DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43672 and abca5

DIOPT Version :9

Sequence 1:	NP_788912.3	Gene:	CG43672 / 318910	FlyBaseID:	FBgn0263747	Length:	1690	Species:	Drosophila melanogaster
Sequence 2:	XP_005156458.1	Gene:	abca5 / 100151075	ZFINID:	ZDB-GENE-050517-5	Length:	1673	Species:	Danio rerio

Alignment Length:	1895	Identity:	378/1895 - (19%)
Similarity:	686/1895 - (36%)	Gaps:	511/1895 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWSSLIGKIQ 76
            |::||...:...|...:..|:||:: .|.||.:.|:.:.::...||..:.  |||
Zfish    37 LLYKNLLIKWRTKQQSLQELILPLL-LLGLLILISTLNPHVSYGSISTKE--LEF---------- 88

  Fly    77 ERRAKMASKQRNFTTNVFIPDIRVAFAPNSNAALRRLMGDALGKLSMSE-----DKIVDFENCND 136
            ||.               :|...:.:.|.:|.. ..:|.:...:|||:|     ....|.||.:.
Zfish    89 ERE---------------LPVKGLGYTPITNFT-NHIMEEVARELSMNEHLDMFSTEADLENASL 137

  Fly   137 MRIHAASEHYLASVCFRNVDESL----NGLPTVLNFAIIMPSELRNYEDTWIGDSWKETTTLMDR 197
            ..    .|.|:..|...::...|    :.||...:|...:.|...||.:....:.|
Zfish   138 YE----PEGYVGVVFLDSMSYRLRFPYSQLPLPSDFTESITSCYTNYVNCRAANYW--------- 189

  Fly   198 DVAEEDEFDEDGYTDYMGEGFVPLQYHISMQFLRATASKVE----KLPKVVM--------RRFNE 250
                        |:     ||:.||..|....::....:..    |:..|:|        ::|
Zfish   190 ------------YS-----GFIRLQSVIDAAIIQMKTKRPVWNELKVRAVMMGHPGSVEVQKF-- 235

  Fly   251 NPNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNASATLQMAAWF-FNVF 314
             |:.|:|        :.::|.|...|:.|...:..|:|  || :...:........|.|. :.:.
Zfish   236 -PHALIS--------IYLVLAFTPFVSFLIVNVAAEKE--QR-LKDTMGMMGLYDSAFWLSWGLL 288

  Fly   315 THFLITSLLITILLKIEWNGATAAVNKCPWPI----------LLCFLISYGCSVTSLIILMTSAM 369
            ...|:|::.|.:          |.:..|. |:          ||.||  ||.|......::|...
Zfish   289 YAALVTTMSILM----------AVIATCT-PLFSNSNFFVIFLLIFL--YGISSIFFSFMLTPLF 340

  Fly   370 RRSRVAMVMAPIIWILL-ALPLLSKKELLSDGPDVFYGFATVLLCNVS---FSRGLSKIFYIEDY 430
            ::.:.|..:..::.::. .|.|.:  .|:.|.|.    .|..|||.:|   ||.|::::.|:|..
Zfish   341 KKPKFASTVGSMLTVVFGCLSLFT--VLMRDFPQ----SAVWLLCLLSPSAFSIGIAQVVYLEAQ 399

  Fly   431 TLGVTIGKYMFYRVSKSDFGIFVPIVCFYVQTIFCTLLAMIFENNAYFWLAIRVKNLLKKYHATR 495
            ..|.     :|..:......::||:|..::..|.            |..|||.:..:|.....|:
Zfish   400 GDGA-----VFSSLGNGPHALYVPLVMLFLDCIL------------YLLLAIYLDQVLPGEFGTK 447

  Fly   496 SAV----------GRLKRQIPEVS-----------FSKTSAEALI-EFRG-----------VWQK 527
            .:|          .|.||.: |||           ....|.||:. ||||           ::::
Zfish   448 RSVLYFLKPSYWSKRRKRYV-EVSSVYEGEVNGTPAIDESVEAVSPEFRGKEVIRICNIRKIYRE 511

  Fly   528 YSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRPKLG--EIYLSGFNIVTQRKEA 590
            .......::.:|.::|.|::.|||||:.:||||::.:|.|...|..|  .||.|....:.:..|.
Zfish   512 KDTKVEALRGLTFDIYEGQITALLGHSGAGKSTLMNILCGICPPTEGTATIYGSPVAEIAEGAEM 576

  Fly   591 LKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEAKALLRYLKLEDWEKTLVNDLTIGQ 655
            .:...|...:..:|..|.|.:||...:.::|:..::...|.:.:|:.|.||.....|..:|:.||
Zfish   577 KQLVGICPQFNIIFDVLTVEEHLRIFAAIKGILPSDIDGEVRKVLKDLDLEKIMDALAKNLSGGQ 641

  Fly   656 RRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQKKNRSIFFTSNNQKVASGIADRIF 720
            :|.|....|..|..:|::||:|..|:|.......:||:..::..|....:::....|..:|||..
Zfish   642 KRKLSVGIAILGDPKILLLDEPTAGMDPVSRHQVWSLLKSRRAGRVTVLSTHYMDEADILADRKA 706

  Fly   721 VLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYAFMATFIPEIE-------------- 771
            |:|:|:|:..|:...|.......|.|.:...|.|..:.:.:.:...:|:.:
Zfish   707 VISQGQLKCVGSSLYLKTKCGVGYHLRMSVTEGCEVEGITSLVKQHVPKAQLSRQQEAELTFTLP 771

  Fly   772 ---MDSILA-----DCASFLVKHKYHTELINLIENLARLKNDLNVYSFEIHECSIDDILASLYTR 828
               ||:...     ||...|....|...:..|.:...||:          .|..:|....|::.:
Zfish   772 FESMDTFPGLFAELDCRPDLGIINYGVSMTTLEDVFLRLE----------AEAEVDQADYSVFNQ 826

  Fly   829 DK-------STLEFGQPGLQTLLASRQQSA------KRRF-IIPTMYLLEELRQLLIADTRNWFL 879
            :|       |:::.....|.|...|||.:.      :::| .:..:::|...|:      |...:
Zfish   827 EKVEEEGDASSMDDTDQRLLTFSDSRQDTVTGHALWRQQFSTVAWLHMLNLQRE------RKPII 885

  Fly   880 PILKLTLPSLVVVWTLSMPYFWHNCRQPGHITFPMSDHGDGIILMQKDTLDSELLVASEMYAKVG 944
            ..|.|.:..|..:..||:.........|..:..|       |.|::::.       |...|....
Zfish   886 YNLTLFVVFLSAMLILSVATGNIQIHSPERLFSP-------IYLLRRNE-------APHKYTTSL 936

  Fly   945 VTEVDKTVDITTFIYN---YEYKNSLLSDADIMEAVIFS---NV-------QIEVLFNTKWPHTA 996
            :.:.....|::.||:|   .:.|..::...|.|.|...|   ||       ...:.||:...|
Zfish   937 LVQNSTDSDLSGFIHNLQSQDIKVEMMKKLDYMSAAPVSAAINVTGPSKDFTYILAFNSTTVH-- 999

  Fly   997 PDSLAQALNSLAVAFIDGDAG-----------------------IKVELEVLP---------FST 1029
              ||..|:|.|:.|.:.|..|                       :.:|..:|.         |:.
Zfish  1000 --SLPMAVNVLSNALLRGYNGTGHIRTWSKPFDYQIPDKTSYALVYIEAVILGMLAAGMPAYFAM 1062

  Fly  1030 IHTL-----------------------QLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDG 1071
            .||.                       |..:::..|.||.....|..|.|       |.|
Zfish  1063 DHTRDRELKCRSTLRISGLVPSAYWCGQAAIDVPFYYLILTCMTSTLFAF-------HST----- 1115

  Fly  1072 RYNYVELIAGMPTIVLIVAFLIYELLVVLLALFPINIAVIFFHW-----DLLMDSNIHIYSVYVM 1131
                 .|:..            :.:|.|.|.|...:.|::.|.:     .:.:.||...:||..|
Zfish  1116 -----NLLTS------------HNILSVALCLIGFSPAMVLFTYCVSFMFVRVQSNRDFFSVVSM 1163

  Fly  1132 FIIAACVFSLNILITIMPISDMPFVYLKVLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPF 1196
            .:   ||.|.:|:       .:..|.....:|..|                    |..|..|.|.
Zfish  1164 MV---CVVSASIV-------QLALVNESASMARLL--------------------HNALCFFSPL 1198

  Fly  1197 YALLH--NLMRIASISEK------IWLCSDRQIYETSVYADQCNTIPNCCDDDAQEFYHLRYLCC 1253
            |.|:.  |.:.:|:..:.      :|    :.:: .||.|.                    |:.|
Zfish  1199 YPLMGCLNCITVATFVQSPHDDDFLW----KNLF-ISVVAP--------------------YIQC 1238

  Fly  1254 VYLLLVVVWISIFI---FLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSELENTWIHEKS 1315
            :.||:.:.|:.|..   .:|:..:.|...|.|.....:|:....::     |..::|...:.|..
Zfish  1239 ILLLVSLRWLEIRYGGKTMKNDQLCRISSQAKSKAQRNPEENMSED-----EDVQMEKARVKEAM 1298

  Fly  1316 R-----------VSTLERNHIESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKS 1369
            .           ||.|.:.:...:    |..|:....|.|.|:|.|.|.:.:|:.:.|.||.|||
Zfish  1299 TCQCCEEKPVVVVSNLRKQYKGKR----EGFSLNKKRKVATKNISFCVRKGEVLGLLGPNGAGKS 1359

  Fly  1370 VLLKTILGIYTPSSGRII-SSKTVPFKSKDLDSCHMVGYSAQEFQTMQLMTILETWDLILRIRRS 1433
            .::..:.|....::|:|: ......|:..:....| |||..|.......:|:.|..::...|:..
Zfish  1360 TIMHMLSGDTEATAGQILMGDYGTDFQPAENPLEH-VGYCPQVNPLWPRITLQEHLEIYSAIKGL 1423

  Fly  1434 KQISFRAEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQR 1498
            :|........::.....|..:.:......|.|:.::|...::::.:.:::|||:|.|.:|..|::
Zfish  1424 RQRDIPNIIKRVVSALELKDHLYKQSKNLSAGLKRKLCFALSMLGNPQIVLLDEPSTGMDPKSKQ 1488

  Fly  1499 SMLHIIHDL---RRRGHSIIYTCSDTAYSTPAL----RMATLSYPGIAVIGEREEMQQNYYSSYY 1556
            .|...|...   ::||..:     .|.|...|.    |:|.:....:..||..:.::..:...|
Zfish  1489 RMWRAIRAAFKNKQRGALL-----TTHYMEEAEAVCDRVAIMVSGQLRCIGSIQHLKGKFGRGY- 1547

  Fly  1557 MVETRIHLAELGSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIEN 1621
                              |.....:|:..|.....|.||.                      |..
Zfish  1548 ------------------SLEINLREELTGLQQVALLHKE----------------------ILK 1572

  Fly  1622 VFPHAIIKNVSFPRVCFWLSSHMYPMSRIVD------TLHRNKQDF----YSFSVSQPSVNSVFL 1676
            :|||| ::..||..    :..:..||..:..      .|...||:|    |:|  ||.::..||:
Zfish  1573 IFPHA-VRQDSFAT----MMVYKIPMEDVKSLAKSFAQLESAKQNFNFEEYNF--SQSTLEQVFM 1630

  Fly  1677 SIHRQKSNKD 1686
            ...:::.|::
Zfish  1631 EFAKEQENEE 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	123/515 (24%)
		ABC_subfamily_A	519..737	CDD:213230	62/231 (27%)
		P-loop_NTPase	1330..1517	CDD:422963	43/190 (23%)
abca5	XP_005156458.1	ABC2_membrane_3	<165..395	CDD:289468	56/288 (19%)
		CcmA	498..810	CDD:224054	71/311 (23%)
		ABC_subfamily_A	500..723	CDD:213230	58/222 (26%)
		ABC2_membrane_3	889..>1148	CDD:289468	53/305 (17%)
		CcmA	1307..1634	CDD:224054	79/384 (21%)
		ABC_subfamily_A	1309..1540	CDD:213230	53/240 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850