DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33127 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_787956.1	Gene:	CG33127 / 318893	FlyBaseID:	FBgn0053127	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	268	Identity:	63/268 - (23%)
Similarity:	105/268 - (39%)	Gaps:	68/268 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PYLVSLSLTRATYTHLCGASIIGKRWLLTAAHCVDELRTFNGDAVGT----PVYAGIINRSNVTA 114
            |:..||.:..   .|:||.::|..||::|||||      |..|::.:    .|:.|.:.:::...
Human   580 PWQASLQVRG---RHICGGALIADRWVITAAHC------FQEDSMASTVLWTVFLGKVWQNSRWP 635

  Fly   115 AQVRY-VDFASTHRSFNGNAGSDNIALLHVSESFEYNARVQQIALPDINDDY------------- 165
            .:|.: |.....|.....::...::|||.:......:|.|:.:.||..:..:
Human   636 GEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA 700

  Fly   166 -------SNKTAAAYGWGLTDPDGDEYSKELQYAFAPLLNSTGCKELLPADAPLTAQQVCSQV-- 221
                   ::..|..|||         .::..:....|:.|:     |...|..|..|.:||:|
Human   701 LREGALRADAVALFYGW---------RNQGSETCCCPISNA-----LQKVDVQLIPQDLCSEVYR 751

  Fly   222 -----------------KTCYGDGGTPLIYWPITGPAELVGLGSWSYMPCGYANRPTVYTSVPPY 269
                             ..|.||.|.||:...::|...|.||.||. :.||..|...|||.:...
Human   752 YQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWG-LGCGRPNYFGVYTRITGV 815

  Fly   270 IGWIHQTI 277
            |.||.|.:
Human   816 ISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33127	NP_787956.1	Tryp_SPc	41..276	CDD:238113	62/265 (23%)
CG33127	NP_787956.1	Tryp_SPc	41..273	CDD:214473	60/262 (23%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	62/265 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010