Protein Alignment CG33124 and slc5a1

DIOPT Version :10

• Sequence 1: NP_001097056.3
• Gene: CG33124 / 318891
• FlyBaseID: FBgn0053124
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_956975.1
• Gene: slc5a1 / 393654
• ZFINID: ZDB-GENE-040426-1524
• Length: 658
• Species: Danio rerio
• Alignment Length: 634
• Identity: 139/634 - (21%)
• Similarity: 256/634 - (40%)
• Gaps: 144/634 - (22%)

  Fly    27 YFGW------IKKTKKEMESSPADTPEI--------SIPNFGSKKMNEYLMG----SGHLKV-FP 72
            |||:      :|:......::|||...|        ::..:...:.|...:|    :|...| :|
Zfish     5 YFGFSLLRNDVKRNTTIYVNNPADISVIVIYFLVVLAVGVWAMVRTNRATVGGFFLAGRSMVWWP 69

  Fly    73 VAMSLIASFIS-----GVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSY 132
            :..||.||.|.     |:|..|..:.|...|.:::.:|:.|::     .::::|::....|.:..
Zfish    70 IGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVIIL-----GWLFVPIYIKAGVVTMP 129

  Fly   133 EYLGMRFHPLIRNIVSIMFVIEVLLYTPFV-----VFVPALALNQASGLNIHMIEVLIIVVCVIY 192
            |||..||..  :.|...:.|:.:.||. |.     :|..|:.:|||.||||::..|:::::..:|
Zfish   130 EYLKKRFGG--QRIRIYLSVLSLCLYV-FTKISADMFAGAIFINQALGLNIYLAVVILLLITALY 191

  Fly   193 TLLGGLKAVVHTDIWQVVIM---------FA-------------------SVVVVAILATCYITD 229
            |:.|||.||::||..|.:||         ||                   ||:...|..:||...
Zfish   192 TVTGGLAAVIYTDTLQTIIMVVGSFILMGFAFNKVGGYENFRDSYMTAIPSVIGTNISESCYTPR 256

  Fly   230 LDDF--FESLVDGG----RLIFGNINPSPYVRNTVWSVVIGGAFYWTSITAVHQTMVHRYMSLPN 288
            .|.|  |...::|.    .|:||              :.|...:||    ...|.:|.|.:|..|
Zfish   257 ADSFHIFRDPINGDLPWPGLLFG--------------LTIQAGWYW----CTDQVIVQRCLSAKN 303

  Fly   289 LKMARTSIAFFVLGSIIFYSVLSFLGLLIFNMYKD---------CDPLSAGQIMNNDQLVPLFVV 344
            |...:..........::...::.|.|::...:|.|         |..:...::...:...|..||
Zfish   304 LSHVKAGCILCGYLKLLPMFLMVFPGMISRVLYPDEIACVDPDECKAVCGAEVGCTNIAYPKLVV 368

  Fly   345 QSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQPGETASAIIVKA---TI 406
            ..:.:  |:.||.::.:..:.:|||:...||.|.:...||..   |::|......:::..   .:
Zfish   369 DLMPN--GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYT---KIRPKAKEKELMIAGRLFML 428

  Fly   407 VIMGALVFGEVLLLEKVSG-ILSICMSLVAIATSSTFGIFTLAVLVPWANTVGTAVGGIAGFLLT 470
            :::|..:....::....|| :.....|:.:........:|.||:.....|..|...|...| ||.
Zfish   429 LLIGISIAWIPIVQTAQSGQLFDYIQSITSYLAPPIAAVFALAIFCKRVNEPGAFYGLCVG-LLV 492

  Fly   471 GWITFGSQIAAASGQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINPIGALTVV 535
            |.....::.|..:|..      |:.::||..:.....::      |.|.         :..|:.:
Zfish   493 GLARMITEFAYGTGSC------VNPSNCPTIICGVHYLY------FALI---------LFGLSCI 536

  Fly   536 VVGSLVSLVTKPTDIKSLDSDLISPVIHRFLPKECFKQRNLDKSEATDI 584
            ::.| :||:|||.:.|.|         :|.    |:..|| :..|..|:
Zfish   537 LILS-ISLMTKPIEDKHL---------YRL----CWSLRN-NTEERIDL 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	124/581 (21%)
slc5a1	NP_956975.1	SLC5sbd_SGLT1	27..658	CDD:271379	134/612 (22%)