Protein Alignment CG43672 and abca1b

DIOPT Version :9

• Sequence 1: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Sequence 2: XP_005173137.1
• Gene: abca1b / 100136868
• ZFINID: ZDB-GENE-030131-9826
• Length: 2282
• Species: Danio rerio
• Alignment Length: 2069
• Identity: 386/2069 - (18%)
• Similarity: 704/2069 - (34%)
• Gaps: 646/2069 - (31%)

  Fly    13 VWKNFQKQKHNKLVLILSLVLPVMSSLFLLFIRSSSDSNMRDYSIRAEAELLEFSWS-----SLI 72
            || ||. :..|::.|:.:|:|..:::.|.                  .|:|....||     |.:
Zfish   427 VW-NFM-ENSNEMDLMRTLLLNNLTANFF------------------SAQLAGTQWSVEDVISFL 471

  Fly    73 GKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNA--ALRRLMG----DALGKLSMSEDKIVDF 131
            .|..|......:.   ||.       |..|.....|  ::.|.|.    |.|..:| :|:|:|
Zfish   472 SKHSEDTRPQGTA---FTW-------RDVFNETDQAIMSISRFMECVNLDKLEPVS-TEEKLV-- 523

  Fly   132 ENCNDMRIHAASEHYLASVCFRNVDESLNGLPTVLNFAIIMPSELRNYEDTWIGDSWKETTTLMD 196
               |:......:..:.|.:.|.::..:.:.||..:|:.|                       .||
Zfish   524 ---NESMSLLDNRKFWAGIVFLDIPSNSSELPPNVNYKI-----------------------RMD 562

  Fly   197 RDVAEEDEFDEDGYTD------------YMGEGFVPLQYHISMQFLRA-TASK------VEKLP- 241
            .|..|.....:|||.|            |:..||..||..:....:|| |.||      ::::|
Zfish   563 IDNVERTNKIKDGYWDPGPRADPFEDLRYIWGGFSYLQDVVEHSIIRAVTGSKEKTGVYIQQMPY 627

  Fly   242 -----KVVMRRFNENPNVLLSEGIGTSVVLLILLGFMFPVTILTTLIVEERELGQRYMLKILNAS 301
                 .:.:|        ::|.    |:.|.:.|.:|:.|.|:...:|.|:|...:..::|:...
Zfish   628 PCYVDDIFLR--------IMSR----SMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLD 680

  Fly   302 ATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPWP---ILLCFLISYGCSVTSLII 363
            ..:...:||.:.....||::.|:.:|||:.        |..|:.   ::..||.|:.........
Zfish   681 NGILWFSWFISSLIPLLISAGLLVLLLKMG--------NLLPYSDPGVVFLFLGSFAVVTIMQCF 737

  Fly   364 LMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFA----TVLLCNVSFSRGLSKI 424
            |:::|..|:.:|.....||:..|.||.     :|......:.|||    ..||..|:|..|....
Zfish   738 LISTAFARANLAAACGGIIYFTLYLPY-----VLCVAWQDYVGFAAKVIASLLSPVAFGFGCEYF 797

  Fly   425 FYIEDYTLGVTIGKYMFYRVSKSDFGI------------FVPIVCFYVQTIF------------- 464
            ...|:..:|:.........|.:.|:.:            ...::.:|::|:|
Zfish   798 ALFEEQGVGIQWNNLFSSPVEEDDYNLTTCLILMYFDAFLYGVMTWYIETVFPGQYGIPRPWYFP 862

  Fly   465 ---------------------------CTLLAMIFENNAYFWLAIRVKNLLKKY-HATRSAVGRL 501
                                       |     |.|...:..|.:.::||:|.| |..:.|
Zfish   863 FTKSYWFGENSTNNTAIHGKKSNAGAVC-----IEEEPTHLKLGVYIENLVKVYRHGKKLA---- 918

  Fly   502 KRQIPEVSFSKTSAEALIEFRGVWQKYSNSTYVVQDITLNVYAGEVVALLGHNASGKSTIIKMLY 566
                                             |..:||..:.|::.:.||||.:||:|.:.:|.
Zfish   919 ---------------------------------VDGLTLGFHEGQITSFLGHNGAGKTTTMSILT 950

  Fly   567 GRTRPKLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSKTEAKLEA 631
            |...|..|..|:.|.:|.::.....::..:...:..||:.|.|.:|:.|.:||:|||:.|.|.|.
Zfish   951 GLFPPTSGTAYIMGKDIRSELSSIRQSLGVCPQHNVLFSMLTVEEHIWFYARLKGLSEEEVKAEM 1015

  Fly   632 KALLRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQ 696
            :.:|....|....|:..:.|:.|.:|.|....||.||:::||||:|..|:|.......:.|:|..
Zfish  1016 EQILSDTGLPHKRKSRTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKY 1080

  Fly   697 KKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIF------------ 749
            :..|:|..::::...|..:.|||.::|.|||...|:...|...|...|.|.:.
Zfish  1081 RAGRTILLSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCR 1145

  Fly   750 -GNEKCSF-----------------KDVYAFMATFI-------PEIEMDSILADCASFLVKH--- 786
             .:...||                 .|..:..||.|       |.:.:|..:  .:..::||
Zfish  1146 NSSSTVSFVKKDDNASESSSDAGLGSDQESEAATAIGTSWPESPVVPVDVTI--ISRLILKHVPA 1208

  Fly   787 ---------------KYHT----ELINLIENLARLKNDLNVYSFEIHECSIDDIL---------- 822
                           .|.:    ..:.|..:|.....||.:.|:.:.:.::::|.
Zfish  1209 ARMVEDQGHEITYVLPYESAKNGAFVELFHDLDDRLADLGISSYGVSDTTLEEIFLKVAEDSGVD 1273

  Fly   823 ------ASLYTRDKSTLEFG---QPGLQTLL---------------------------------- 844
                  .:|..|.:....||   |..|:.|.
Zfish  1274 TEMLSDGTLPVRRQRRHAFGADHQSCLKPLTEDDSFDCNESEGDPESKETDYLSGSDGKGSYQVK 1338

  Fly   845 ---ASRQQ----------SAKR-------RFIIPTMY-------------------------LLE 864
               ..|||          .|:|       :.::|.::                         :.|
Zfish  1339 GWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALNPWMYE 1403

  Fly   865 E------------------LRQLL--------------IADT------RNWFLPILKLTLPSLVV 891
            |                  ||.|.              |.|.      ..|..|.:..::..::.
Zfish  1404 EQFMFFSEDAPYDVSTHKLLRALFDDPGFGTRCMKGESIPDAPCTMGDEEWSTPEVPESIIEILT 1468

  Fly   892 V--WTLSMPYFWHNCRQPG-HITFPMSDHGDG------IILMQKDTLD-------SELLVASEMY 940
            .  ||::.|.....|...| ....|....|.|      |.:.:.:||.       |:.||  :.|
Zfish  1469 TRNWTMNDPSPACECSCNGKKKMLPECPAGAGGLPPPQIKISETETLQNLTGRNISDYLV--KTY 1531

  Fly   941 AKV------------------------------GVTEVDKTVDITTFIYNYEYKNSLLSDADIME 975
            |::                              ...|:|..:.....|:.....:...:|..:..
Zfish  1532 AQIIGKSLKNKIWVNEFRYGGFSLGARSTQVLPPAEEIDDAISRVREIFQLGKDSGSAADRFLKS 1596

  Fly   976 AVIFSN-----VQIEVLFNTKWPHTAPDSLAQALNSLAVAFI-----DGDAGIKVELEVLPFSTI 1030
            ...|.|     ..:::.||.|..|:....|....|.:..|.:     ..:.||......|..:..
Zfish  1597 LSAFINGLDTKNNVKIWFNNKGWHSIGAFLNVMNNGILRANLPPGKDPSEFGITAYNHPLNLTKE 1661

  Fly  1031 HTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGM-PTIVLIVAFLIY 1094
            ...|:.|.....|::.:.|:.|...|:.:..::.:...|..:..:::.|:|: |.:..:..||
Zfish  1662 QLSQVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPYLYWLANFL-- 1724

  Fly  1095 ELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISDMPFVYLK 1159
                                ||:   .|..:.:..|:.|.........:..|.:|:    ...|.
Zfish  1725 --------------------WDM---CNYVVPATLVILIFVCFQQKAYVSATNLPV----LALLL 1762

  Fly  1160 VLLAYSLGILVYIAVKELRP----FTNPNTAHFLLLDFHPFYAL-------------LHNLMRIA 1207
            :|..:|:..|:|       |    |..|:||:.:|...:....:             .|.:..|.
Zfish  1763 LLYGWSITPLMY-------PASFLFKIPSTAYVVLTSVNILIGINGSISTFVMELFGNHEIGGIN 1820

  Fly  1208 SISEKIWL-----CSDRQIYETSVYADQCNTIPNCCDDDAQE-FYHLRYLCCVYLLLV------- 1259
            .|.:.:.|     |..|.:.:         .:.|....||.| |...|:...:...:|
Zfish  1821 DILKNVLLIFPHFCLGRGLID---------MVKNQAMADALERFGENRFRSPLEWDMVGKNLFAM 1876

  Fly  1260 ----VVWISIFIFLKSHMVKRRPRQPKYFWDSDPDSKYDQNILHIMEPSEL--ENTWIHEKSRVS 1318
                ||:..|.:.:          |.::|:                ||..|  :.:.|.|:....
Zfish  1877 AVEGVVFFIITVLI----------QYRFFF----------------EPKSLCPKLSPIGEEDEDV 1915

  Fly  1319 TLERNHIESKA-----LHVEHLSVFF--GLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLLKTIL 1376
            ..||..|.|.|     |.:..|:..:  ..|.|:..:...:...:...:.|.||.||:...|.:.
Zfish  1916 ARERQRIMSGAGQGDILELRQLTKVYKRKQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLT 1980

  Fly  1377 GIYTPSSGR-IISSKTVPFKSKDLDSCHM-VGYSAQEFQTMQLMTILETWDLILRIRRSKQISFR 1439
            |....:.|. .|:.|::   .:::|..|. :||..|......|:|..|..:....:|...:....
Zfish  1981 GDSVVTKGEAFIAGKSI---LREIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPENEVC 2042

  Fly  1440 AEATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDIVSQRSMLHII 1504
            |.|....:..||.||...:....|.|.:::||..|:|:....::.||:|.|.:|..::|::.:.|
Zfish  2043 AVAEWGIRKLGLVKYVDKNAGSYSGGNMRKLSTAISLIGAPPVVFLDEPTTGMDPKARRALWNCI 2107

  Fly  1505 HDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYMVETRIHLAEL 1567
            |.:.:.|.|::.| |.:.....||  |||.:.......:|..:.::..:...|.::     |...
Zfish  2108 HSVIKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTII-----LRVA 2166

  Fly  1568 GSPIDFDSQSTEAKEDRAGTTGTLLRHKHQEFSAAFTDSADRWKYLKLCGVIENVFPHAIIKNVS 1632
            |...|........:.:..|:|   |:.||:..
Zfish  2167 GPDPDLQPVMKFIESELPGST---LKEKHRNM--------------------------------- 2195

  Fly  1633 FPRVCFWLSSHMYPMSRIVDTLHRNKQ--DFYSFSVSQPSVNSVFLSIHRQKSN 1684
               :.:.|.|.:..::.|...|.:||:  ....:||||.:::.||::..:.:|:
Zfish  2196 ---LQYQLPSSLTSLAHIFSILAKNKEFLRIEDYSVSQTTLDQVFVNFAKDQSD 2246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	119/525 (23%)
		ABC_subfamily_A	519..737	CDD:213230	63/217 (29%)
		P-loop_NTPase	1330..1517	CDD:422963	45/190 (24%)
abca1b	XP_005173137.1	rim_protein	1..2242	CDD:130324	385/2063 (19%)
		ABC_subfamily_A	902..1121	CDD:213230	69/255 (27%)
		ABC_subfamily_A	1932..2152	CDD:213230	53/223 (24%)
		DUF4162	2146..2238	CDD:290451	21/135 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010