DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and Slc5a1

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_037165.1	Gene:	Slc5a1 / 25552	RGDID:	3713	Length:	665	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	130/624 - (20%)
Similarity:	247/624 - (39%)	Gaps:	127/624 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKVFPVA 74
            |.:|.:...::.:|:||:         .|.|:...|            :..:.:....:..:|:.
  Rat    28 DISVIVIYFVVVMAVGLW---------AMFSTNRGT------------VGGFFLAGRSMVWWPIG 71

  Fly    75 MSLIASFIS-----GVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEY 134
            .||.||.|.     |:|..|..:.|...|.:::.:|..:|:     .::::|::....|.:..||
  Rat    72 ASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVFVVVL-----GWLFVPIYIKAGVVTMPEY 131

  Fly   135 LGMRFHPLIRNIVSIMFVIEVLLYTPFV-----VFVPALALNQASGLNIHMIEVLIIVVCVIYTL 194
            |..||..  :.|...:.|:.:|||. |.     :|..|:.:|.|.||:|::...:::.:..:||:
  Rat   132 LRKRFGG--KRIQIYLSVLSLLLYI-FTKISADIFSGAIFINLALGLDIYLAIFILLAITALYTI 193

  Fly   195 LGGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFE-------SLVDGGRLIFG------ 246
            .|||.||::||..|..||.....::...|...:...:.|.:       :||..|.:...
  Rat   194 TGGLAAVIYTDTLQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLVSDGNITVKEECYTP 258

  Fly   247 -----NINPSPYVRNTVWSVVIGG-----AFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVL 301
                 :|...|...:..|..:|.|     .:||    ...|.:|.|.:|..|:...:........
  Rat   259 RADSFHIFRDPITGDMPWPGLIFGLSILALWYW----CTDQVIVQRCLSAKNMSHVKAGCTLCGY 319

  Fly   302 GSIIFYSVLSFLGLLIFNMYKD---------CDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLF 357
            ..::...::...|::...:|.|         |.......:...:...|..||:.:.:  |:.||.
  Rat   320 LKLLPMFLMVMPGMISRILYTDKIACVLPSECKKYCGTPVGCTNIAYPTLVVELMPN--GLRGLM 382

  Fly   358 IAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQPGETASAIIVKA---TIVIMGALVFGEVLL 419
            ::.:..:.:|||:...||.|.:...||..   |::.|.:...:::..   .:|::|..:....::
  Rat   383 LSVMMASLMSSLTSIFNSASTLFTMDIYT---KIRKGASEKELMIAGRLFILVLIGISIAWVPIV 444

  Fly   420 LEKVSG-ILSICMSLVAIATSSTFGIFTLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAAS 483
            ....|| :.....|:.:........:|.||:.....|..|...|.|.|||: |.....::.|..:
  Rat   445 QSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGFLI-GISRMITEFAYGT 508

  Fly   484 GQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINPIGALTVVVVGSLVSLVTKPT 548
            |..      :..::||..:.....::.    ...||.:|        .:||:|    :||:|||.
  Rat   509 GSC------MEPSNCPKIICGVHYLYF----AIILFAIS--------VVTVLV----ISLLTKPI 551

  Fly   549 DIKSLDSDLISPVIHRFLPKECFKQRN-------LDKSE 580
                       |.:|  |.:.|:..||       ||..|
  Rat   552 -----------PDVH--LYRLCWSLRNSTEERIDLDAGE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	113/568 (20%)
Slc5a1	NP_037165.1	SLC5-6-like_sbd	27..665	CDD:382020	130/624 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750