DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and Slc5a4

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001099853.1	Gene:	Slc5a4 / 294341	RGDID:	1306923	Length:	671	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	133/641 - (20%)
Similarity:	256/641 - (39%)	Gaps:	161/641 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DYTVFLGVTILSIAIGLYFGW-IKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKVFPV 73
            |.:|.:...::.:|:|:   | :.||.:                   ..:..:.:....:..:|:
  Rat    39 DISVIVIYFVVVMAVGV---WAMVKTNR-------------------STVGGFFLAGRSMTWWPM 81

  Fly    74 AMSLIASFI-SG--VAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEYL 135
            ..||.||.| ||  |.:.|..:......|.:.....|::   |.:.:.::|::....|.:..|||
  Rat    82 GASLFASNIGSGHFVGLAGTGAATGIAVTAFESHSFALL---LVLGWFFVPIYIKAGVMTMPEYL 143

  Fly   136 GMRFH----PLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLLG 196
            ..||.    .:..:::|:.  |.|:|.....:|..|:.:..|.||::::...:::.:..::|:.|
  Rat   144 RKRFGGKRLQIYLSVLSLF--ICVILTISADIFSGAIFIKLALGLDLYLAIFILLAITAVFTITG 206

  Fly   197 GLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFE-------SLVDGGRLIFGNINPSPYV 254
            ||.:|::||..|.:||.....::.|.|...:...:.|.|       |:|:|..|   .|:|..|.
  Rat   207 GLASVIYTDTLQAIIMLVGSFILMIYAFVEVGGYESFTEKYMNAIPSVVEGDNL---TISPKCYT 268

  Fly   255 -------------------RNTVWSVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFV 300
                               ..|.:.:.|...:||    .::|.:|.|.:...|  |:....|..|
  Rat   269 PQPDSFHIFRDAVTGDIPWPGTAFGMPITALWYW----CINQVIVQRCLCGKN--MSHVKAACIV 327

  Fly   301 LGSI----IFYSVLSFLGLLIFNMYKD---------CDPLSAGQIMNNDQLVPLFVVQSVGHIYG 352
            .|.:    ||:.|:.  |::...:|.|         |.......:...:...|:.|::.:.  .|
  Rat   328 CGYLKLLPIFFMVMP--GMISRILYTDMVACVVPSECVKQCGVDVGCTNYAYPMLVLKLMP--MG 388

  Fly   353 IPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQPGETASAIIVKAT---IVIMGALVF 414
            :.||.::.:..:.:|||:...||.|.:...|:.            :.|..||:   ::|.|.| |
  Rat   389 LRGLMLSVMLASLMSSLTSIFNSASTLFTMDLY------------TKIRKKASERELLIAGRL-F 440

  Fly   415 GEVLLLEKVSGILSICMSLVAI-----------ATSSTFG-----IFTLAVLVPWANTVGTAVGG 463
            ..||::..:     :.:.:|.:           |.||..|     :|.:|:.....|..|...|.
  Rat   441 VSVLIVTSI-----LWVPIVEVSQGGQLIHYTEAISSYLGPPIAAVFLVAIFCKRVNEQGAFWGL 500

  Fly   464 IAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINP 528
            :.|.:| |.|...::.:..:|..      ::.:|||..:.....::    ....||.:|.
  Rat   501 MVGLVL-GLIRMIAEFSYGTGSC------LAPSSCPKVICGVHYLY----YAIILFFVSI----- 549

  Fly   529 IGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIHRFLPKECFKQRNLDKSEATDI 584
                 :|::|  ||.:|||.           |.:|  |.:.|:..|| .:.|..|:
  Rat   550 -----LVILG--VSYLTKPI-----------PDVH--LYRLCWSLRN-SEEERIDL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	118/588 (20%)
Slc5a4	NP_001099853.1	SLC5-6-like_sbd	38..671	CDD:294310	133/641 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750