DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and slc5a12

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	598	Identity:	191/598 - (31%)
Similarity:	311/598 - (52%)	Gaps:	71/598 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTY-RFGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMG 64
            |:|. ||...||.||..:.::|..||::|     ..||...:|:               .|:|:|
Zfish     1 METVGRFQAGDYVVFACLFVVSSGIGVFF-----AIKERNKAPS---------------KEFLVG 45

  Fly    65 SGHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYI-------YLPV 122
            ...:...|||:||.|||:|.|.::|.|:::|.:|..|       ||.|:|.:::       :|||
Zfish    46 GRQMSCGPVALSLTASFMSAVTVIGAPADVYRFGASY-------VIFGVAYTFVVFFTAELFLPV 103

  Fly   123 FSALQVRSSYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIV 187
            |....:.|:||||.:||..|:|...:::::|:.:|||..||:.|||||||.:|.::........:
Zfish   104 FYRSGITSTYEYLELRFCKLVRVAATLIYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGI 168

  Fly   188 VCVIYTLLGGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSP 252
            ||..|..||||||||.||.:|:|:|....:.|.|..:.....:::.:.:...||||...:.:.||
Zfish   169 VCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSP 233

  Fly   253 YVRNTVWSVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLG--SIIFYSVLSFLGL 315
            ..|:|.|::.:||.|.|..|..|:|:.:.|.:|......||.::...:||  .|:|.:|:|  ||
Zfish   234 LRRHTFWTLSVGGTFTWLGIYGVNQSTIQRCISCKTEGHARWALYLNLLGLWIILFCAVVS--GL 296

  Fly   316 LIFNMYKDCDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVI 380
            ::::.|..|||.|:|.|...|||:|.||::.:|...|:||||:|..|...||:::..:|:.:.|:
Zfish   297 IMYSYYSHCDPWSSGLISAPDQLMPYFVMEILGAFPGLPGLFVACAFSGTLSTVAASINALATVM 361

  Fly   381 LQDIVRGCFKMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIF 445
            .:|.|..||. .....|::.|.||..|..|.......:....:.||:...:|:..:......|:|
Zfish   362 YEDFVSQCFP-DLSNRAASWISKALCVAFGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLF 425

  Fly   446 TLAVLVPWANTVGTAVGG-IAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASCPGNVTA----- 504
            :|.:|.|:.|..| |||| |.|..|:.|:..|:.|..|... :.|.|.::.|.|  |:||
Zfish   426 SLGILFPFTNLKG-AVGGLIVGISLSFWVGVGAFIYPAPSN-NTHALELNTAGC--NITAAAFEP 486

  Fly   505 ---------RENVWVDEEQVFPLFRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISP 560
                     .:..|:.:.    .:.:|:.:.:.:|.:..|..|.|::|:|.|.|.|     |:.|
Zfish   487 TSATVTQLTSDRNWLADS----WYSMSYLYYSAVGFIGTVAAGLLITLLTGPMDPK-----LLKP 542

  Fly   561 VIHRFLPKE--CF 571
            .:.|.: ||  ||
Zfish   543 GMTRSV-KEVMCF 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	172/547 (31%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	178/566 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950