DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33124 and slc5a8

DIOPT Version :9

Sequence 1:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_021331097.1	Gene:	slc5a8 / 100329285	ZFINID:	ZDB-GENE-141211-63	Length:	609	Species:	Danio rerio

Alignment Length:	620	Identity:	188/620 - (30%)
Similarity:	306/620 - (49%)	Gaps:	88/620 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYRFGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGS 65
            |.:..|...||.||:.:..:|..||:|:.:..::    :||.||                :|:..
Zfish     3 MSSAVFSVWDYVVFIMMLAVSTGIGVYYAFAARS----QSSSAD----------------FLVAG 47

  Fly    66 GHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRS 130
            ..|...|||:||.|||:|.:.:||.|.|:|.||..:.||..|........|.|:||||..|.|.|
Zfish    48 RSLSAPPVALSLTASFMSAITVLGTPVEVYKYGAIFILICFAYAFMVALSSEIFLPVFYRLGVTS 112

  Fly   131 SYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLL 195
            :||                      :|||..|::.|||||||.:|:::....:...|||.:|..|
Zfish   113 TYE----------------------VLYTGLVIYAPALALNQVTGVDLWGAVISTGVVCTLYCTL 155

  Fly   196 GGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWS 260
            |||||||.||::||.||.|.::.|.:.:......:.........|||:...:.:|:|..|:|.||
Zfish   156 GGLKAVVWTDVFQVGIMLAGLLAVIVQSVLLQGGIPRIISDSAHGGRINLWDFDPNPLRRHTFWS 220

  Fly   261 VVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFV----LGSIIFYSVLSFLGLLIFNMY 321
            :.:||.|||||...::...|.||:|..:|..|:  :|.|:    |..:.|.:|  |.||.::::|
Zfish   221 ITVGGTFYWTSFYGINHAQVQRYISCKSLIHAK--MALFINLVTLWVVTFCAV--FCGLCLYSVY 281

  Fly   322 KDCDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGL-----SSLSVFLNSTSLVIL 381
            |:|||..|.::...|||:|..|:..:....|:||||:|..:....     |::|..:|:.:.|.:
Zfish   282 KNCDPWMAKKVSAQDQLMPYLVLDILSEFPGLPGLFVAAAYSGTFMFIVNSTVSSSVNALAAVTV 346

  Fly   382 QDIVRGCFKMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIFT 446
            .|::|....:...:.:.|  .||..:..||:..|...:...:.|:|....|:..:......|:|:
Zfish   347 TDVLRPYLSLSEKQLSWA--SKAMSLFYGAVCIGMAGIASMMGGMLQAAFSISGVIGGPLLGLFS 409

  Fly   447 LAVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQ------LHHHRLPVSVASCPGNVTAR 505
            ||:|.|.||:.|...|.::|..|:.|:..|:||.....:      |:.|...:|:|....|.||.
Zfish   410 LAILFPCANSKGGLAGLVSGLGLSLWVCIGAQIYPPPAENSRPLTLNTHGCNLSMAPDTTNWTAS 474

  Fly   506 ENVWVDEEQVF--PL-----FRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIH 563
            .:::..||:..  ||     :.||:.:...:|.:|.:.||.:||:::....:|      :.|.:
Zfish   475 MDIYRIEEETLERPLLADNWYSLSYLYFGLLGTVTAIAVGLIVSILSGGQRMK------LQPGL- 532

  Fly   564 RFLPKE---CFKQRNLDKSEAT-----DIY--TIT 588
             .|.||   |:|...:.|::.:     .||  |||
Zfish   533 -TLSKEDLTCYKAYKILKAKVSTHLLLHIYRWTIT 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	168/545 (31%)
slc5a8	XP_021331097.1	SLC5-6-like_sbd	6..527	CDD:320982	174/568 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950