DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33159 and PRSS53

DIOPT Version :9

Sequence 1:	NP_788455.1	Gene:	CG33159 / 318901	FlyBaseID:	FBgn0053159	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	286	Identity:	73/286 - (25%)
Similarity:	103/286 - (36%)	Gaps:	94/286 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TTISEVPYLVYLRQNGYFICGGSLISSRAVLSAAHC--------------VYGS-QPEGFTVHAG 81
            |...|.|:...:|:.|..||.|||::...||:||||              |.|| |.||.:  .|
Human    43 TVPGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLS--PG 105

  Fly    82 ASRLDQEAPVVRNVVMFHTSPSYSATNFDMDVALLQLQEVVVLTPGKVATISPCRNPPEGNAYAR 146
            |..:        .|.......:|:..:...|:|||||......||  :....|....|.| |...
Human   106 AEEV--------GVAALQLPRAYNHYSQGSDLALLQLAHPTTHTP--LCLPQPAHRFPFG-ASCW 159

  Fly   147 ISGW----------------------GVT---------------RENNREPAEQ-------VRTT 167
            .:||                      .||               |.....||..       :|..
Human   160 ATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNL 224

  Fly   168 MVRVLPGAECKISYSGYGQ--LSD----SMLCAAVR-GLRDSCSGDSGGPLVYRGQVC------- 218
            .:|::....|...|:...|  ||:    .|||...: |::..|.||||||:     :|
Human   225 RLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPV-----LCLEPDGHW 284

  Fly   219 ---GIVSWGFGCARPSFPGVYTNVAS 241
               ||:|:...||:...|.:.||.|:
Human   285 VQAGIISFASSCAQEDAPVLLTNTAA 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33159	NP_788455.1	Tryp_SPc	25..241	CDD:214473	72/284 (25%)
CG33159	NP_788455.1	Tryp_SPc	26..251	CDD:238113	73/286 (26%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	73/286 (26%)
		Tryp_SPc	43..314	CDD:214473	73/286 (26%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010