Protein Alignment CG43672 and abca3

DIOPT Version :10

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_004918068.1
• Gene: abca3 / 100490925
• XenbaseID: XB-GENE-1010698
• Length: 1720
• Species: Xenopus tropicalis
• Alignment Length: 1936
• Identity: 421/1936 - (21%)
• Similarity: 724/1936 - (37%)
• Gaps: 509/1936 - (26%)

  Fly    11 LLVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSLIGKI 75
            ||:|||:..||...||.::.|.||::.|..|:.:|....|             :.:..::|.
 Frog    25 LLLWKNYILQKRQVLVTVIELALPLLFSAILIALRHRVPS-------------VTYPNATLY--- 73

  Fly    76 QERRAKMASKQRNFTTNVFIPDIR---VAFAPNSNAALRRLMGDALGKL------------SMSE 125
                     ::..|....|||..|   :|:.|:.:.|...::.|....|            ..:|
 Frog    74 ---------REMPFPNLPFIPGPRPWELAYVPSHSKAAHSIILDVGNHLFPYYFANQSARGFPTE 129

  Fly   126 DKIVDFENCNDMRIHAASEHYLASVCF-RNVDESLNGLPTVLNFAIIMPSELRN---YEDTWIGD 186
            :   |||:.  :|.:..|...||:|.| .|.:.|.:.||..:.:.:......||   .|.|.:..
 Frog   130 E---DFEDY--IRHNNHSSKILAAVVFEHNFNHSGDPLPLQVRYRLRFKYSPRNAPMSEQTGLNP 189

  Fly   187 SWKETTTLMDRD------------VAEEDEFDEDGYT-DYMGEGFVPLQYHISMQFLRATASKVE 238
            :       :||:            ....:..|:.|.| .|..|||:.:|:.:....:|..|::..
 Frog   190 N-------VDRNWHTRYLYPLFQMPGPREAGDKTGGTPGYQREGFLAMQHEVDRAIMRYHANESG 247

  Fly   239 KL----PKVVMRRFNENP--NVLLSEGIGTSVVLLILLGFMF-PVTILTTLIVEERELGQRYMLK 296
            :|    ..|.:|||...|  |.|....|...:.||::|.|.: .::|:..|::|:....:.|| :
 Frog   248 RLLLDNIDVAIRRFPYPPYVNDLFILAIQNQLPLLLMLSFTYTSLSIVRALVLEKERKLKEYM-R 311

  Fly   297 ILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWPILLCFLISYGCSVTSL 361
            ::..|:.|...|||.:.|...|::...:|:||.|:.:...|.:.:....::..:::.:..|..|.
 Frog   312 VMGLSSWLHSTAWFIHFFLLLLVSVFFVTLLLCIQVSSEGAVLTRSDPSLVFVYILVFSVSTISF 376

  Fly   362 IILMTSAMRRSRVAMVMAPIIWILLALP---LLSKKELLSDGPDVFYGFATVLLCNVSFSRGLSK 423
            ..:::|...|:.:|......::.|..:|   :....:.|:.|..|    ::.|..||..:.|...
 Frog   377 SFMISSFFSRANMAAAAGGFLYFLSYIPYFFISPWYDELNHGAKV----SSCLFSNVGMAMGAQL 437

  Fly   424 IFYIE-------------------DYTLG-------------VTIGKYMFYRVSKSDFGIFVPIV 456
            |...|                   ::|||             ..:|.|: ..|...|:|:..|..
 Frog   438 IGMFEGKGTGAQWSNLFTPVSVDDNFTLGQVLQMLMLDCVLYFLVGWYV-ESVMPGDYGVPQPWY 501

  Fly   457 CFYVQTIFCTLLAMI--------------------FENNAYFWLAIRVKNLLKKYHATRSAVGRL 501
            ..::.:.:|....::                    .|..:.....||:|:|.|.|||:.
 Frog   502 FCFLPSYWCGTPRLVEGLEKEDDEDPEKALKGEYLEEEPSDLVPGIRIKHLTKVYHASG------ 560

  Fly   502 KRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLY 566
            |::|                            .|:|:|||:|.|:|..|||||.:||||.:.||.
 Frog   561 KKRI----------------------------AVRDLTLNMYEGQVTVLLGHNGAGKSTTLSMLT 597

  Fly   567 GRTRPKLGEIYLSGFNIVTQRKEALKNSSISM--SYKTLFTELVVLDHLVFLSRLRGLSKTEAKL 629
            |.:.|..||.|:.|:.|.  |..||...|:.:  .:..||..|.|.:||.|.:.|:|..:.....
 Frog   598 GLSPPSSGECYIGGYEIT--RDTALIRRSLGLCPQHDVLFQGLTVEEHLYFYAGLKGCPRWCCPE 660

  Fly   630 EAKALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLIL 694
            |.:.:|:.|:||:....|...|:.|..|.|....|..||:::|:||:|..|:|.......:.|:.
 Frog   661 EVEKILQILRLEEKRNALSTQLSGGTCRKLSIGIALIGGSKVVMLDEPTSGMDPASRRDTWELLR 725

  Fly   695 DQKKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDV 759
            ..|.:|::..|::....|..:.|||.:|::|:||..|:...|.......|.:::.....|..:|:
 Frog   726 QHKHDRTLLLTTHFMDEADILGDRIAILAQGQLQCCGSPLFLKCKYGAGYHMVMVKEPHCQVEDI 790

  Fly   760 YAFMATFIPEIEMDSIL-ADCASFLVKHKYHTELINLIENLARLKNDLNVYSF--------EI-- 813
            ...:.:::|...::|.. |:.:..|.|...| ....|...|...:.:|.:.|:        |:
 Frog   791 THLITSYVPNATLESNAGAELSYILPKESTH-RFEPLFSELELRREELGIASYGASVTTMEEVFL 854

  Fly   814 -----------------------HE-----------CSIDDIL---ASLYTRDKSTLEFGQPGLQ 841
                                   ||           ||:.|..   .:|.|.|.|.::..  |..
 Frog   855 RVGKLVDTSLDIQAIQLPPLQYQHERRANDWGTEESCSMSDCTEDSGTLITEDCSNIKLN--GKC 917

  Fly   842 TLLASRQQSAKRRFIIPTMYLLEELRQLLIADTRNW------FLPILKLTLPSLVVVWT------ 894
            ||..   |.....|:....|           ..|||      ||..|..|..:|||..|
 Frog   918 TLWC---QQFYALFVKRAAY-----------SWRNWKMVVGQFLVPLVFTTLALVVGKTFPGPQD 968

  Fly   895 -----LSM-PYFWHNCRQPGHITFPMSDHGDGIILMQK--------------------DTLDSEL 933
                 ||: ||        |:...|.|...:...|:|.                    |.||:.|
 Frog   969 SPPLDLSLVPY--------GYTVVPYSLPPNASTLLQSLADNFRDQFSGQQMEPQEVLDDLDNYL 1025

  Fly   934 LV-ASEMYAKVGVTEVDKTVDITTFIYNYEYKNSLLSDADIMEAVIFSNVQIEVLFNTKWPHTAP 997
            |. ||:..|.                    :....|..|||..  :.|.:::...||.:..|...
 Frog  1026 LTRASDEGAL--------------------FAERCLCAADIQN--LGSRIKVTARFNNQAYHAVA 1068

  Fly   998 DSLAQALNSLAVAFIDGDAGIKVELEVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPL 1062
            .:||...|:|.......:|.|.|.....|.:|..|.|..| ::| ...||..::    .::.:..
 Frog  1069 SALALVDNALFKLIAGPEASISVTNYPQPRNTTETAQDQL-LEG-QAGFAIAIN----LLYGMAS 1127

  Fly  1063 LHMTLS------RDGRYNYVELIAG-------------------MPTIVLIVAFLIYEL------ 1096
            |..|.|      |..:..:|:.::|                   :|...::..|..:::
 Frog  1128 LASTFSLLLVGERAVKSKHVQFVSGASALSYWLSALTWDLLNFLIPCTFMLAVFQAFDVRAYTEE 1192

  Fly  1097 -----LVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFV 1156
                 ::::|.|:...:..:.:.:..|..|....|:...:|.|.:...|. :.:|||.|..:..|
 Frog  1193 HHLVDVILMLLLYGWAVIPLMYLFSFLFTSTATAYTRLTIFNILSGTASF-LSVTIMSIPALGLV 1256

  Fly  1157 YLK--------VLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPFYALLHNLMRIASISEKI 1213
            .|.        ||..|.||          |.|:          ||:..|.||           |.
 Frog  1257 DLSHILDQVFLVLPNYCLG----------RSFS----------DFYQNYHLL-----------KF 1290

  Fly  1214 WLCSDRQIYETSVYADQCNTIPNCCDDD--------------AQEFYHLRYLCCVYLLLVVVWIS 1264
            ...|.|.       |..|......|.|:              |.......:||.::::...::..
 Frog  1291 CRSSPRS-------AIICQAFNITCQDNYFSWSSPGVGRYLTAMAVQGSAFLCLLFIIESQIFCR 1348

  Fly  1265 IFIFLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKSRVSTLERNHIESKA 1329
            ::...:|:...|        |.|.|:|.       :..|.:.:.....:|...|.||:....|..
 Frog  1349 LYNLCRSYKEHR--------WASLPESP-------VSPPEDRDVADERKKVLESPLEQLSALSSP 1398

  Fly  1330 LHVEHLSVFFGLKA---AIKHIDFMVNRYQVMSVFGANGTGKSVLLKTILGIYTPSSG-RIISSK 1390
            |.:..||..:|.:|   |:..|...|.|.:...:.|.||.||:...:.:.|..|.||| ..|...
 Frog  1399 LVIRELSKVYGRRALVLAVDRISLAVGRGECFGLLGFNGAGKTTTFRMLTGDETVSSGDAYIDGY 1463

  Fly  1391 TVPFKSKDLDSCHMVGYSAQEFQTMQLMTILETWDLILRIR-------------RSKQISFRAEA 1442
            ::....|.:.  ..:||..|....:..||..||..:..|:|             ..:.:...|.|
 Frog  1464 SILRHIKKVQ--QRIGYCPQFDPLLDHMTGRETLCMYARLRGVPEGYINSCVENMLRGLLLEAHA 1526

  Fly  1443 TKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHIIHDL 1507
            .||.:.:             |.|..::||.||||:....:|.:|:|.|.:|.|::|.:...:...
 Frog  1527 NKLVRTY-------------SGGNKRKLSAGIALIGGPSVIFMDEPSTGMDPVARRLLWDAVTRT 1578

  Fly  1508 RRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAELGSP 1570
            |..|.::|.| |.:.....||  |:|.:....:..:|..:.::..:.|.|.::
 Frog  1579 RENGKAVIIT-SHSMEECEALCTRLAIMVNGQLKCLGSPQHLKNKFGSGYTLL------------ 1630

  Fly  1571 IDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVSFPR 1635
                     ||..|..           |...||.|            .:|.:||.:::|:.....
 Frog  1631 ---------AKTSRGA-----------EELMAFKD------------FVETIFPGSVLKHEHQGM 1663

  Fly  1636 VCFWLSSHMYPMSRIVDTLHRNKQ--DFYSFSVSQPSVNSVFLSI-HRQKS 1683
            |.:.::|.....:::..||.:.|:  |...:.|||.|:..||||. |.|:|
 Frog  1664 VHYHITSQELSWAQVFGTLEKAKEKFDLEDYCVSQISLEQVFLSFSHFQQS 1714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	128/523 (24%)
		ABC_subfamily_A	519..737	CDD:213230	71/219 (32%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	52/203 (26%)
abca3	XP_004918068.1	rim_protein	17..>90	CDD:130324	22/89 (25%)
		rim_protein	<147..1712	CDD:130324	385/1780 (22%)