DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33127 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_787956.1	Gene:	CG33127 / 318893	FlyBaseID:	FBgn0053127	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	261	Identity:	73/261 - (27%)
Similarity:	115/261 - (44%)	Gaps:	16/261 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QHLTLRDTEQVHAEIQPLIIDGYDVQGVDNVPYLVSLSLTRATYTHLCGASIIGKRWLLTAAHCV 87
            |.::||.:|.....:...|:.|..| .....|:..|::|   .:.|.||.|::..||::|||||:
Human   200 QVVSLRCSECGARPLASRIVGGQSV-APGRWPWQASVAL---GFRHTCGGSVLAPRWVVTAAHCM 260

  Fly    88 DELRTFNGDAVGTPVYAGIINRSNVTAAQVRYVDFASTHRSFNGNAGSDNIALLHVSESFEYNAR 152
            ...|.  .......|:||:::.|.|...|...|:....|..::......::|||.:..:..::..
Human   261 HSFRL--ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDT 323

  Fly   153 VQQIALPDINDDYSNKTAAAY--GWGLTDPDGDEYSKELQYAFAPLLNSTGCKELLPADAPLTAQ 215
            |..:.|| ..:.:..|.:..:  |||.|.|.....|..||....||.::..|.........||.:
Human   324 VGAVCLP-AKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPR 387

  Fly   216 QVCS-----QVKTCYGDGGTPLIYWPITGPAELVGLGSWSYMPCGYANRPTVYTSVPPYIGWIHQ 275
            .:|:     :...|.||.|.||: .|......|||:.||. ..|...|.|.||..|..::.|||.
Human   388 MLCAGYLDGRADACQGDSGGPLV-CPDGDTWRLVGVVSWG-RGCAEPNHPGVYAKVAEFLDWIHD 450

  Fly   276 T 276
            |
Human   451 T 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33127	NP_787956.1	Tryp_SPc	41..276	CDD:238113	68/241 (28%)
CG33127	NP_787956.1	Tryp_SPc	41..273	CDD:214473	65/238 (27%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	4/12 (33%)
		Tryp_SPc	217..448	CDD:214473	65/239 (27%)
		Tryp_SPc	218..451	CDD:238113	68/241 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920