DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and CG32669

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	191/589 - (32%)
Similarity:	300/589 - (50%)	Gaps:	57/589 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKK--MNEYLMGSGHLK 69
            |..|||:...|.|:|:|||:|:.::                      |.|:  ..|||:....:.
  Fly     5 GAWDYTILAVVLIISVAIGIYYRFV----------------------GGKQSTTTEYLLADRSMN 47

  Fly    70 VFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEY 134
            |.|||.||:|||:|.|.|||...|.|.|||.:.:|.|:.|:.....:|:.:|||..|:..|.|||
  Fly    48 VAPVAFSLMASFMSAVTILGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEY 112

  Fly   135 LGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLLGGLK 199
            |.:||....|...|:.|.::::||...||:.|||||...:||:.....|::.|||..|..|||:|
  Fly   113 LELRFGYATRLAASLSFSLQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMK 177

  Fly   200 AVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWSVVIG 264
            ||:.|||:|.::|||:|..|.|.|......|:..:....:.||:...|.:..|..|:|.::.::|
  Fly   178 AVLITDIYQSLLMFAAVFSVIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILG 242

  Fly   265 GAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLS-FLGLLIFNMYKDCDPLS 328
            |...:.:|..|:||.|.|.|::.:|..||.:: ::.|..:...|:.: |.||.|:..|:|||||.
  Fly   243 GCATYLAIYGVNQTQVQRLMAVKSLSAARAAL-WWCLPILCLLSLSTCFSGLCIYWYYRDCDPLL 306

  Fly   329 AGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQD----IVRGCF 389
            .|::.:.||::|||||.::|...|:.|||::|||.|.||::|..::|.:.|.|:|    :|..|.
  Fly   307 EGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCA 371

  Fly   390 KMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIFTLAVLVPWA 454
            |....:..:....|...:..|||..|...:...:.|:|...:|:..|......|:|||.:.|..|
  Fly   372 KRTLTDRQTLWYSKLLSLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKA 436

  Fly   455 NTVGTAVGG-IAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASCPGNVTARENVWV-------D 511
            |..| |:|| :.......||.||........      |.:|.|.||.:.:...::::       :
  Fly   437 NEKG-AIGGLLISLAFCFWIGFGQPKPPLVS------LDMSTAGCPVDRSFARDIFLKTVIAVAE 494

  Fly   512 EEQVFPLFRLSFHWINPIGALTVVVVGSLVS------------LVTKPTDIKSLDSDLISPVIHR 564
            ||..|.|:|:|:.|...:|.|.....|.|:|            .:.:..|...:..||..|.|.:
  Fly   495 EEHYFYLYRISYMWYAALGFLITFFGGWLLSWLFALLKWDNNRRIYQDADCTLIKHDLFVPPIAK 559

  Fly   565 FLPK 568
            .|.:
  Fly   560 RLQR 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	180/538 (33%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	184/549 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448264
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900