DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33124 and SLC5A12

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens

Alignment Length:	615	Identity:	183/615 - (29%)
Similarity:	301/615 - (48%)	Gaps:	72/615 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYRFGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGS 65
            |:...|...||.||..:..:|..||::|. ||:.||...                   .|:|:|.
Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFFA-IKERKKATS-------------------REFLVGG 45

  Fly    66 GHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRS 130
            ..:...||.:||.|||:|.|.:||.|||:|.:|..:.:..:|.:...|..|.::||||....:.|
Human    46 RQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITS 110

  Fly   131 SYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLL 195
            :||||.:||:..:|...:::::::.:|||..||:.|||||||.:|.::........:||..|..|
Human   111 TYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTL 175

  Fly   196 GGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWS 260
            |||||||.||.:|:|:|....:.|.|..:.:.....:..|...:|.||...:.:..|..|:|.|:
Human   176 GGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWT 240

  Fly   261 VVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSFLGLLIFNMYKDCD 325
            :.:||.|.|..|..|:|:.:.|.:|....|.|:.::.|.:||..|......|.||::::.:||||
Human   241 ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCD 305

  Fly   326 PLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFK 390
            |.::|.|...|||:|.||::....:.|:||||:|..|...||:::..:|:.:.|..:|.|:.||.
Human   306 PWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFP 370

  Fly   391 MQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIFTLAVLVPWAN 455
             ...:..|..|.|...::.|.:.....:....:.|::...:|:..:......|:|:|.::.|:.|
Human   371 -HLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVN 434

  Fly   456 TVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASC-PGNVTAR-----------ENV 508
            ..|...|.:.|..|:.|:..|:.|..|... ....||:|...| ..||||.           .:.
Human   435 WKGALGGLLTGITLSFWVAIGAFIYPAPAS-KTWPLPLSTDQCIKSNVTATGPPVLSSRPGIADT 498

  Fly   509 WVDEEQVFPLFRLSFHWINPIGALTVVVVGSLVSLVT---KPTDIKSLDSDLISPVIHRFLPKEC 570
            |         :.:|:.:.:.:|.|..:|.|.::||:|   :..||:.|   ||.||.:.|    |
Human   499 W---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPL---LIRPVCNLF----C 547

  Fly   571 F-------------------KQRNLDKSEA 581
            |                   :|.||:...|
Human   548 FWSKKYKTLCWCGVQHDSGTEQENLENGSA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	161/535 (30%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	167/554 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850