DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and slc5a5

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	585	Identity:	179/585 - (30%)
Similarity:	282/585 - (48%)	Gaps:	55/585 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYR---FGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYL 62
            ||:.|   |..|||.||..:..:|:.|||:            .|...||       |..|::.:.
Zfish     3 MDSDRPPGFCLVDYAVFAAMLGVSVGIGLF------------QSLRKTP-------GRSKVDSFF 48

  Fly    63 MGSGHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQ 127
            .|.......||.:||.|||:|.|.:||.|||.|.||.::..:.|...:..|..:.:::|||..|:
Zfish    49 TGGRGFSAVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYRLK 113

  Fly   128 VRSSYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIY 192
            :.||.:||||||...::.:.|:.|::..||||..|:|.||:.||||:|||:........::|..|
Zfish   114 ITSSSQYLGMRFGRGMQLLGSLQFIVATLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICTFY 178

  Fly   193 TLLGGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNT 257
            |.:||:|||:.||::|:|:|.:..:.|.|..|..........|...:|.|:.|.:....|..|.:
Zfish   179 TTVGGMKAVIWTDVFQIVVMLSGFIAVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYS 243

  Fly   258 VWSVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSFLGLLIFNMYK 322
            .||..:||...|.|:...:|..|.||:|....|.|:.::....:|..:..|..:..|:::|.:|.
Zfish   244 FWSFTVGGTMVWLSMYGANQAQVQRYISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYS 308

  Fly   323 DCDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRG 387
            :||||..|:|...||.:|..|:....:..|.||||:|..:...||::|..:|:.:.|.::|:
Zfish   309 NCDPLKIGRISAPDQYMPYLVLDIFRNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDV--- 370

  Fly   388 CFKMQP-----GETASAIIVKATIVIMGALVFGEVLLLEKVS----GILSICMSLVAIATSSTFG 443
               |:|     .:....::.:|..:..|   .|.:.:....|    |:|....:::.:......|
Zfish   371 ---MKPWLITISQRKQLMLSRALSLFYG---LGCITMAALSSLLDWGVLQGSFTVMGVVNGPLLG 429

  Fly   444 IFTLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASC-PGNVTAREN 507
            .|.|.:.||..|..|...|...||.|:.|:..||.|...|.|: ...||.|...| ..|.|....
Zfish   430 AFALGMFVPATNKPGVFSGVAVGFCLSLWLAVGSTIYPPSPQI-MGVLPTSAGQCLTTNATLNTT 493

  Fly   508 VWVDEEQVFPL-------FRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIHRF 565
            ..|....| ||       :.:|:.:...:....||:||.:||.:|.||     ..|.|||.:.|:
Zfish   494 ASVLASSV-PLDYSFQNIYSISYLYFGALSTSAVVLVGVVVSYITGPT-----KKDSISPGLLRW 552

Fly 566 565
Zfish 553 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	161/540 (30%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	174/569 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950