DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33124 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001003915.1	Gene:	Slc5a12 / 241612	MGIID:	2138890	Length:	623	Species:	Mus musculus

Alignment Length:	589	Identity:	185/589 - (31%)
Similarity:	295/589 - (50%)	Gaps:	55/589 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYRFGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGS 65
            |....|...||.||.|:.::|..||::|. ||:.||...                   .|:|:|.
Mouse     1 MRVKNFEAWDYVVFAGLFVISSGIGVFFA-IKERKKTTS-------------------REFLVGG 45

  Fly    66 GHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRS 130
            ..:...|||:||.|||:|.|.:||.|:|:|.:|..:.|.:::.|......|.::||||....:.|
Mouse    46 RQMSFGPVALSLTASFMSAVTVLGTPAEVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITS 110

  Fly   131 SYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLL 195
            :||||.:||:..:|...:|:::::.:|||..||:.|||||||.:|.|:........:||..|..|
Mouse   111 TYEYLQLRFNKPVRYAATIIYIVQTILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSL 175

  Fly   196 GGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWS 260
            |||||||.||.:|:|:|....:.|.|..:.::...::..|...:|.||...:.:..|..|:|.|:
Mouse   176 GGLKAVVWTDAFQMVVMIVGFLTVLIQGSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWT 240

  Fly   261 VVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSFLGLLIFNMYKDCD 325
            :.|||.|.|..:..|:|:.:.|.:|....|.|:.::.|.:||..|..:...|.||::::.:||||
Mouse   241 ITIGGTFTWLGVYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCD 305

  Fly   326 PLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFK 390
            |.::|.|...|||:|.||::....:.|:||||:|..|...||:::..:|:.:.|..:|.|:.||.
Mouse   306 PWTSGVISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFP 370

  Fly   391 MQPGETASAIIVKATIVIMG---------ALVFGEVLLLEKVSGILS----ICMSLVAIATSSTF 442
             ...:..|..|.|...::.|         |.:.|.|:   :..||:|    |..|......|..:
Mouse   371 -HLSDKLSTWISKGLCILFGIMCTSMAVVASLMGSVV---QAPGIVSQERAITGSFQRNLASVCY 431

  Fly   443 GIFTLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQI--AAASGQLHHHRLPVSVASCPG-NVTA 504
            |:..      |...:|...|.:.|..|:.|:..||.|  |..|..|   .||:|...|.. |:|.
Mouse   432 GVSI------WKLIMGALGGLLTGITLSFWVAIGSFIYPAPESKTL---PLPLSTEHCVELNITT 487

  Fly   505 RENVWVDEEQVF--PLFRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIHRFLP 567
            .....:....|.  ..:.||:.:.:.:|.|..:..|.::|.:|.....|.:|..||.||.:.|
Mouse   488 TVAPQISSRPVLADTWYSLSYLYFSAVGCLGCIAAGIIISFLTGKQRGKDIDPLLIRPVCNLF-- 550

  Fly   568 KECF 571
              ||
Mouse   551 --CF 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	170/541 (31%)
Slc5a12	NP_001003915.1	SLC5-6-like_sbd	3..531	CDD:294310	174/560 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836560
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840