DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33124 and SLC5A8

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_666018.3	Gene:	SLC5A8 / 160728	HGNCID:	19119	Length:	610	Species:	Homo sapiens

Alignment Length:	575	Identity:	202/575 - (35%)
Similarity:	316/575 - (54%)	Gaps:	62/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYR-FGTV---DYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEY 61
            |||.| .||.   ||.||.|:.::|.|||:|:                    :....|.:...::
Human     1 MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYY--------------------AFAGGGQQTSKDF 45

  Fly    62 LMGSGHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSAL 126
            |||...:...|||:||.|||:|.|.:||.|||:|.:|..:|:.........:..:.::||||..|
Human    46 LMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKL 110

  Fly   127 QVRSSYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVI 191
            .:.|:||||.:||:..:|...:::|:::.:|||..|::.|||||||.:|.::....|...|||..
Human   111 GITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTF 175

  Fly   192 YTLLGGLKAVVHTDIWQVVIM---FASVVVVAILATCYI-TDLDDFFESLVDGGRLIFGNINPSP 252
            |..|||||||:.||::||.||   ||||::.|::....| |.|:|.:    |||||.|.|.||:|
Human   176 YCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAY----DGGRLNFWNFNPNP 236

  Fly   253 YVRNTVWSVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLG--SIIFYSVLSFLGL 315
            ..|:|.|:::|||.|.||||..|:|:.|.||:|..:...|:.|:...::|  :|:..||  |.||
Human   237 LQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSV--FCGL 299

  Fly   316 LIFNMYKDCDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVI 380
            .:::.|.||||.:|.::...|||:|..|:..:....|:||||:|..:...||::|..:|:.:.|.
Human   300 ALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVT 364

  Fly   381 LQDIVRGCFKMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIF 445
            ::|:::..|: ...|.:.:.|.:...|:.|||..|...|...:..:|...:|:..:......|:|
Human   365 VEDLIKPYFR-SLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLF 428

  Fly   446 TLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLP--VSVASCPGNVTARE-N 507
            .|.:|||:||::|..||.:|||.::.|:..|:||..   .|....||  :.:..|  |.|..| |
Human   429 ALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYP---PLPERTLPLHLDIQGC--NSTYNETN 488

  Fly   508 VWVDEEQVF-------------PL----FRLSFHWINPIGALTVVVVGSLVSLVT 545
            :....|..|             ||    :.||:.:.:.:|.|..::||.||||.|
Human   489 LMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLST 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	188/552 (34%)
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	198/569 (35%)
SLC5A8	NP_666018.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4891
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800