Protein Alignment CG33124 and SLC5A2

DIOPT Version :10

• Sequence 1: NP_001097056.3
• Gene: CG33124 / 318891
• FlyBaseID: FBgn0053124
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 137/626 - (21%)
• Similarity: 249/626 - (39%)
• Gaps: 128/626 - (20%)

  Fly    10 DYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKVFPVA 74
            |..|.....:|.|.:||:                   .:...|.|:  :..|.:....:..:||.
Human    25 DILVIAAYFLLVIGVGLW-------------------SMCRTNRGT--VGGYFLAGRSMVWWPVG 68

  Fly    75 MSLIASFIS-----GVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEY 134
            .||.||.|.     |:|..|..|.:...|.:::.:.:.:::     .:::.||:....|.:..:|
Human    69 ASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLL-----GWLFAPVYLTAGVITMPQY 128

  Fly   135 LGMRFHPLIRNIVSIMFVIEVLLY--TPFVV--FVPALALNQASGLNIHMIEVLIIVVCVIYTLL 195
            |..||..  |.|...:.|:.:.||  |...|  |..|:.:.||.|.||:...:.::.:.:|||:.
Human   129 LRKRFGG--RRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVT 191

  Fly   196 GGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLI-------FGNIN---- 249
            |||.|:::||..|..::.....::...|...:......|:..:.....:       .|||:
Human   192 GGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCY 256

  Fly   250 ---PSPY--VRNTV-----WSVVIGG-----AFYWTSITAVHQTMVHRYM---SLPNLKMARTSI 296
               |..|  :|:.|     |..::.|     .:||.|    .|.:|.|.:   ||.::|......
Human   257 RPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCS----DQVIVQRCLAGKSLTHIKAGCILC 317

  Fly   297 AFFVLGSIIFYSVLSFLGLLIFNMYKD---------CDPLSAGQIMNNDQLVPLFVVQSVGHIYG 352
            .:..| :.:|..|:.  |::...:|.|         |..:...::..::...|..||:.:.:  |
Human   318 GYLKL-TPMFLMVMP--GMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPN--G 377

  Fly   353 IPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQP--GETASAIIVKATIVIMGALVFG 415
            :.||.:|.:..|.:|||:...||:|.:...||..   :::|  |:....::.:..:|.:..:...
Human   378 LRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYT---RLRPRAGDRELLLVGRLWVVFIVVVSVA 439

  Fly   416 EVLLLEKVSG--ILSICMSLVAIATSSTFGIFTLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQ 478
            .:.:::...|  :.....::.:........:|.||:.||..|..| |..|:.|.||.|......:
Human   440 WLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQG-AFWGLIGGLLMGLARLIPE 503

  Fly   479 IAAASGQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINPIGALTVVVVGSLVSL 543
            .:..||..      |..::||..:.....::.    ...||..|       |.||:.     |||
Human   504 FSFGSGSC------VQPSACPAFLCGVHYLYF----AIVLFFCS-------GLLTLT-----VSL 546

  Fly   544 VTKPTDIKSLDSDLISPVIHRFLPKECFKQRNLDKSEATDI 584
            .|.|...|.|         ||.:    |..|: .|.|..|:
Human   547 CTAPIPRKHL---------HRLV----FSLRH-SKEEREDL 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	121/573 (21%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	137/626 (22%)