DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33127 and PRSS53

DIOPT Version :9

Sequence 1:	NP_787956.1	Gene:	CG33127 / 318893	FlyBaseID:	FBgn0053127	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	343	Identity:	71/343 - (20%)
Similarity:	118/343 - (34%)	Gaps:	95/343 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PLLALAGAAKLPHIQHLTLRDTEQVHAEIQPLIIDGYDVQGVDNVPYLVSLSLTRATYTHLCGAS 73
            |:|.:|||..|........|...| .....|...:|..|.|  ..|:..|:   |....|:|..|
Human     7 PVLLIAGATVLMEGLQAAQRACGQ-RGPGPPKPQEGNTVPG--EWPWQASV---RRQGAHICSGS 65

  Fly    74 IIGKRWLLTAAHCVD-----ELRTFNGDAVGTPVYAGIINRSNVT-AAQVRYVDFASTHRSFNGN 132
            ::...|:||||||.:     ||.:::       |..|.:.|..:: .|:...|......|::|..
Human    66 LVADTWVLTAAHCFEKAAATELNSWS-------VVLGSLQREGLSPGAEEVGVAALQLPRAYNHY 123

  Fly   133 AGSDNIALLHVSESFEYNARVQQIALPDINDDYS-NKTAAAYGWGLTDPDGDEYSKELQYAFAPL 196
            :...::|||.::....:.    .:.||.....:. ..:..|.||.....||..:.: |:...|..
Human   124 SQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPR-LKLGEALC 183

  Fly   197 LNST-----GC----KELLP-----ADAP---------------LTAQQVCSQVKT--------- 223
            |.|.     .|    ..|||     |.||               |.::..|:.:..
Human   184 LPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSN 248

  Fly   224 ------------------CYGDGGTPLI------YWPITGPAELVGLGSWSYMPCGYANRPTVYT 264
                              |.||.|.|::      :|...|   ::...|    .|...:.|.:.|
Human   249 PARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAG---IISFAS----SCAQEDAPVLLT 306

  Fly   265 SVPPYIGWIHQTI-GAYY 281
            :...:..|:...: ||.:
Human   307 NTAAHSSWLQARVQGAAF 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33127	NP_787956.1	Tryp_SPc	41..276	CDD:238113	60/303 (20%)
CG33127	NP_787956.1	Tryp_SPc	41..273	CDD:214473	59/300 (20%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	59/297 (20%)
		Tryp_SPc	43..314	CDD:214473	58/294 (20%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010