DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	577	Identity:	162/577 - (28%)
Similarity:	280/577 - (48%)	Gaps:	54/577 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKV 70
            ||..||.||..:.::|..|||:.|                    :...|.:..:::..|...|..
Mouse    12 FGPWDYGVFATMLLVSTGIGLWVG--------------------LARGGQRSADDFFTGGRQLAA 56

  Fly    71 FPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEYL 135
            .||.:||.|||:|.|.:||.|:|...||.::..:.:..::..|..:.::||:|..|.:.|:|:||
Mouse    57 VPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYL 121

  Fly   136 GMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLLGGLKA 200
            .:||...:|...::.:::..:|||..|::.|||.|||.:||:|....:...::|.:||.:||:||
Mouse   122 ELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKA 186

  Fly   201 VVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWSVVIGG 265
            ||.||::|||:|.....|:.......:....:......:..|:...:.:|.|..|.|.|:.|:||
Mouse   187 VVWTDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGG 251

  Fly   266 AFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSFLGLLIFNMYKDCDPLSAG 330
            :..|.|:..|:|..|.||::....:.|:.::....||..:..:..:..|:::|..|||||||..|
Mouse   252 SLVWLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTG 316

  Fly   331 QIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQPGE 395
            :|...||.:||.|:.....:.|:||||:|..:...||:.|..:|:.:.|.::|:::       ..
Mouse   317 RIAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK-------PR 374

  Fly   396 TASAIIVKATIVIMG-ALVFGEVLLLEKV------SGILSICMSLVAIATSSTFGIFTLAVLVPW 453
            ..|....|...:..| :.::|...|....      .|:|....:::.:.:....|.|||.:|:|.
Mouse   375 MPSLAPRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPA 439

  Fly   454 ANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASC---------PGNVTARENV- 508
            .||.|...|..||..::.|:..|:.: ...|:.....||.|.|.|         ||.......:
Mouse   440 CNTPGVLSGLTAGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIP 503

  Fly   509 --WVDEEQVFPLF-----RLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLI 558
              .:|..:  |.|     .:|:.:...:|.||.::.|:|:|.:|.||...||...|:
Mouse   504 SSGMDSGR--PAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	149/547 (27%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	156/563 (28%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836520
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850