DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33124 and slc5a6a

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001020700.2	Gene:	slc5a6a / 563356	ZFINID:	ZDB-GENE-041001-177	Length:	625	Species:	Danio rerio

Alignment Length:	607	Identity:	188/607 - (30%)
Similarity:	317/607 - (52%)	Gaps:	57/607 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTYR--FGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMG 64
            ||.:  |.||||.:|:.:.:.|..||||:.:....::..:                    |:|:.
Zfish     3 DTVQMHFSTVDYVIFVVLLVASAGIGLYYAFSGGRQRTTQ--------------------EFLLA 47

  Fly    65 SGHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVR 129
            ...::..||::||:|:|.|.|||||.|||||.|||||..:..:..:..|..::|::|||..|::.
Zfish    48 DRSMRCLPVSLSLLATFQSAVAILGAPSEIYTYGTQYWFLGCSYFLGLLIPAHIFIPVFYRLRLS 112

  Fly   130 SSYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTL 194
            |:||||.:||...:|...::.|:.::::|...|::.||||||..:|.::....:.:.:||.:||.
Zfish   113 SAYEYLELRFSKSVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFDLWGAVLAMGLVCTLYTA 177

  Fly   195 LGGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVW 259
            |||||||:.||::|.::|||..:.|.::.|.....:.:.:....:|.|:...::||.|..|:|.|
Zfish   178 LGGLKAVIWTDVFQTIVMFAGQLAVIVVGTHQAGGIAEVWRKAQNGSRIAGLDLNPDPLERHTFW 242

  Fly   260 SVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTS-IAFFVLGSIIFYSVLSFLGLLIFNMYKD 323
            ::.:||.|...::..|:|..|.||:|....|.|..| .|.|....::. ::...:||:::..|.:
Zfish   243 TLGVGGVFLMLALYGVNQAQVQRYLSSRTEKEAIMSCYAVFPCQQVVL-TLGCLMGLVMYARYGE 306

  Fly   324 CDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGC 388
            ..||..|.:..|||:|...|:..:..:.|:||||:|.:|...||::|...||.:.|.::|:::
Zfish   307 ESPLDQGYVTTNDQMVLYLVMDVLRDLPGLPGLFVACLFSGALSTISSAFNSLATVTMEDLIK-- 369

  Fly   389 FKMQPGETASAIIVKATIVI-MGALVFGEVLL-----LEKVSGILSICMSLVAIATSSTFGIFTL 447
             ...|..|.:    :||::. |.||.:|.|.|     ...:..:|...:|:..:......|:|.|
Zfish   370 -PHVPAMTEA----RATLLSKMLALAYGLVCLAMAYIASLMGSVLQAALSIFGMVGGPLLGLFCL 429

  Fly   448 AVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPV---SVASCPGNVTARENVW 509
            .:..||||:.|..||..:|.::..||..||.::    ::....|||   ::....||:|......
Zfish   430 GMFFPWANSTGALVGLASGLVMAFWIGIGSFVS----RMSLSALPVINATIIPDVGNMTTAVMTT 490

  Fly   510 VDEEQVFP-----LFRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIHR---FL 566
            :...:..|     |:.||:.|.:...:.||||||.:||.:|.|...|.|:...:.||:..   ||
Zfish   491 LTTTKPRPSGVQALYSLSYMWYSAHNSATVVVVGLVVSFLTGPWKEKDLNPGTVYPVLGNLLFFL 555

  Fly   567 P-----KECFKQRNLDKSEATD 583
            |     |.|......|||:..|
Zfish   556 PQRYREKLCCVTPLEDKSKDLD 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	161/538 (30%)
slc5a6a	NP_001020700.2	SLC5-6-like_sbd	9..532	CDD:294310	171/554 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820