Protein Alignment CG43672 and abca1

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_004910916.1
• Gene: abca1 / 100491942
• XenbaseID: XB-GENE-1001143
• Length: 2311
• Species: Xenopus tropicalis
• Alignment Length: 1902
• Identity: 365/1902 - (19%)
• Similarity: 674/1902 - (35%)
• Gaps: 541/1902 - (28%)

  Fly   175 ELRNYEDTWIG----DSWKETTTL---------MDRDVAEEDEFDEDGYTD------------YM 214
            ||.|....|.|    |..:|.|.|         ||.|..|.....:|||.|            |:
 Frog   529 ELLNERKFWAGIVFMDMPEEETELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYI 593

  Fly   215 GEGFVPLQYHISMQFLRATASKVEKLPKVVMRRFNENPNVLLSEGI-----GTSVVLLILLGFMF 274
            ..||..||..:....:|.... |||...:.:::.   |.....:.|     ..|:.|.:.|.:::
 Frog   594 WGGFSYLQDVVEQAIIRVQTG-VEKRTGIYVQQM---PYPCYVDDIFLRVMSRSMPLFMTLAWIY 654

  Fly   275 PVTILTTLIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAV 339
            .|.::...||.|:|...:..::|:.....:...:||.:.....|:::.|:.::||        ..
 Frog   655 SVAVIIKGIVYEKEARLKETMRIMGLDNGILWLSWFISSLIPLLMSAALLVLILK--------TG 711

  Fly   340 NKCPW---PILLCFLISYGCSVTSLIILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLS 398
            |..|:   .::..||..:.....|...|:::...|:.:|.....||:..|.||   .::.::.:.
 Frog   712 NLLPYSDPSVVFVFLSVFAVVTISQCFLISTIFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVG 776

  Fly   399 DGPDVFYGFATVLLCNVSFSRGLSKIFYIEDYTLGVTIGKYM-------FYRVSKSDF-----GI 451
            ....:|..|    |..|:|..|......:|:..:||.....:       .|.::.|.|     .:
 Frog   777 YTLKIFASF----LSPVAFGFGCEVFALLEEQGVGVQWDNLLESPLEENGYNITTSGFMMLFDTL 837

  Fly   452 FVPIVCFYVQTIFCTLLAM----IFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVSFSK 512
            ...|:.:|::.:|.....:    .|.....:|..    ...|:|:...:.             .|
 Frog   838 LYGIMTWYIEAVFPGQYGIPRPWYFPFTKSYWCG----EECKEYNQPHTV-------------QK 885

  Fly   513 TSAEALIE-----------FRGVWQKYSNSTYVVQD-ITLNVYAGEVVALLGHNASGKSTIIKML 565
            .|:|..:|           .:.:.:.|.|...|..| :|||.|.|::.:.||||.:||:|.:.:|
 Frog   886 GSSEVCMEEEPSHLPLGVSIQNLVKIYRNGKKVAVDGLTLNFYEGQITSFLGHNGAGKTTTMSIL 950

  Fly   566 YGRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLE 630
            .|...|..|..|:...:|.|:.....:|..:...:..||..|.|.:|:.|.:||:|||:.:.|.|
 Frog   951 TGLFPPTTGTAYIMKKDIRTELNSIRQNLGVCPQHNVLFDALTVEEHIWFYARLKGLSEEKVKAE 1015

  Fly   631 AKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILD 695
            .:.::..:.|...:|...:.|:.|.:|.|....||.||:::||||:|..|:|.......:.|::.
 Frog  1016 MEQMVNDVGLPHKKKYKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLIK 1080

  Fly   696 QKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEK----CSF 756
            .::.|:|..::::...|..:.|||.::|.|||...|:...|...|...|.|.:...:.    .|.
 Frog  1081 YRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKRDNDSSLSSC 1145

  Fly   757 KDVYAFMATF--------------IPEIEMDSILADCASFLVKHKYHT----------------- 790
            ::..:.|:..              .|.|...|.....|:.:.||..||
 Frog  1146 RNSSSTMSYLKKESSKQTACKQHPSPMIAAPSASGTTAAVITKHSKHTAGQKKEAKDREDSVSQS 1210

  Fly   791 -------------------ELINLIENL-------ARLKNDLN-----VYSFE----------IH 814
                               ..::.|.||       |||..|:.     |..:|          .|
 Frog  1211 SSDAGLGSDHESDTMTIGLTDVSAISNLINKHVPEARLVEDIGHELTYVLPYEAAKEGAFVELFH 1275

  Fly   815 ECSIDDILASL----YTRDKSTLE------FGQPGLQ------TLLASRQ-------QSAKRRFI 856
            |  |||.|:.|    |....:|||      ....|:.      ||.|.|:       ||..|.|.
 Frog  1276 E--IDDRLSDLGISSYGIADTTLEEIFLKVADDTGVDAETSDGTLPARRKRYAFGDHQSCLRPFT 1338

  Fly   857 --------------------------------IPTMYLLEE------LRQLLIAD-TRNWFLPIL 882
                                            :.:..|:.:      .::||.|. :|..|  ..
 Frog  1339 EDDAFDTNDSDMDPESRETDYLSGIDGKGSYQLKSWNLMRQQFTALLWKRLLYAKRSRKGF--FA 1401

  Fly   883 KLTLPSLVV----VWTLSMPYF----------WHNCRQ------------------------PGH 909
            ::.||::.|    |::|.:|.|          |....|                        ||.
 Frog  1402 QIVLPAVFVLIALVFSLIVPPFGKYPSLELEPWMYDEQYTFFSNDAPDDQGTQALLKALIDKPGF 1466

  Fly   910 ITFPMSDH--------------------------------------------------------- 917
            .|..|..|
 Frog  1467 GTACMEGHSVMKVSCSGEEEEWSTQFVSQSVMDLFLNGNWTMENPSPSCECSSDKRKKMLPICPP 1531

  Fly   918 -GDGIILMQKDTLDSELLV------ASEMYAKVGVTEVDKTVDITTFIYNYEY-------KNS-- 966
             ..|:...|:....|::|.      .|:...|.....::|::....::..:.|       .||
 Frog  1532 GAGGLPPFQRRQNTSDILQNLTGRNISDYLVKTYSQIIEKSLKNKIWVNEFRYGGFSLGASNSPA 1596

  Fly   967 LLSDADIMEAV----------------------------IFSNVQIEVLFNTKWPHTAPDSLAQA 1003
            |..:.:::.::                            :.:...::|.||.|..| |..:....
 Frog  1597 LPPNEEVVASINHIKKRLELPQNGAANRFLDSFGAFMKGLDTKDNVKVWFNNKGWH-AVGAFLNV 1660

  Fly  1004 LNS--LAVAFIDGD----AGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPL 1062
            :|:  |.....:|:    .||......|..:.....::.|.....|::.:.|:.|...|:.:..:
 Frog  1661 MNNAILRSKLREGEDPASYGITAFNHPLNLTKEQLSEVALMTTSVDVLVSICVIFAMSFVPASFV 1725

  Fly  1063 LHMTLSRDGRYNYVELIAGMPTIVLIVAFLIYELL-VVLLALFPINIAVIFFHWDLLMDSNIHIY 1126
            :.:...|..:..:::.|:|:..::..:|..::::. .|:.|...|.|.:.|.....:..||:.:.
 Frog  1726 VFLIQERVSKAKHMQCISGVKPVIYWLANFVWDMCNYVVPATLVIIIFICFQQDSYVSSSNLPVL 1790

  Fly  1127 SVYVMFIIAACVFSLNILITIMPIS---DMPFVYLKVLLAYSL--GILVYIAVKELRPFTNPNTA 1186
            ::.::      ::..:|...:.|.|   .:|.....||.:.:|  ||...:|...|..|||...:
 Frog  1791 ALLLL------LYGWSITPLMYPASFIFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLS 1849

  Fly  1187 --------------HFL----LLDFHPFYALLHNLMRIAS---ISEKIWLCSDRQIYETSVYADQ 1230
                          ||.    |:|.....|:...|.|...   :|...|....|.::..:|..
 Frog  1850 NINEILKSVLLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPMSWDLVGRNLFAMAVEG-- 1912

  Fly  1231 CNTIPNCCDDDAQEFYHLRYLCCVYLLLVVVWISIFIFLK-SHMVKRRPRQPKYFWDSDPDSKYD 1294
                                         ||:.:|.:.:: ...:|.||...|.    .|....|
 Frog  1913 -----------------------------VVFFAITLMIQYRFFIKPRPVNAKL----PPVVDED 1944

  Fly  1295 QNILHIMEPSELENTWIHEKSRVSTLERNHIESKALHVEHLSVFFGL--KAAIKHIDFMVNRYQV 1357
            :::             ..|:.|::...||.|    |.::.|:..:.:  |.|:..:...:...:.
 Frog  1945 EDV-------------ARERQRINEGGRNDI----LELKGLTKIYRMKRKPAVDRLCVGIPPGEC 1992

  Fly  1358 MSVFGANGTGKSVLLKTILGIYTPSSGR-IISSKTVPFKSKDLDSCHM-VGYSAQEFQTMQLMTI 1420
            ..:.|.||.||:...|.:.|....::|. .:.:.::   .:::...|. :||..|.....:|:|.
 Frog  1993 FGLLGVNGAGKTTTFKMLTGDTDVTAGEAFLKNHSI---LRNIHEVHQNMGYCPQFDAINELLTG 2054

  Fly  1421 LETWDLILRIRRSKQISFRAEATKLCKI-------FGLYKYRFNSLSICSQGVLKRLSLGIALMS 1478
            .|..:|...:|...:       .::||:       .||.||........|.|..::||..|||:.
 Frog  2055 REHLELYALLRGVPE-------KEVCKVAEWAIRKLGLVKYSEKHAGNYSGGNKRKLSTAIALIG 2112

  Fly  1479 DAELILLDDPFTHLDIVSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVI 1541
            ...::.||:|.|.:|..::|.:.:....:.:.|.|::.| |.:.....||  |||.:.......:
 Frog  2113 GPPVVFLDEPTTGMDPKARRFLWNCALSVIKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFKCL 2176

  Fly  1542 GEREEMQQNYYSSYYMVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDS 1606
            |..:.: :|.:...|.:..||    .||..|                   |:...:.||.|
 Frog  2177 GSVQHL-KNRFGDGYTIIVRI----AGSNPD-------------------LKPVEEFFSHA---- 2213

  Fly  1607 ADRWKYLKLCGVIENVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY--SFSVSQP 1669
                            ||.:::|......:.:.|.|....::||...|.:||:..:  .:||||.
 Frog  2214 ----------------FPGSVLKEKHRSMLQYQLRSSQSSLARIFSILSKNKKRLHIEDYSVSQT 2262

  Fly  1670 SVNSVFLSIHRQKSNKD 1686
            :::.||::..:.:|:.|
 Frog  2263 TLDQVFVNFAKDQSDDD 2279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	115/499 (23%)
		ABC_subfamily_A	519..737	CDD:213230	67/229 (29%)
		P-loop_NTPase	1330..1517	CDD:422963	42/197 (21%)
abca1	XP_004910916.1	rim_protein	1..2272	CDD:130324	363/1893 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010