.|.    |||.:....:..||..:
Human  1366 PFTGMDPEGQQQMWQILQATVKNKERG-----TLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQ 1425

  Fly  1546 EMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRW 1610
            .: :|.:...|::|.::                  ||.      |.:...|.|....|..:|.:.
Human  1426 HL-KNKFGRDYLLEIKM------------------KEP------TQVEALHTEILKLFPQAAWQE 1465

  Fly  1611 KYLKLCGV---IENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDF--YSFSVSQPS 1670
            :|..|...   :|:|                      :|:||....|...||.|  ..:|:||.:
Human  1466 RYSSLMAYKLPVEDV----------------------HPLSRAFFKLEAMKQTFNLEEYSLSQAT 1508

  Fly  1671 VNSVFLSIHRQK 1682
            :..|||.:.:::
Human  1509 LEQVFLELCKEQ 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	117/510 (23%)
		ABC_subfamily_A	519..737	CDD:213230	65/222 (29%)
		P-loop_NTPase	1330..1517	CDD:422963	47/196 (24%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	338/1635 (21%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177		3/30 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920