DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tplus3a and rtf1

DIOPT Version :9

Sequence 1:	NP_724373.1	Gene:	tplus3a / 318904	FlyBaseID:	FBgn0051702	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001077046.1	Gene:	rtf1 / 100000471	ZFINID:	ZDB-GENE-030131-6778	Length:	681	Species:	Danio rerio

Alignment Length:	450	Identity:	119/450 - (26%)
Similarity:	204/450 - (45%)	Gaps:	69/450 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDERLRTRRKIANKLESGGKTAHAFERLLAIRTIKLSKGKCSEDSAEQTK------SSDDCKAQT 59
            |......|.|...||:   |.:.|.|.|.|.|  :..|.:.:|..|::..      .|||.:.:.
Zfish   225 MSHNKERRIKRDEKLD---KKSQAMEELKAER--EKRKNRTAELLAKRQPLKTSEVYSDDEEEEE 284

  Fly    60 RKDVNIEVKETYSGDSSPNSESENTAQNDPQMNVESEERVSNLEQLSRAVLKRNDIKNLLGKPIF 124
            ..|....||...|..||...|.|...:..|:     .:.||..::|:|..|.|:.::.....|.|
Zfish   285 DDDDKSSVKSDRSSRSSSFDEEEEKEEAPPK-----SQPVSLPDELNRIRLSRHKLERWCHMPFF 344

  Fly   125 AEAVIGSFVRINVGK-----VYSIYETIALHQDSKDYRVDGKRTNLTLVLRCGSEKRYSRIDVVS 184
            |:.|.|.||||.:|.     ||.:.|.|.:.:.:|.|::...|||..|.||.|::.|..|::.||
Zfish   345 AKTVTGCFVRIGIGNSSNKPVYRVAEIIDVVETAKIYQLGSTRTNKGLQLRHGNDTRVFRLEFVS 409

  Fly   185 NQPITQKEFLLWLETNLRNRCTLPTLNDIAKKQVQVKNACKYSYTETDVEKLIQDK---KEAGIK 246
            ||..|:.||:.|.|..:.....||||::|.||:..:|.|..|.:.:.|:|.::::|   ::|  .
Zfish   410 NQEFTESEFMKWKEAMMIAGMQLPTLDEINKKEQSIKEAVNYKFNDKDIEDIVKEKDRFRKA--P 472

  Fly   247 QNAAYRKISLIIERDMAAGMNDVEKVQVLEKKILEIDEEPRPQIEKSGQHRYQVLSSTRGVHVP- 310
            .|.|.:|..|:.|:.||....|.:|.:.|:.::.|::|    :.|...:.|.:.:|:...::..
Zfish   473 PNYAMKKTQLLKEKAMAEESGDGDKAKTLQDQLNELEE----RAEALDRQRTKNISAISYINQRN 533

  Fly   311 ---TIYRHELGVPSGGKSS-------FVKRTAKPEQ---------H-ELEKYMRRKYKKSAVVSR 355
               .|...|..:.:.|::|       |.:|..||..         | .:..::.:||...:...:
Zfish   534 RSWNIVESEKALVAEGQNSKNQQMDPFTRRQCKPTMVSNARDPSVHAAILAHLNQKYGSGSGAGQ 598

  Fly   356 SRFKKAFEDCVDSSAVVNDIHMESQQKEGDVETETETETEKGTEKDLHLQRLHTFNIELD 415
                       |:|...|....::.||:.||...|...:|       .|.::|.|::::|
Zfish   599 -----------DNSQQANKQLGQASQKDKDVTKPTSDLSE-------DLFKVHDFDVKID 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tplus3a	NP_724373.1	Plus-3	105..198	CDD:281165	37/97 (38%)
rtf1	NP_001077046.1	COG5296	152..589	CDD:227615	104/379 (27%)
rtf1	NP_001077046.1	Plus-3	325..423	CDD:281165	37/97 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5296
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840