Protein Alignment CG33159 and PLAT

DIOPT Version :10

• Sequence 1: NP_788455.1
• Gene: CG33159 / 318901
• FlyBaseID: FBgn0053159
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 88/283 - (31%)
• Similarity: 123/283 - (43%)
• Gaps: 62/283 - (21%)

  Fly     5 RLLWWLCHLALVLPSSSS---------KTRIVGGKETTISEVP-----YLVYLRQNG-YFICGGS 54
            ||.|..|.    :||.|:         :.||.||....|:..|     :..:.|..| .|:|||.
Human   285 RLTWEYCD----VPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGI 345

  Fly    55 LISSRAVLSAAHCVYGSQPE-------GFTVHAGASRLDQEAPVVRNVVMFHTSPSYSATNFDMD 112
            ||||..:||||||.....|.       |.|........:|:..|.:.:|    ...:....:|.|
Human   346 LISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIV----HKEFDDDTYDND 406

  Fly   113 VALLQL--------QEVVVLTPGKVATISPCRNP-----PEGNAYARISGWGVTRENNREPAEQV 164
            :|||||        ||..|     |.|:  |..|     |:... ..:||:|.....:...:|::
Human   407 IALLQLKSDSSRCAQESSV-----VRTV--CLPPADLQLPDWTE-CELSGYGKHEALSPFYSERL 463

  Fly   165 RTTMVRVLPGAECKISYSGYGQLSDSMLCAA-------VRGLRDSCSGDSGGPLVY----RGQVC 218
            :...||:.|.:.|...:.....::|:||||.       ...|.|:|.||||||||.    |..:.
Human   464 KEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLV 528

  Fly   219 GIVSWGFGCARPSFPGVYTNVAS 241
            ||:|||.||.:...|||||.|.:
Human   529 GIISWGLGCGQKDVPGVYTKVTN 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33159	NP_788455.1	Tryp_SPc	25..241	CDD:214473	81/252 (32%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	5/14 (36%)
		Tryp_SPc	313..559	CDD:238113	79/251 (31%)