DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNRNPH3 and glo

DIOPT Version :9

Sequence 1:	NP_001309363.1	Gene:	HNRNPH3 / 3189	HGNCID:	5043	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_650120.1	Gene:	glo / 41431	FlyBaseID:	FBgn0259139	Length:	586	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	136/461 - (29%)
Similarity:	184/461 - (39%)	Gaps:	186/461 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    10 PNDASD--------GT---VRLRGLPFGCSKEEIVQFFQGLEIVPN--GITLTMDYQGRSTGEAF 61
            |.:|.:        ||   |:|||||:..::::|.:||.||:|..:  ||...||.:||:|||||
  Fly   129 PKEAKEAMRKISGHGTAFVVKLRGLPYAVTEQQIEEFFSGLDIKTDREGILFVMDRRGRATGEAF 193

Human    62 VQFASKEIAENALGKHKERIGHRYIEIFRSSRSEIK-------GFYDPPRRLLGQRPGPYD---- 115
            |||.|::..|.|||:::|:||||||||||||.:|:|       |        :|.||||||
  Fly   194 VQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMKRATGAGGG--------VGGRPGPYDIRDR 250

Human   116 ------------RPIGGRGGYYGAGRGSMY------DRMRRG----------------------- 139
                        |...|..|.:|.|..:|.      ..|..|
  Fly   251 GANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGGNNGNFGNNSGPSNFG 315

Human   140 --GDGYDGG-------------------------YGG-------------FDDYGGYNNYG---- 160
              |.|.:||                         :||             |:..||.||:|
  Fly   316 NFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNNFNSPGGVNNFGNNGG 380

Human   161 ---------------------------------------YGNDGFDD---RMRDGRGMGGHGYGG 183
                                                   :||.||.:   ....|...||...||
  Fly   381 SNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFGGNNNVGSNFGGGNNGG 445

Human   184 AGDASSGFH---------GGHF---------------VHMRGLPFRATENDIANFFSPLNPIRVH 224
            .|..::|.:         ||:|               :||||||:.:.|||:..||.|:.|..|.
  Fly   446 GGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFENDVFKFFEPIRPANVR 510

Human   225 IDIGADGRATGEADVEFVTHEDAVAAMSKDKNNMQHRYIELFLN-STPG--GGSGMGGSGMGGYG 286
            |:....|..:|.||..|.|:||:..||.:.:..|..||||||.: .|.|  ||...||:|.||.|
  Fly   511 INYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRGLNGGEHGGGNGGGGMG 575

Human   287 RDGMDN 292
            .:|..|
  Fly   576 NNGGGN 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPH3	NP_001309363.1	RRM2_hnRNPH3	1..93	CDD:410131	47/95 (49%)
HNRNPH3	NP_001309363.1	RRM3_hnRNPH3	195..269	CDD:241179	33/89 (37%)
glo	NP_650120.1	RRM_SF	51..125	CDD:302621
		RRM2_hnRNPH_like	146..224	CDD:240948	42/77 (55%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:240950	32/73 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155220
Domainoid	1	1.000	78	1.000	Domainoid score	I8778
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	1	1.000	-	-		FOG0000855
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.900